Distal Organ Response to Danger Signals Quiz
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Questions and Answers

Which of the following is a key function of drug delivery systems (DDS)?

  • Prolonging pharmacokinetics (correct)
  • Increasing uptake into off-target tissues
  • Targeting healthy tissues
  • Decreasing drug efficacy
  • What is the size range of most particle-based DDS?

  • 50-100 nm
  • 80-200 nm (correct)
  • 200-500 nm
  • 10-50 nm
  • Which therapeutic areas have approved the use of nanoparticle-based DDS?

  • Cardiology and neurology
  • Gastroenterology and rheumatology
  • Endocrinology and dermatology
  • Oncology and infectious diseases (correct)
  • Which mechanism can cause complement deposits on DDS?

    <p>All of the above</p> Signup and view all the answers

    What is the term used to describe the significant response caused by the release of anaphylatoxins?

    <p>Complement Activation Related PseudoAllergy (CARPA)</p> Signup and view all the answers

    Which symptoms are most severe and cardiovascular in nature?

    <p>Systemic hypotension</p> Signup and view all the answers

    Which of the following strategies is NOT used to reduce complement-associated side effects in drug delivery systems?

    <p>Slow infusions</p> Signup and view all the answers

    Which organ takes the largest fraction of injected drug delivery systems (DDS)?

    <p>Liver</p> Signup and view all the answers

    Which of the following is NOT a way in which PEGylation affects the behavior of liposomal drugs?

    <p>Reduces opsonization</p> Signup and view all the answers

    Which of the following is NOT a cell involved in post-stroke inflammation?

    <p>Fibroblasts</p> Signup and view all the answers

    Which class of MHC molecules is found on macrophages, dendritic cells, and B cells?

    <p>Class II</p> Signup and view all the answers

    Which type of interferon is involved in stimulating the expression of class II MHC molecules on antigen presenting cells (APCs)?

    <p>IFN-𝞬</p> Signup and view all the answers

    Which molecule is noncovalently attached to the polymorphic α chain of class I MHC molecules?

    <p>β2-microglobulin (β2m)</p> Signup and view all the answers

    Which type of immune cells produce IFN-𝞬 during innate immune reactions to microbes or during adaptive immune reactions?

    <p>T cells</p> Signup and view all the answers

    Which of the following is an advantage of using microfluidic platforms for antibody discovery?

    <p>Ability to screen millions of candidates rapidly</p> Signup and view all the answers

    What is the temperature at which the entire Cytomine workflow is carried out, except for the incubation steps?

    <p>-10ºC</p> Signup and view all the answers

    What assays can be performed in Cytomine to detect and isolate antibody-secreting cells?

    <p>FRET or antigen binding assays</p> Signup and view all the answers

    Which domains of class I MHC molecules contain polymorphic residues?

    <p>α1 and α2 domains</p> Signup and view all the answers

    Where are the polymorphic residues of class II MHC molecules located?

    <p>α1 and β1 segments</p> Signup and view all the answers

    Which cellular compartments are involved in the processing of cytosolic proteins for presentation on class I MHC molecules?

    <p>Proteasomes and lysosomes</p> Signup and view all the answers

    Where are the peptides derived from protein antigens degraded in APCs for presentation on class II MHC molecules?

    <p>Endosomes and lysosomes</p> Signup and view all the answers

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