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Discover the World of Actinomycins

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Questions and Answers

What is the primary effect of dactinomycin's interaction with DNA?

Inhibition of DNA helicase

Inhibition of RNA polymerase (correct)

Inhibition of DNA polymerase

Inhibition of DNA ligase

What is the primary mechanism of cytotoxicity of dactinomycin?

Binding covalently to DNA

Binding covalently to RNA

Binding noncovalently to double-stranded DNA by partial intercalation between adjacent guanine cytosine bases (correct)

Binding noncovalently to RNA

Which antineoplastic agent is a pyrrolopyrimidine analog of folate with antifolate activity?

Pemetrexed (correct)

Methotrexate

Leucovorin

Streptomyces

What is the structural feature of dactinomycin important for its mechanism of cytotoxicity?

The planar phenoxazone ring Signup and view all the answers

What is the major side effect seen with the use of methotrexate?

Pulmonary fibrosis Signup and view all the answers

What is the cell cycle specificity of dactinomycin?

G1 and S phases Signup and view all the answers

In which phases of the cell cycle is dactinomycin considered cell cycle specific?

G1 and S phases Signup and view all the answers

What is the therapeutic use of dactinomycin?

Treatment of Wilms tumor in children as well as in the treatment of choriocarcinoma and testicular carcinoma Signup and view all the answers

What is the mechanism of action of methotrexate?

Inhibition of DHFR and TS Signup and view all the answers

What is the mechanism by which antineoplastic antibiotics target DNA?

Intercalation, alkylation, and strand breakage Signup and view all the answers

What is the function of tetrahydrofolate (THF) in enzymatic processes?

One-carbon carrier for de novo synthesis of thymidylate, purine nucleotides, and amino acids Signup and view all the answers

What is the primary way in which resistance to methotrexate can occur?

All of the above Signup and view all the answers

What is the common source of many of the antineoplastic antibiotics?

Soil fungus Streptomyces Signup and view all the answers

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Description

Test your knowledge on Actinomycins with this quiz! Learn about the phenoxazone chromophore, the different species of Streptomyces that produce actinomycins, and the unique properties of actinomycin D. Challenge yourself with questions on the attached peptide portion and the amide linkage of this important compound.