Histone modification
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Questions and Answers

What is the purpose of the H1 histone subunit in the nucleosome structure?

  • To bind to the linker region and stabilize the DNA wraps (correct)
  • To form the nucleosome core with H2A-H2B dimers and H3-H4 tetramer
  • To create radial loops by anchoring to the nuclear matrix
  • To initiate chromatin remodelling by altering the structure
  • What is the result of H3 and H4 lysine hyperacetylation in chromatin?

  • Formation of heterochromatin and inhibition of gene expression
  • Inhibition of chromatin remodelling and DNA packaging
  • Formation of euchromatin and activation of gene expression (correct)
  • Creation of radial loops and anchoring to the nuclear matrix
  • What is the function of histone deacetylases (HDAC) in chromatin?

  • To methylate histones and inhibit gene expression
  • To add acetyl groups to histones and open chromatin
  • To phosphorylate histones and activate gene expression
  • To remove acetyl groups from histones and close chromatin (correct)
  • What is the purpose of chromatin remodelling?

    <p>To alter the structure and accessibility of chromatin</p> Signup and view all the answers

    What is the result of SAHA binding to the active site of histone deacetylases (HDAC)?

    <p>Inhibition of histone deacetylase activity</p> Signup and view all the answers

    What is the role of MARs in chromatin structure?

    <p>To anchor radial loops to the nuclear matrix</p> Signup and view all the answers

    What is the consequence of histone acetyltransferase activity on chromatin?

    <p>Increase chromatin accessibility</p> Signup and view all the answers

    What is the function of the H3-H4 tetramer in the nucleosome structure?

    <p>To form the nucleosome core</p> Signup and view all the answers

    What is the effect of histone deacetylase inhibition on chromatin?

    <p>Increase chromatin accessibility</p> Signup and view all the answers

    What is the consequence of histone methylation on chromatin?

    <p>Compact chromatin into heterochromatin</p> Signup and view all the answers

    Which of the following histone subunits is not part of the nucleosome core?

    <p>H1</p> Signup and view all the answers

    What is the characteristic of chromatin in the euchromatic region?

    <p>Loosely packed and accessible</p> Signup and view all the answers

    Which process does not directly alter the structure of chromatin?

    <p>DNA replication</p> Signup and view all the answers

    What is the role of the nuclear matrix in chromatin organization?

    <p>It creates radial loops by anchoring chromatin fibers</p> Signup and view all the answers

    Which of the followinghistone modifications is likely to compact chromatin?

    <p>Deacetylation</p> Signup and view all the answers

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