Podcast
Questions and Answers
What must be addressed for a metabolite/degradate to be considered significant in dietary risk?
What must be addressed for a metabolite/degradate to be considered significant in dietary risk?
Which factor is NOT considered when assessing metabolites/degradates for dietary risk?
Which factor is NOT considered when assessing metabolites/degradates for dietary risk?
When is it appropriate to exclude the parent compound from residue definition?
When is it appropriate to exclude the parent compound from residue definition?
Which type of compounds are referenced collectively as 'metabolite/degradate'?
Which type of compounds are referenced collectively as 'metabolite/degradate'?
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What are metabolites/degradates with higher potential exposures and toxicities likely to be?
What are metabolites/degradates with higher potential exposures and toxicities likely to be?
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Which practice is generally used for determining the residues of pesticides in dietary assessments?
Which practice is generally used for determining the residues of pesticides in dietary assessments?
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In dietary risk assessments, why might a substance contribute to dietary risk?
In dietary risk assessments, why might a substance contribute to dietary risk?
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Study Notes
Residue and Dietary Risk Assessment
- Residues, including metabolites, degradates, and transformation products, are crucial for evaluating dietary risk from pesticides.
- Metabolite/degradate must significantly contribute to dietary risk to be included in exposure assessments.
- Two key factors to establish significance of metabolites/degradates are:
- The potential for human dietary exposure to the metabolite/degradate.
- The relative toxicity of the metabolite/degradate compared to its parent compound.
- Metabolites/degradates with higher exposure potential and toxicity are prioritized in dietary assessments.
Parent Compound Consideration
- The parent compound is typically included in dietary risk assessments.
- If no residues of the parent compound are found under Good Agricultural Practices (GAP), while metabolites/degradates are present at quantifiable levels, the parent compound may be excluded from the risk assessment definition.
- This exclusion can occur during supervised field trials if the parent does not appear detectable despite expected pesticide use.
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Description
This quiz focuses on the definitions and assessment of metabolites and degradates in the context of dietary risk evaluation. It addresses the critical factors determining their relevance, including potential exposure and relative toxicity. Test your understanding of these important concepts in food safety and public health.
