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Questions and Answers
Which of the following is not a common side effect of diuretics?
Which of the following is not a common side effect of diuretics?
- Hypokalemia
- Hypovolemia
- Hypertension (correct)
- Hyponatremia
Which diuretic is known to have the highest risk of causing ototoxicity?
Which diuretic is known to have the highest risk of causing ototoxicity?
- Spironolactone
- Chlorthalidone
- Hydrochlorothiazide
- Furosemide (correct)
What is the mechanism of action of thiazide diuretics?
What is the mechanism of action of thiazide diuretics?
- Inhibition of aldosterone
- Inhibition of sodium-chloride cotransporter (correct)
- Inhibition of carbonic anhydrase
- Inhibition of sodium-potassium-chloride cotransporter
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Study Notes
Diuretics and Their Side Effects
- Hypokalemia (potassium depletion) is a common side effect of diuretics.
- Hypercalcemia (elevated calcium levels) is not a common side effect of diuretics.
Diuretics and Ototoxicity
- Ethacrynic acid is a diuretic known to have the highest risk of causing ototoxicity (hearing loss or damage).
Mechanism of Action of Thiazide Diuretics
- Thiazide diuretics inhibit sodium reabsorption in the early distal tubule of the nephron, leading to increased sodium and water excretion in the urine.
- This results in decreased blood volume, cardiac output, and blood pressure.
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