21 Questions
Which of the following is a key function of drug delivery systems (DDS)?
Prolonging pharmacokinetics
What is the size range of most particle-based DDS?
80-200 nm
Which therapeutic areas have approved the use of nanoparticle-based DDS?
Oncology and infectious diseases
Which mechanism can cause complement deposits on DDS?
All of the above
What is the term used to describe the significant response caused by the release of anaphylatoxins?
Complement Activation Related PseudoAllergy (CARPA)
Which symptoms are most severe and cardiovascular in nature?
Systemic hypotension
Which of the following strategies is NOT used to reduce complement-associated side effects in drug delivery systems?
Slow infusions
Which organ takes the largest fraction of injected drug delivery systems (DDS)?
Liver
Which of the following is NOT a way in which PEGylation affects the behavior of liposomal drugs?
Reduces opsonization
Which of the following is NOT a cell involved in post-stroke inflammation?
Fibroblasts
Which class of MHC molecules is found on macrophages, dendritic cells, and B cells?
Class II
Which type of interferon is involved in stimulating the expression of class II MHC molecules on antigen presenting cells (APCs)?
IFN-𝞬
Which molecule is noncovalently attached to the polymorphic α chain of class I MHC molecules?
β2-microglobulin (β2m)
Which type of immune cells produce IFN-𝞬 during innate immune reactions to microbes or during adaptive immune reactions?
T cells
Which of the following is an advantage of using microfluidic platforms for antibody discovery?
Ability to screen millions of candidates rapidly
What is the temperature at which the entire Cytomine workflow is carried out, except for the incubation steps?
-10ºC
What assays can be performed in Cytomine to detect and isolate antibody-secreting cells?
FRET or antigen binding assays
Which domains of class I MHC molecules contain polymorphic residues?
α1 and α2 domains
Where are the polymorphic residues of class II MHC molecules located?
α1 and β1 segments
Which cellular compartments are involved in the processing of cytosolic proteins for presentation on class I MHC molecules?
Proteasomes and lysosomes
Where are the peptides derived from protein antigens degraded in APCs for presentation on class II MHC molecules?
Endosomes and lysosomes
Quiz: Understanding the Response of Distal Organs to Danger Signals Test your knowledge on how distal organs respond to danger signals in this quiz. Learn about the effects of coating nanoparticles with antibodies binding to leukocytes and how it promotes rapid uptake and elimination from lungs. Explore the steady delivery of nanoparticles to the inflamed brain and discover which cells they are found in. Challenge yourself with this informative quiz now!
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