Podcast
Questions and Answers
Which of the following correctly describes the role of intrinsic nerve plexuses in the regulation of digestive function?
Which of the following correctly describes the role of intrinsic nerve plexuses in the regulation of digestive function?
Which of the following statements accurately describes the relationship between digestion and absorption in the digestive system?
Which of the following statements accurately describes the relationship between digestion and absorption in the digestive system?
The secretion of bile from the liver plays a crucial role in the digestive process. Which of the following statements accurately reflects the function of bile?
The secretion of bile from the liver plays a crucial role in the digestive process. Which of the following statements accurately reflects the function of bile?
The digestive system relies on a complex interplay of factors to regulate its function effectively. Which of the following is NOT a primary mechanism involved in regulating digestive functions?
The digestive system relies on a complex interplay of factors to regulate its function effectively. Which of the following is NOT a primary mechanism involved in regulating digestive functions?
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Which of the following statements best describes the role of motility in digestive function?
Which of the following statements best describes the role of motility in digestive function?
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Which of the following is NOT a function of HCl in the stomach?
Which of the following is NOT a function of HCl in the stomach?
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What is the main function of retropulsion in the stomach?
What is the main function of retropulsion in the stomach?
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Which of the following is NOT a cause of vomiting?
Which of the following is NOT a cause of vomiting?
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What is the role of the parietal cells in gastric acid secretion?
What is the role of the parietal cells in gastric acid secretion?
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During which phase of gastric secretion is digestion of proteins initiated?
During which phase of gastric secretion is digestion of proteins initiated?
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What is the main mechanism responsible for the movement of H+ ions into the lumen of the stomach?
What is the main mechanism responsible for the movement of H+ ions into the lumen of the stomach?
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What is the role of the luminal K+ channel in gastric acid secretion?
What is the role of the luminal K+ channel in gastric acid secretion?
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Which of the following is NOT a characteristic of receptive relaxation?
Which of the following is NOT a characteristic of receptive relaxation?
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Which of the following statements accurately describes the role of the uvula in swallowing?
Which of the following statements accurately describes the role of the uvula in swallowing?
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What is the primary function of the pyloric sphincter?
What is the primary function of the pyloric sphincter?
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Which of the following is NOT a function of saliva?
Which of the following is NOT a function of saliva?
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Which of these statements correctly describes the mechanical action of mastication?
Which of these statements correctly describes the mechanical action of mastication?
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Which of the following digestive actions is primarily associated with the stomach?
Which of the following digestive actions is primarily associated with the stomach?
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Which of the following statements accurately describes the relationship between the esophagus and the stomach?
Which of the following statements accurately describes the relationship between the esophagus and the stomach?
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Which of the following statements best describes the role of the epiglottis during swallowing?
Which of the following statements best describes the role of the epiglottis during swallowing?
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Which of the following is NOT considered to be a function of the digestive system?
Which of the following is NOT considered to be a function of the digestive system?
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Which of the following statements accurately describes the role of gastrin in the gastric phase of digestion?
Which of the following statements accurately describes the role of gastrin in the gastric phase of digestion?
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In the intestinal phase of digestion, what is the primary mechanism by which the duodenum controls the rate of gastric emptying?
In the intestinal phase of digestion, what is the primary mechanism by which the duodenum controls the rate of gastric emptying?
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Which of the following hormone(s) directly contribute to the reduction of gastric motility and secretion during the intestinal phase of digestion?
Which of the following hormone(s) directly contribute to the reduction of gastric motility and secretion during the intestinal phase of digestion?
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What is the primary trigger for the release of secretin and CCK during the intestinal phase of digestion?
What is the primary trigger for the release of secretin and CCK during the intestinal phase of digestion?
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The cephalic phase of digestion is characterized by:
The cephalic phase of digestion is characterized by:
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Which of the following is NOT a function of the liver?
Which of the following is NOT a function of the liver?
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What is the primary mechanism by which the enterogastric reflex slows down gastric emptying?
What is the primary mechanism by which the enterogastric reflex slows down gastric emptying?
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Which of the following best describes the role of bile salts in digestion?
Which of the following best describes the role of bile salts in digestion?
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Which of the following statements is FALSE regarding the absorption of vitamins?
Which of the following statements is FALSE regarding the absorption of vitamins?
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Which of the following is NOT a factor that directly contributes to the movement of water into the lumen of the duodenum?
Which of the following is NOT a factor that directly contributes to the movement of water into the lumen of the duodenum?
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What is the role of bile in lipid absorption in the small intestine?
What is the role of bile in lipid absorption in the small intestine?
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Which of the following statements accurately describes the absorption of iron in the small intestine?
Which of the following statements accurately describes the absorption of iron in the small intestine?
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What is the primary mechanism by which the small intestine maintains biochemical balance between the stomach, pancreas, and itself?
What is the primary mechanism by which the small intestine maintains biochemical balance between the stomach, pancreas, and itself?
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What is the primary function of bile salts in fat digestion?
What is the primary function of bile salts in fat digestion?
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Which of the following statements about the enterohepatic circulation is TRUE?
Which of the following statements about the enterohepatic circulation is TRUE?
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What is the role of CCK in digestion?
What is the role of CCK in digestion?
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Which of the following pancreatic enzymes is secreted in an active form?
Which of the following pancreatic enzymes is secreted in an active form?
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What is the primary function of the pancreatic bicarbonate solution?
What is the primary function of the pancreatic bicarbonate solution?
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Which of the following hormones stimulates the release of pancreatic enzymes?
Which of the following hormones stimulates the release of pancreatic enzymes?
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Which of the following is NOT a primary function of the liver?
Which of the following is NOT a primary function of the liver?
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Which of the following statements about the liver’s blood flow is TRUE?
Which of the following statements about the liver’s blood flow is TRUE?
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Which of the following is a major hormone of the duodenum?
Which of the following is a major hormone of the duodenum?
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Which of the following statements about bile is TRUE?
Which of the following statements about bile is TRUE?
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Which of the following is NOT a function of the pancreas?
Which of the following is NOT a function of the pancreas?
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Which of the following statements about pancreatic insufficiency is CORRECT?
Which of the following statements about pancreatic insufficiency is CORRECT?
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Which of the following digestive hormones is NOT primarily produced by the duodenum?
Which of the following digestive hormones is NOT primarily produced by the duodenum?
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Which of the following is the primary function of the enzyme carboxypeptidase?
Which of the following is the primary function of the enzyme carboxypeptidase?
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Flashcards
Digestive Processes
Digestive Processes
Four basic processes: motility, secretion, digestion, absorption.
Motility
Motility
Contraction of smooth muscle for mixing and moving contents in GIT.
Secretion
Secretion
Release of substances like mucus, enzymes, and hormones during digestion.
Digestion
Digestion
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Absorption
Absorption
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GI hormones
GI hormones
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Receptors in digestive tract
Receptors in digestive tract
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Oral cavity functions
Oral cavity functions
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Mastication
Mastication
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Composition of saliva
Composition of saliva
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Functions of saliva
Functions of saliva
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Pharynx and esophagus
Pharynx and esophagus
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Swallowing process
Swallowing process
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Receptive Relaxation
Receptive Relaxation
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Retropulsion
Retropulsion
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Gastric Emptying
Gastric Emptying
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Vomiting Mechanism
Vomiting Mechanism
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Hydrochloric Acid (HCl)
Hydrochloric Acid (HCl)
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Functions of HCl
Functions of HCl
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Cephalic Phase
Cephalic Phase
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Gastric Phase
Gastric Phase
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Intestinal Phase
Intestinal Phase
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Gastrin
Gastrin
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CCK (Cholecystokinin)
CCK (Cholecystokinin)
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Enterogastric Reflex
Enterogastric Reflex
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Functions of the Liver
Functions of the Liver
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Sodium channels
Sodium channels
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Na+ - Cl- symporter
Na+ - Cl- symporter
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Passive absorption of water
Passive absorption of water
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Vitamin B12 absorption
Vitamin B12 absorption
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Iron absorption
Iron absorption
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Calcium absorption mechanism
Calcium absorption mechanism
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Impact of diarrhea
Impact of diarrhea
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Role of small intestine
Role of small intestine
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Liver Blood Flow
Liver Blood Flow
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Hepatic Portal Vein
Hepatic Portal Vein
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Bile
Bile
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Gallbladder
Gallbladder
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Bile Salts
Bile Salts
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Enterohepatic Circulation
Enterohepatic Circulation
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Fat Emulsion
Fat Emulsion
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Micelles
Micelles
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Excretion of Bilirubin
Excretion of Bilirubin
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Pancreas
Pancreas
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Pancreatic Amylase
Pancreatic Amylase
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Pancreatic Lipase
Pancreatic Lipase
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Proteolytic Enzymes
Proteolytic Enzymes
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Study Notes
HSC1008 Anatomy and Physiology 2
- Course name: HSC1008 Anatomy and Physiology 2
- Course topic: Digestive System
- Lecturer: Andy Lee (PhD), Assistant Professor
- Contact details: Faculty Hall #04-17, 6592 2524, [email protected]
Digestive System 1
- Learning Outcomes:
- Describe the 4 basic digestive processes
- Discuss the main functions of the oral cavity and the mechanisms involved
- Discuss the main functions of the stomach, liver and pancreas
- Explain the control of gastric secretion and motility
- Discuss the mechanism and control of bile and pancreatic secretions
- Describe the role of the main GI hormones in regulation of digestive function
Revision (Anatomy)
- Diagram including: Nasal passages, mouth, salivary glands, pharynx, pharyngoesophageal sphincter, trachea, esophagus, gastroesophageal sphincter, liver, stomach, gallbladder, gallbladder, pancreas, duodenum, descending colon, transverse colon, ascending colon, jejunum, cecum, ileum, appendix, sigmoid colon, rectum, and anus.
A Journey Through the Digestive System
- Learning video link: https://youtu.be/_QYwscALNng
4 Basic Digestive Processes
- Motility:
- Contraction of smooth muscle in the digestive tract
- Mixing and moving the contents in the GIT
- Secretion:
- Exocrine and endocrine secretions
- Mucus along entire digestive tract
- Saliva, acid, enzymes, bile, bicarbonate, hormones, etc
- Digestion:
- Food molecules are generally large
- Cannot cross the plasma membrane of intestinal epithelial cells
- Chemically break down complex macromolecules into smaller absorbable molecules.
- Absorption:
- Digested material transferred from GIT lumen to blood or lymph
Oral Cavity and Esophagus
- Swallowing - All-or-none reflex
- Oropharyngeal stage
- Tongue pushes bolus of food to the pharynx
- Note functions of uvula, tongue, glottis, and epiglottis
- Esophageal stage
- Peristaltic wave from beginning to end of esophagus
- Forcing bolus toward the stomach
- Oropharyngeal stage
Swallowing
- Video on Swallowing:
Stomach
- J-shaped chamber
- Stores food
- Begins protein digestion
- Mixing movements produce chyme
Gastric Storage, Mixing and Emptying
- Storage:
- Body of stomach
- Receptive relaxation - expansion with little change in intragastric pressure
- Mixing:
- Mainly in the pyloric antrum
- Peristaltic contractions are stronger and more vigorous
- Retropulsion - churning action breaks food into smaller pieces forming chyme.
- Emptying:
- Controlled propulsion of chyme into the duodenum with each peristaltic wave
Gastric Emptying and Mixing
- Diagram showing peristaltic contraction, gastric emptying, and mixing with labels for esophagus, stomach, gastroesophageal sphincter, pyloric sphincter, duodenum
Digestion in Stomach
- Labels for esophagus, gastroesophageal sphincter, pyloric sphincter, duodenum, and smooth muscle
Gastric Motility and Emptying
- Factors regulating gastric motility and emptying:
- Within the stomach
- Volume of chyme - distension affects gastric smooth muscle excitability
- Degree of fluidity - contents need to be fluid
- Within the duodenum
- Presence of fat, acid, hypertonicity, or distension - triggers enterogastric reflex
- Outside the digestive system
- Emotion - alters autonomic balance
- Intense pain - increases sympathetic activity
- Within the stomach
- Table includes effects on gastric motility and emptying
Vomiting
- Not a function of retroperistalsis in the stomach
- Contraction of respiratory muscles and abdominal muscles
- Stomach, esophagus, and sphincters relaxed.
- Controlled by vomiting center (area postrema - medulla of brainstem)
- Causes: Throat stimulation, irritation of stomach, elevated intracranial pressure, etc.
Gastric Secretion
- Diagram including surface epithelial cells, gastric pits, gastric glands, pyloric atrium, mucous cells, chief cells, parietal cells, enteroendocrine/paracrine cells, ECL cells, G cells, D cells
Gastric Acid Secretion
- Hydrochloric acid secreted by parietal cells and activates pepsinogen
- Mechanism of H+ and Cl- secretion:
- CO2 + H2O → HCO3− + H+
- H+-K+ ATPase pump
- Luminal K+ channel allows K+ to passively leak back
- Cl− - HCO3− antiporter
- Cl− channel
Functions of HCl
- Formation of pepsin
- Breakdown of connective tissue and muscle fibers
- Denaturation of protein
- Killing of microorganisms
Control of Gastric Secretion
- Cephalic Phase: prepares stomach for arrival of food
- Gastric Phase: increased secretion started in the previous phase, initiates digestion of proteins
- Intestinal Phase: controls rate of gastric emptying
Cephalic Phase
- Preparing stomach for arrival of food
- Short phase (minutes)
- Directed by CNS via vagus nerve and submucosal plexus
- Increased production of gastric juice and release of gastrin
Gastric Phase
- Increased secretion of gastric juice
- Long phase (3-4 hours)
- Stimulation of stretch and chemoreceptors
- Effects of gastrin (release of histamine and its local effect)
- Sustained increased production of gastric juice and increased motility (mixing)
Intestinal Phase
- Control of rate of gastric emptying
- Long duration
- Distension of duodenum triggers enterogastric reflex
- Stimulation of CCK, GIP, and secretin release (hormone release)
- Feedback inhibition of pepsinogen and HCl production and gastric motility
General Effect of Some GI Hormones on Gastric Function
- Gastrin: ↑ HCl, pepsinogen, gastric motility
- Secretin, GIP, and CCK: ↓ gastric motility and secretion
Intestinal Phase
- Distension of duodenum triggers enterogastric reflex - ↓ gastric contraction
- Arrival of chyme in duodenum (lipids, carbohydrates, low pH) trigger release of hormones (secretin, CCK, etc.) - ↓gastric contraction, ↓gastric secretions
Functions of the Liver
- Secretion of bile salts
- Metabolic processing of nutrients
- Detoxifying/degrading
- Synthesizing plasma proteins
- Storing glycogen, fats, vitamins, etc.
- Activating vitamin D
- Hormone secretion
- Excretion of cholesterol and bilirubin
- Removing bacteria and worn-out RBCs
Liver Blood Flow
- The liver receives blood from two sources:
- Arterial blood (O2 supply and blood-borne metabolites) delivered by the hepatic artery.
- Venous blood (draining the digestive tract) carried by the hepatic portal vein for processing and storage of newly absorbed nutrients
- Blood leaves the liver via the hepatic vein.
Bile
- Continuously secreted by the liver into the duodenum and diverted to the gallbladder between meals
- Contains bile salts, cholesterol, lecithin, bilirubin, etc. (without digestive enzymes)
- Bile concentrated in the gallbladder
Enterohepatic Circulation
- Bile salts are recycled through the enterohepatic circulation.
- Bile salts are derivatives of cholesterol
- Enterohepatic circulation: recycling of bile salts between the small intestine and liver.
Functions of Bile
- Aid fat digestion and absorption
- Detergent action of bile salts converting large fat globules into small fat droplets
- Formation of micelles
- Bile salts and lecithin aggregate in small clusters.
- Fat-soluble parts huddle together in the middle to form a hydrophobic core.
Functions of Bile
- Excretion of water-insoluble substances (e.g., cholesterol and bilirubin) - bilirubin has no role in digestion
- Bile salts stimulate bile secretion
- CCK promotes gallbladder emptying (contraction of gallbladder) and relaxation of the sphincter of Oddi/hepatopancreatic sphincter (HPS)
- Hepatitis and cirrhosis are common liver disorders
Pancreas
- The pancreas is a mixture of exocrine and endocrine tissue
- An elongated gland behind and below the stomach
- Exocrine function
- Pancreatic enzymes by the acinar cells (e.g., pancreatic amylase, lipase, pancreatic proteolytic enzymes)
- Aqueous alkaline solution (e.g., bicarbonate)
Pancreatic Enzymes
- Pancreatic Amylase (active form, breaks down starch and glycogen)
- Pancreatic Lipase (fat digestion, triglycerides into monoglycerides and free fatty acids)
- Pancreatic Proteolytic Enzymes (Proteases, inactive form - trypsinogen, chymotrypsinogen, and procarboxypeptidase, activated by enteropeptidase, trypsin activates other enzymes and is also autocatalytic)
Pancreas
- Aqueous alkaline solution
- Pancreatic enzymes are optimal in neutral or slightly alkaline environments
- Neutralizes acidic chyme
- High concentration of bicarbonate (HCO3−)
- Pancreatic insufficiency: deficient pancreatic enzymes, impairing dietary fat digestion
Hormonal Control of Pancreatic Secretion
- Secretion of aqueous NaHCO3 solution into duodenal lumen
- Hormonal control of pancreatic digestive enzyme secretion
Overview of the GI Hormones
- Gastrin: Stimulated by protein in stomach, ↑ secretion of HCl and pepsinogen, enhances gastric motility
- Secretin: Stimulated by acid in duodenum, inhibits gastric emptying and gastric secretion, stimulates pancreas to produce HCO3
- CCK: Stimulated by chyme in duodenum; inhibits gastric motility and secretion; stimulates pancreatic enzyme secretion; stimulates contraction of gallbladder and relaxation of hepatopancreatic sphincter
- GIP: Promotes metabolic processing of nutrients once they are absorbed
Major Hormones of the Duodenum
- Gastrin (secreted by G cells, ↑ stomach motility, ↑ acid/enzyme production)
- Secretin (↑ bile secretion, ↑ pancreatic buffer secretion, ↓ gastric motility)
- GIP (↑ insulin secretion, ↓ gastric emptying,↑ glucose usage by skeletal muscles)
- Cholecystokinin (CCK) (↑ pancreatic enzyme secretion, relaxation of sphincter of Oddi, contraction of gallbladder)
- VIP (stimulates intestinal glands; dilates regional capillaries; inhibits acid production)
- Enterocrinin (stimulates mucin production by submucosal glands)
Function of Major Digestive Tract Hormones
- Diagram showing hormones their actions, and digestive tract sections (eg. Stomach, Pancreas, Small intestine)
Small Intestine
- 3 parts: duodenum, jejunum, and ileum
- Site of most digestion and absorption
- Approximately 5-6 meters long
- Motility
- Peristalsis: waves of muscular contractions that move the bolus through the digestive tract.
- Segmentation contractions: mixing and slow propulsion of the chyme
- Myenteric plexus - essential for these movements.
Peristalsis
- Waves of muscular contractions
- Moves bolus along digestive tract, oral-to-anal direction
- Myenteric plexus is essential
Segmentation Contraction
- Mixes and slowly propels chyme
- Oscillating, ring-like contractions every few centimeters
- Functions: mixing chyme with digestive juices, exposing chyme to all absorptive surfaces
Myenteric Plexus
- Located between longitudinal and circular muscle layers
- Controls mainly gastrointestinal movements, stimulated by receptors in digestive tract
Small Intestine - Motility
- Migrating motility complex (MMC): sweeps intestine clean between meals.
- Ileocecal juncture
- Prevents contamination of the small intestine by colonic bacteria.
- Ileocecal valve and sphincter.
Small Intestine - Secretion
- Pancreatic enzymes perform most digestive activities.
- Enzymes secreted by enterocytes (localized at the brush border)
- Enteropeptidase
- Disaccharidases (maltase, lactase, sucrose-isomaltase, lactase)
- Aminopeptidases
Carbohydrates
- Monosaccharides: fructose, glucose, galactose
- Disaccharides: sucrose, maltose, lactose
- Polysaccharides: starch, glycogen, etc
Proteins
- Amino acids
- Peptides
- Polypeptides
- Protein (chains of >50 amino acids).
Summary for 3 Major Classes of Nutrients
- Table summarizing digestive processes for carbohydrates, proteins, and fats
Adaptation for Absorption
- Diagram showing circular folds, villi, and microvilli in the small intestine, increasing surface area for absorption.
Mechanisms of Absorption
-
Diffusion (simple and facilitated)
- Monoglycerides and fatty acids etc
- Fructose, amino acids, etc
-
Active Transport (primary and secondary)
- Sodium
- Glucose, amino acids, and peptides, etc
Digestion and Absorption in Small Intestine
- Digestion: description of digestion and movement of ingredients through to intestines
Carbohydrate Digestion and Absorption
- Mainly starch and glycogen
- Enzymes: salivary amylase, pancreatic amylase, and disaccharidases convert carbohydrates (starch/glycogen) to monosaccharides like glucose, fructose, and galactose
- Cellulose is plant cell wall, not digestible by humans
- Major end-product is glucose.
Carbohydrate Digestion
- Dietary carbohydrates are broken down into monosaccharides, and these are absorbed by the epithelial cells of the small intestine
Carbohydrate Absorption
- Monosaccharides (glucose, galactose,or fructose) absorbed into the epithelial cells by active transport (Na+) using a symporter (SGLT).
- Fructose absorption is via facilitated diffusion (GLUT5)
- Passive facilitated diffusion through GLUT2 into the blood
Protein Digestion and Absorption
- Digestion begins in the stomach (pepsinogen ---> pepsin --> protein ---> polypeptides)
- Continues in the small intestine (trypsin, chymotrypsin - to peptides ---> amino acids, aminopeptidases)
Protein Absorption
- Amino acids absorbed via Na+/amino acid symporters
- Small peptides absorbed via H+/peptide secondary active transport
Fat Digestion
- Dietary fats (triglycerides) emulsified by bile salts into small droplets.
- Pancreatic lipase hydrolyzes triglycerides into monoglycerides and free fatty acids
- Monoglycerides and free fatty acids are absorbed into water-soluble micelles via passive diffusion
- Bile salts
- forming water-soluble micelle
Fat Absorption
- Digested fat (monoglycerides, free fatty acids) passively enter the lymph via micelles, chylomicrons form in epithelial cells and then aggregate and are coated with lipoproteins.
- Chylomicrons then extruded from cells via exocytosis and enter the lymph system.
Absorption of Sodium Chloride
- Na+-K+ ATPase creates electrochemical gradient
- Co-transport carriers (Na+-Cl− symporter, Na+-H+ antiporter, Na+-glucose symporter, Na+-amino acid symporter)
Absorption of Water
- Active reabsorption of electrolytes and nutrients creates osmotic gradients.
- Na+ - K+ ATPase creates localized concentrated area of high osmotic pressure.
- Water flows into the lumen due to hyperosmotic chyme in the duodenum.
- Water is absorbed in the jejunum and ileum.
Absorption of Vitamins
- Water-soluble vitamins (e.g., vitamin B complex, vitamin C) - mostly by carrier-mediated mechanisms
- Fat-soluble vitamins (e.g., vitamin A, D, E, K) - carried in micelles and absorbed with other lipids
- Vitamin B12 - absorbed by receptor-mediated endocytosis. Requires a complex binding with gastric intrinsic factor
Absorption of Iron and Calcium
- Iron absorption regulated, needed for hemoglobin production.
- Heme iron > Fe2+ (ferrous) > Fe3+ (ferric iron)
- Vitamin C ↑iron absorption by reducing Fe3+ to Fe2+.
- Calcium absorption - activation of vitamin D in kidney or liver is required for effective calcium absorption.
- 2/3 of daily calcium intake is absorbed
Small Intestine - Maintaining Biochemical Balance
- Biochemical balance among stomach, pancreas, and small intestine is maintained.
- Body normally does not experience a net gain or loss of acid or base during digestion
- Diarrhea results in fluid and electrolyte loss from highly fluid fecal matter.
- Excessive small intestinal motility
- Excess osmotically active particles in the lumen
- Toxins
- Dehydration, loss of nutrients, and metabolic acidosis, etc
Large Intestine
- The large intestine is primarily a drying and storage organ.
- Forms and stores feces
- Motility
- Slow and non-propulsive.
- Contractions of haustra slowly shuffle colonic contents back and forth and are initiated by rhythmic smooth muscle contractions.
- Mass movements propel feces long distances into the distal part
- Large segments of the ascending and transverse colon that contract simultaneously.
Defecation Reflex
- Feces are eliminated by the defecation reflex.
- Initiated by distension of the rectum
- Stimulates stretch receptors in the rectal wall
- Muscle contraction with relaxation of both the internal and external anal sphincter muscle.
- Voluntary straining movements increase intra-abdominal pressure,
- Contraction of abdominal muscles, and
- Forcible expiration against closed glottis (reflex)
Defecation Reflex
- 2 positive feedback loops
- Short intrinsic myenteric defecation reflex.
- Stretch receptors stimulate the plexus to increase local peristaltic contractions in the sigmoid colon and rectum.
- Short intrinsic myenteric defecation reflex.
- Parasympathetic defecation reflex.
- Stimulate mass movements in descending and sigmoid colon.
Constipation
- When feces become too dry
- Abdominal discomfort, dull headache, loss of appetite, etc
- Causes:
- Ignoring urge to defecate
- Decreased colonic motility
- Obstruction
- Impairment of defecation reflex
Gases and Secretions
- Intestinal gases are absorbed or expelled (flatus)
- Bacterial fermentation produces gases
- Large-intestine secretion is entirely protective (mucus solution)
- Colon contains myriad beneficial bacteria (microbiota and microbiome)
Absorption of Water and Salt
- The large intestine absorbs salt and water
- Converting luminal contents to feces
- Some absorption takes place within the colon but not to the same extent as in the small intestine
- Na+ actively absorbed
- Cl− follows down electrical gradient
- Water follows osmotically
References
- Chapter 16, Sherwood, L. (2016) Human Physiology: From Cells to Systems. 9th edition. Cengage
- Chapter 24, Martini, F. H., Nath, J.L., & Bartholomew, E. F. (2018). Fundamentals of Anatomy and Physiology. 11th Global Edition. Pearson.
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Description
Test your knowledge on the intricate roles of various components in the digestive system. This quiz covers intrinsic nerve plexuses, bile secretion, gastric motility, and many other key functions that regulate digestion and absorption. Challenge yourself to identify accurate statements about digestive processes and mechanisms.