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Histone modification

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Questions and Answers

What is the purpose of the H1 histone subunit in the nucleosome structure?

To bind to the linker region and stabilize the DNA wraps (correct)
To form the nucleosome core with H2A-H2B dimers and H3-H4 tetramer
To create radial loops by anchoring to the nuclear matrix
To initiate chromatin remodelling by altering the structure

What is the result of H3 and H4 lysine hyperacetylation in chromatin?

Formation of heterochromatin and inhibition of gene expression
Inhibition of chromatin remodelling and DNA packaging
Formation of euchromatin and activation of gene expression (correct)
Creation of radial loops and anchoring to the nuclear matrix

What is the function of histone deacetylases (HDAC) in chromatin?

To methylate histones and inhibit gene expression
To add acetyl groups to histones and open chromatin
To phosphorylate histones and activate gene expression
To remove acetyl groups from histones and close chromatin (correct)

What is the purpose of chromatin remodelling?

To alter the structure and accessibility of chromatin (B) Signup and view all the answers

What is the result of SAHA binding to the active site of histone deacetylases (HDAC)?

Inhibition of histone deacetylase activity (C) Signup and view all the answers

What is the role of MARs in chromatin structure?

To anchor radial loops to the nuclear matrix (A) Signup and view all the answers

What is the consequence of histone acetyltransferase activity on chromatin?

Increase chromatin accessibility (A) Signup and view all the answers

What is the function of the H3-H4 tetramer in the nucleosome structure?

To form the nucleosome core (D) Signup and view all the answers

What is the effect of histone deacetylase inhibition on chromatin?

Increase chromatin accessibility (B) Signup and view all the answers

What is the consequence of histone methylation on chromatin?

Compact chromatin into heterochromatin (A) Signup and view all the answers

Which of the following histone subunits is not part of the nucleosome core?

H1 (A) Signup and view all the answers

What is the characteristic of chromatin in the euchromatic region?

Loosely packed and accessible (D) Signup and view all the answers

Which process does not directly alter the structure of chromatin?

DNA replication (D) Signup and view all the answers

What is the role of the nuclear matrix in chromatin organization?

It creates radial loops by anchoring chromatin fibers (B) Signup and view all the answers

Which of the followinghistone modifications is likely to compact chromatin?

Deacetylation (D) Signup and view all the answers