Distal Convoluted Tubule (DCT) in Nephron Function

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What is the primary driver of the concentration gradient in the interstitium of the thick ascending limb?

Na+Cl- reabsorption (correct)

K+ reabsorption

Urea reabsorption

H2O reabsorption

Which of the following statements is true about the counter-current multiplier mechanism?

It is a continuous process that can be envisioned as two independent processes. (correct)

It is a process that occurs only in the proximal convoluted tubule.

It is driven by the reabsorption of urea in the thick ascending limb.

It is responsible for the reabsorption of Na+ in the distal convoluted tubule.

What is the role of the basolateral Na+/K+-ATPase in the thick ascending limb?

To reabsorb K+ from the tubular fluid

To secrete Na+ into the interstitium

To maintain the low intracellular Na+ concentration (correct)

To generate the concentration gradient in the interstitium

What percentage of sodium is reabsorbed in the proximal convoluted tubule?

65% Signup and view all the answers

What is the primary function of the macula densa in the distal convoluted tubule?

To contact the afferent arteriole of the glomerulus Signup and view all the answers

What is the primary mechanism of H2O reabsorption in the thick ascending limb?

Osmosis-driven transport through the apical membrane Signup and view all the answers

What is the primary function of the thin descending limb of the loop of Henle?

Creation of a concentration gradient Signup and view all the answers

What is the role of the basolateral Na+/K+-ATPase in the thick ascending limb of the loop of Henle?

Generation of a Na+ gradient Signup and view all the answers

What is the effect of aldosterone on the abundance of ENaC channels in the distal convoluted tubule?

It increases the abundance of ENaC channels Signup and view all the answers

What is the primary site for elimination of waste and hydrogen ions in the nephron?

Proximal convoluted tubule Signup and view all the answers

What is the percentage of chloride reabsorbed in the proximal convoluted tubule?

50% Signup and view all the answers

What is the main mechanism of urea reabsorption in the proximal convoluted tubule?

Secondary active transport Signup and view all the answers

In the early distal convoluted tubule, what is the function of the luminal Na+/Cl- symporter?

Reabsorbs approximately 5% of Na+/Cl- Signup and view all the answers

What is the primary function of the basolateral Na+/K+-ATPase in principal cells?

Reabsorbs Na+ into the interstitium Signup and view all the answers

In the late distal convoluted tubule, what is the primary function of intercalated cells?

Secretes H+ ions Signup and view all the answers

What is the effect of aldosterone on the late distal convoluted tubule and collecting tubules?

Increases basolateral Na+/K+-ATPase activity Signup and view all the answers

What is the characteristic of the epithelium in the late distal convoluted tubule and collecting tubules?

Impermeable epithelium Signup and view all the answers

What is the primary function of the Ca2+ reabsorption mechanism in the early distal convoluted tubule?

Reabsorbs Ca2+ ions Signup and view all the answers

Distal Convoluted Tubule (DCT) in Nephron Function

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