Dissolution Test of Pharmaceutical Dosage Forms - In Vivo & In Vitro
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Dissolution Test of Pharmaceutical Dosage Forms - In Vivo & In Vitro

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@GalorePhotorealism

Questions and Answers

What does the Noyes-Whitney equation describe?

The rate of dissolution of spherical particles when the dissolution process is diffusion-controlled

What does the Noyes-Whitney equation include as a parameter for the rate of dissolution?

Diffusion coefficient of drug

Which apparatus is a very versatile device for the in vitro assessment of release characteristics of solid oral dosage forms?

Apparatus 3 (Reciprocating Cylinder)

What is the standard flow rate for the Flow-Through Cell apparatus?

<p>8 mL/min</p> Signup and view all the answers

In the dissolution procedure for immediate-release dosage forms, where should the specimen be withdrawn from?

<p>A zone midway between the surface of the Dissolution medium and the top of the rotating basket or blade</p> Signup and view all the answers

What is the main difference between solubility and dissolution?

<p>Solubility measures how much of the unaltered drug can be dissolved, whereas dissolution measures the rate at which the altered drug dissolves in solution.</p> Signup and view all the answers

Which factor is NOT known to affect the dissolution rate of drugs?

<p>The color of the drug</p> Signup and view all the answers

Why is slow dissolution of solid drugs associated with poor performance in vivo?

<p>Slow dissolution results in slower absorption of the drug</p> Signup and view all the answers

What does in vitro bioavailability refer to?

<p>The amount of drug that reaches the systemic circulation from the site of administration after oral dosing</p> Signup and view all the answers

What does in vivo evaluation of oral dosage forms involve?

<p>Evaluating the performance of drugs within a living organism</p> Signup and view all the answers

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