DNA Damaging Agents and Antimetabolites

Drugs that inhibit the biosynthesis of cellular metabolites, affecting DNA/RNA synthesis.

An antimetabolite used to inhibit the conversion of cytidylic acid, affecting DNA synthesis.

A taxane that stabilizes microtubules, preventing their disassembly during cell division.

A taxane that binds free tubulin to inhibit microtubule disassembly; used for various cancers.

Cytoskeletal structures that play a crucial role in chromosome segregation during cell division.

A class of drugs such as Vinblastine that prevent microtubule polymerization.

The phase of the cell cycle where DNA is synthesized and chromosomes are duplicated.

A nucleotide precursor involved in RNA and DNA synthesis, targeted by 5-fluorouracil.

Class of cancer treatment drugs including daunorubicin and doxorubicin that interfere with DNA.

Block DNA repair enzymes in cancer cells to promote cell death, used in various cancers.

A chemotherapy drug preventing proper spindle formation, affecting mitosis in cancer cells.

Drug class like imatinib that stops signals necessary for cancer cell growth and survival.

A tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML) and ALL.

Inhibitor of epidermal growth factor receptor (EGFR) for non-small cell lung cancer treatment.

Monoclonal antibody used in breast cancer treatment by inhibiting HER2 receptor.

An anthracycline antibiotic that inserts itself into DNA to disrupt cancer cell function.

Chemicals that add alkyl groups to DNA, damaging it and preventing replication.

A process where two strands of DNA are linked together, preventing separation during replication.

A class of alkylating agents, including drugs like Cyclophosphamide and Melphalan.

A nitrosourea that alkylates the O6 of guanine, causing DNA damage and crosslinks.

A platinum drug that crosslinks DNA by attaching to N7 of guanine.

An alkylating agent that removes a mesylate group to alkylate guanine, causing crosslinks.

An alkylating agent with a similar MOA to Cyclophosphamide, affecting DNA replication.

Forms ions and cations to alkylate the O6 position on guanine, causing DNA damage.

A tyrosine kinase inhibitor that targets VEGFR to inhibit tumor growth by starving it of nutrients.

Class of drugs that inhibit PD-1, allowing T-cells to kill tumor cells by preventing tumor evasion.

A PD-1 inhibitor that enhances T-cell activity against tumors by blocking PD-1 receptor.

Blocks estrogen receptors to prevent hormone-driven cancer growth, primarily used in breast cancer.

Drugs that inhibit PD-L1, preventing tumor cells from evading the immune response mediated by PD-1.

A condition where the HER2 protein is produced in excess, leading to abnormal cell growth and proliferation in cancers.

A drug that binds to HER2 subdomain II to inhibit dimerization, preventing cancer cell signaling.

The process where two receptor proteins join together, which can activate cancer signaling pathways.

A cytotoxic agent that targets HER2 breast cancer cells, triggering apoptosis after being cleaved.

Drugs that trigger programmed cell death in cancer cells.

A drug that inhibits the 26S proteasome, leading to protein build-up and stress responses to kill cancer cells.

Drugs that block the formation of new blood vessels, starving tumors of nutrients.

A monoclonal antibody that inhibits VEGF to prevent blood vessel formation in tumors.