31 Questions
What is the primary affected area in lichen sclerosus et atrophicus?
Anogenital area
Which of the following is a possible pathogenesis for lichen sclerosus et atrophicus?
Autoimmunity
Which of the following is a characteristic feature of lichen sclerosus et atrophicus?
Smooth, white parchment-like areas
What are the reported correlations in terms of genetic susceptibility for lichen sclerosus et atrophicus?
High correlation between twins and family members
Which group of women primarily have lichen sclerosus et atrophicus?
Women with low estrogen state
Which condition is characterized by vulval and perianal itching, pain from skin trauma, and dysuria?
Lichen sclerosus
Which of the following is not a known infectious cause of lichen sclerosus et atrophicus?
Herpes simplex virus
Which condition is a non-specific response to recurrent scratching to relieve pruritus, characterized by white plaques and marked epidermal thickening?
Lichen simplex chronicus
Which condition is characterized by verrucous lesions on the vulva, perineum, and vagina, caused by sexually transmitted HPV types 6 or 11?
Condyloma acuminatum
Which condition is associated with dysplasia, varying degrees of atypia, and has not invaded the basement membrane but has invasive potential?
Vulval intraepithelial neoplasia
What is the main issue in lichen sclerosus?
Increased risk of vulvar cancer
What is the characteristic histological feature of lichen simplex chronicus?
Marked epidermal thickening
What is the cause of condyloma acuminatum?
Viral infection (HPV types 6 or 11)
What is a common symptom of lichen sclerosus?
Pain from skin trauma
What type of women are most commonly affected by classic (VIN)?
Pre-menopausal women
What is a distinguishing feature of vulval intraepithelial neoplasia in postmenopausal women?
Unifocal presentation
What is the uncertain pathogenesis of lichen sclerosus et atrophicus thought to involve?
Autoimmunity, such as autoantibody production against ECMP1
What is the characteristic feature of squamous vulvar intraepithelial neoplasia (VIN)?
Dysplasia, varying degrees of atypia, and invasive potential without invading the basement membrane
Which condition is a non-specific response to recurrent scratching to relieve pruritus, characterized by white plaques and marked epidermal thickening?
Squamous cell hyperplasia (lichen simplex chronicus)
What is the primary affected area in lichen sclerosus et atrophicus?
Anogenital area
What is the distinguishing feature of vulval intraepithelial neoplasia in postmenopausal women?
Thinning of the epidermis with loss of rete ridges
What is the main issue in lichen sclerosus et atrophicus?
Smooth, white parchment-like areas due to papules or macules coalescing
What is the distinguishing feature of vulval intraepithelial neoplasia in postmenopausal women?
Unifocal lesions not graded
Which condition is associated with dysplasia, varying degrees of atypia, and has not invaded the basement membrane but has invasive potential?
Vulval Intraepithelial Neoplasia
What is the characteristic histological feature of lichen simplex chronicus?
Marked epidermal thickening with significant surface hyperkeratosis
Which condition is characterized by vulval and perianal itching, pain from skin trauma, and dysuria?
Lichen sclerosus et atrophicus
What is the cause of condyloma acuminatum?
Benign Exophytic Lesions
What type of women are most commonly affected by classic (VIN)?
Premenopausal women
What are the reported correlations in terms of genetic susceptibility for lichen sclerosus et atrophicus?
Uncertain genetic correlations have been reported.
[Difficult] What is the uncertain pathogenesis of lichen sclerosus et atrophicus thought to involve?
Uncertain pathogenesis thought to involve autoimmune or genetic factors.
[Difficult] What is the main issue in lichen sclerosus et atrophicus?
Main issues are the scarring complications of the disease.
Test your knowledge of the classification of disorders of the vulva, including nonneoplastic epithelial disorders, intraepithelial neoplasia, and invasive diseases such as vulval cancer. Explore conditions like lichen sclerosus, squamous vulvar intraepithelial neoplasia, and extramammary Paget's disease.
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