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DIC: Acute vs Chronic

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Questions and Answers

What is the primary difference between acute and chronic DIC?

Acute DIC develops when blood is exposed to small amounts of TF, while chronic DIC develops when blood is suddenly exposed to procoagulants.

Acute DIC occurs at all ages and races, while chronic DIC occurs more frequently in older adults.

Acute DIC occurs in patients with solid tumors, while chronic DIC occurs in patients with sepsis.

Acute DIC is characterized by hemorrhage, while chronic DIC is characterized by thrombosis. (correct)

Which group of patients is more likely to develop chronic DIC?

Patients with sepsis

Patients with large aortic aneurysms

Patients with solid tumors (correct)

Patients with venous thromboembolism

In which percentage of patients with sepsis does DIC occur?

40-60%

30-50% (correct)

15-30%

20-40%

What are the typical physical findings in patients with acute DIC?

Petechiae on the soft palate and extremities, ecchymosis at venipuncture sites Signup and view all the answers

What is the estimated occurrence of DIC in all hospitalized patients?

1% Signup and view all the answers

Which of the following is NOT a feature of managing DIC?

Administer heparin immediately Signup and view all the answers

What is the primary focus of treatment for DIC?

Addressing the underlying disorder Signup and view all the answers

What causes the clinical manifestations in patients with TTP?

Unusually large multimers of von Willebrand factor (vWF) Signup and view all the answers

What characterizes thrombotic thrombocytopenic purpura (TTP) as a hematological emergency?

Clotting in small blood vessels, low platelet count, and end organ damage Signup and view all the answers

What is responsible for the breakdown of ultralarge vWF multimers in acquired TTP?

An antibody inhibitor Signup and view all the answers