5 Questions
What are the pharmacodynamic effects of digoxin?
The pharmacodynamic effects of digoxin include increased cardiac output, decreased pulmonary capillary wedge pressure, and increased ejection fraction.
What are the neurohormonal effects of digoxin?
The neurohormonal effects of digoxin include improved baroreceptor sensitivity, decreased norepinephrine concentration, decreased renin-angiotensin activations, sympathoinhibitory effect, and increase release of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP).
How does digoxin increase contractility?
Digoxin increases contractility by inhibiting the sodium-potassium exchange in the sodiumpotassium-ATPase pump leading to an increase of sodium in the myocytes. This increase results in decreased outflow of calcium from the myocyte and greater contractile force of the myocardium.
What is the bioavailability range of digoxin?
The bioavailability of digoxin can range from 70 percent to nearly 100 percent, depending on the type of oral formulation.
What is the estimated elimination half-life of digoxin?
The estimated elimination half-life of digoxin can take as long as 48 hours.
Test your knowledge about the pharmacodynamic effects of digoxin, including its impact on cardiac output, pulmonary capillary wedge pressure, and neurohormonal effects.
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