Diagnostic Haematology and Blood Transfusion Self Test 01

Questions and Answers

Which of the following antibodies are typically found in the serum of a Bombay phenotype individual?

Incomplete anti-D antibodies

Antibody A and antibody B

Antibody B and antibody O

Antibody A, antibody B, and antibody H (correct)

What is the characteristic of sickle cell anemia in terms of the β-globin chain of haemoglobin?

Valine replaces glycine in the sixth position (correct)

Glutamic acid replaces methionine in the sixth position

Glycine replaces valine in the sixth position

Valine replaces glutamic acid in the sixth position of α-globin chain

Which technique is used in the laboratory for the conclusive diagnosis of leukemia?

Computed tomography

Bone marrow aspirations (correct)

Venous blood sampling

Peripheral blood smears

Which of the following haematological disorders is characterized by bite and blister cells in the peripheral thin blood smear?

G6PD Deficiency Signup and view all the answers

Which of the following parameters is typically RAISED in an individual with Iron Deficiency Anaemia?

Total Iron Binding Capacity Signup and view all the answers

What is the major component of the acquired immune system?

Lymphocytes Signup and view all the answers

Which of the following can cause a FALSE NEGATIVE result in ABO Blood Grouping?

Cold Agglutinin Signup and view all the answers

Which of the following is NOT a characteristic of sickle cell anemia?

Glycine replaces valine in the sixth position of β-globin chain Signup and view all the answers

What are the major components of haemostasis?

Platelets, coagulation, fibrinolytic and aggregation Signup and view all the answers

Which of the following components are involved in the Fibrinolytic system?

Plasminogen, plasminogen activator, plasmin and plasminogen activator inhibitors Signup and view all the answers

Which of the following mediators are involved in vasoconstriction in primary haemostasis?

Compounds such as ADP and thromboxanes Signup and view all the answers

Which of the following is a compatibility test used to detect in vivo sensitization of Red blood cells?

Direct Antiglobulin test Signup and view all the answers

Which of the following leads to the occurrence of Haemolytic Disease of a Newborn due to ABO incompatibility?

Mother is blood group O and newborn group A or B Signup and view all the answers

What is the primary function of platelets in primary haemostasis?

To form a platelet plug Signup and view all the answers

Which of the following is a key component of the coagulation cascade?

Fibrin Signup and view all the answers

Which of the following is involved in the regulation of platelet aggregation?

Thromboxanes Signup and view all the answers

Which of the following viral diseases cause high titers of cold antibodies?

Infectious mononucleosis Signup and view all the answers

What is assessed by the Bleeding time test?

Coagulation, endothelial and platelet function Signup and view all the answers

Which disorder is associated with platelets not able to adhere to the subendothelial collagen when a blood vessel is injured?

Von Willebrand Disease Signup and view all the answers

What is the primary mechanism of platelet activation in primary haemostasis?

Binding to subendothelial collagen Signup and view all the answers

Which of the following coagulation factors is not involved in the Intrinsic Pathway?

VII Signup and view all the answers

What is the primary role of platelets in primary haemostasis?

To form a platelet plug Signup and view all the answers

Which of the following is a consequence of defective platelet function?

Prolonged bleeding time Signup and view all the answers

What is the term for the initial plug formed by platelets in response to vascular injury?

Hemostatic plug Signup and view all the answers

Study Notes

Viral Diseases and Hematology

Certain viral diseases cause high titers of cold antibodies, including Infectious Mononucleosis.
Mumps, Measles, Hepatitis, and Acquired Immunodeficiency Virus are not typically associated with high titers of cold antibodies.

Bleeding Time Test

The Bleeding Time Test assesses Coagulation, endothelial, and platelet function.
It does not solely assess Coagulation function or platelet number.

Platelet Disorders

Von Willebrand Disease is a disorder associated with platelets not adhering to subendothelial collagen when a blood vessel is injured.
Leukemia, Thrombocytosis, Thrombocytopenia, and Venous Thromboembolism diseases are not characterized by this specific platelet dysfunction.

Red Blood Cell Disorders

Glucose-6-phosphate dehydrogenase deficiency is a condition characterized by hemolysis of red blood cells following exposure to oxidative stress.

ABO Grouping

Using infected serum in ABO grouping can result in false negative reactions.
It is not a guarantee of false positive reactions.

Coagulation Factors

Factors XII, XI, IX, and X are involved in the Intrinsic Pathway of coagulation.
Valine replaces glutamic acid in the sixth position of β-globin chain of hemoglobin in sickle cell disease.

Bombay Phenotype

Antibodies A, B, and H are found in the serum of individuals with the Bombay phenotype.

Leukemia Diagnosis

Bone marrow aspirations are used in the laboratory for conclusive diagnosis of Leukemia.
Peripheral blood smears, computed tomography, and venous blood are not conclusive diagnostic tools for Leukemia.

Hematological Disorders

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hematological disorder characterized by bite and blister cells in the peripheral thin blood smear.
Aplastic anaemia, Pernicious anaemia, Chronic blood loss, and Iron deficiency anaemia are not characterized by this specific type of blood smear.

Iron Deficiency Anaemia

Total Iron Binding Capacity is raised in an individual with Iron Deficiency Anaemia.
MCV, MCH, Serum Iron, and Serum ferritin are not typically raised in this condition.

Acquired Immune System

Lymphocytes are the major component of the acquired immune system.
Skin, Lysozyme, Macrophages, and Normal flora bacteria are not the primary components of the acquired immune system.

ABO Blood Grouping

Cold Agglutinin, Infected red cells, and Rouleaux formation can cause false negative results in ABO Blood Grouping.
Infected serum can cause false negative reactions, but it is not a guarantee of false negative results.

Fibrinolytic System

Plasminogen, plasminogen activator, and plasmin are involved in the Fibrinolytic system.
Platelets, Adenosine Diphosphate, and platelet inhibitor are not directly involved in this system.

Vasoconstriction

Thromboxanes and serotonin are mediators of vasoconstriction in primary haemostasis.
Platelets aggregation, ADP, and thrombokinase are not primary mediators of vasoconstriction.

Haemostasis

Vascular system, platelets, coagulation, and fibrinolytic are the major components of haemostasis.
White blood cells and serotonin are not primary components of haemostasis.

Haemolytic Disease of a Newborn

ABO incompatibility can occur when the mother is blood group O and the newborn is group A or B.
This is not the only possible scenario, but it is a common one.

Compatibility Test

The Direct Antiglobulin test is used to detect in vivo sensitization of Red blood cells.
Fragility test, Haemolysin test, Capillary resistance test, and Indirect antiglobulin test are not used for this purpose.

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Description

Test your knowledge of diagnostic haematology and blood transfusion with this self-assessment quiz, covering topics such as viral diseases and blood-related conditions.