15 Questions
What is the purpose of the H1 histone subunit in the nucleosome structure?
To bind to the linker region and stabilize the DNA wraps
What is the result of H3 and H4 lysine hyperacetylation in chromatin?
Formation of euchromatin and activation of gene expression
What is the function of histone deacetylases (HDAC) in chromatin?
To remove acetyl groups from histones and close chromatin
What is the purpose of chromatin remodelling?
To alter the structure and accessibility of chromatin
What is the result of SAHA binding to the active site of histone deacetylases (HDAC)?
Inhibition of histone deacetylase activity
What is the role of MARs in chromatin structure?
To anchor radial loops to the nuclear matrix
What is the consequence of histone acetyltransferase activity on chromatin?
Increase chromatin accessibility
What is the function of the H3-H4 tetramer in the nucleosome structure?
To form the nucleosome core
What is the effect of histone deacetylase inhibition on chromatin?
Increase chromatin accessibility
What is the consequence of histone methylation on chromatin?
Compact chromatin into heterochromatin
Which of the following histone subunits is not part of the nucleosome core?
H1
What is the characteristic of chromatin in the euchromatic region?
Loosely packed and accessible
Which process does not directly alter the structure of chromatin?
DNA replication
What is the role of the nuclear matrix in chromatin organization?
It creates radial loops by anchoring chromatin fibers
Which of the followinghistone modifications is likely to compact chromatin?
Deacetylation
Test your knowledge of DNA packaging, including the structure of nucleosomes, chromatin fibers, and chromosomes. Learn about the role of histone subunits and the differences between heterochromatin and euchromatin.
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