Questions and Answers
Which of the following antibodies are typically found in the serum of a Bombay phenotype individual?
What is the characteristic of sickle cell anemia in terms of the β-globin chain of haemoglobin?
Which technique is used in the laboratory for the conclusive diagnosis of leukemia?
Which of the following haematological disorders is characterized by bite and blister cells in the peripheral thin blood smear?
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Which of the following parameters is typically RAISED in an individual with Iron Deficiency Anaemia?
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What is the major component of the acquired immune system?
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Which of the following can cause a FALSE NEGATIVE result in ABO Blood Grouping?
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Which of the following is NOT a characteristic of sickle cell anemia?
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What are the major components of haemostasis?
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Which of the following components are involved in the Fibrinolytic system?
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Which of the following mediators are involved in vasoconstriction in primary haemostasis?
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Which of the following is a compatibility test used to detect in vivo sensitization of Red blood cells?
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Which of the following leads to the occurrence of Haemolytic Disease of a Newborn due to ABO incompatibility?
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What is the primary function of platelets in primary haemostasis?
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Which of the following is a key component of the coagulation cascade?
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Which of the following is involved in the regulation of platelet aggregation?
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Which of the following viral diseases cause high titers of cold antibodies?
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What is assessed by the Bleeding time test?
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Which disorder is associated with platelets not able to adhere to the subendothelial collagen when a blood vessel is injured?
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What is the primary mechanism of platelet activation in primary haemostasis?
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Which of the following coagulation factors is not involved in the Intrinsic Pathway?
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What is the primary role of platelets in primary haemostasis?
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Which of the following is a consequence of defective platelet function?
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What is the term for the initial plug formed by platelets in response to vascular injury?
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Study Notes
Viral Diseases and Hematology
- Certain viral diseases cause high titers of cold antibodies, including Infectious Mononucleosis.
- Mumps, Measles, Hepatitis, and Acquired Immunodeficiency Virus are not typically associated with high titers of cold antibodies.
Bleeding Time Test
- The Bleeding Time Test assesses Coagulation, endothelial, and platelet function.
- It does not solely assess Coagulation function or platelet number.
Platelet Disorders
- Von Willebrand Disease is a disorder associated with platelets not adhering to subendothelial collagen when a blood vessel is injured.
- Leukemia, Thrombocytosis, Thrombocytopenia, and Venous Thromboembolism diseases are not characterized by this specific platelet dysfunction.
Red Blood Cell Disorders
- Glucose-6-phosphate dehydrogenase deficiency is a condition characterized by hemolysis of red blood cells following exposure to oxidative stress.
ABO Grouping
- Using infected serum in ABO grouping can result in false negative reactions.
- It is not a guarantee of false positive reactions.
Coagulation Factors
- Factors XII, XI, IX, and X are involved in the Intrinsic Pathway of coagulation.
- Valine replaces glutamic acid in the sixth position of β-globin chain of hemoglobin in sickle cell disease.
Bombay Phenotype
- Antibodies A, B, and H are found in the serum of individuals with the Bombay phenotype.
Leukemia Diagnosis
- Bone marrow aspirations are used in the laboratory for conclusive diagnosis of Leukemia.
- Peripheral blood smears, computed tomography, and venous blood are not conclusive diagnostic tools for Leukemia.
Hematological Disorders
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a hematological disorder characterized by bite and blister cells in the peripheral thin blood smear.
- Aplastic anaemia, Pernicious anaemia, Chronic blood loss, and Iron deficiency anaemia are not characterized by this specific type of blood smear.
Iron Deficiency Anaemia
- Total Iron Binding Capacity is raised in an individual with Iron Deficiency Anaemia.
- MCV, MCH, Serum Iron, and Serum ferritin are not typically raised in this condition.
Acquired Immune System
- Lymphocytes are the major component of the acquired immune system.
- Skin, Lysozyme, Macrophages, and Normal flora bacteria are not the primary components of the acquired immune system.
ABO Blood Grouping
- Cold Agglutinin, Infected red cells, and Rouleaux formation can cause false negative results in ABO Blood Grouping.
- Infected serum can cause false negative reactions, but it is not a guarantee of false negative results.
Fibrinolytic System
- Plasminogen, plasminogen activator, and plasmin are involved in the Fibrinolytic system.
- Platelets, Adenosine Diphosphate, and platelet inhibitor are not directly involved in this system.
Vasoconstriction
- Thromboxanes and serotonin are mediators of vasoconstriction in primary haemostasis.
- Platelets aggregation, ADP, and thrombokinase are not primary mediators of vasoconstriction.
Haemostasis
- Vascular system, platelets, coagulation, and fibrinolytic are the major components of haemostasis.
- White blood cells and serotonin are not primary components of haemostasis.
Haemolytic Disease of a Newborn
- ABO incompatibility can occur when the mother is blood group O and the newborn is group A or B.
- This is not the only possible scenario, but it is a common one.
Compatibility Test
- The Direct Antiglobulin test is used to detect in vivo sensitization of Red blood cells.
- Fragility test, Haemolysin test, Capillary resistance test, and Indirect antiglobulin test are not used for this purpose.
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Description
Test your knowledge of diagnostic haematology and blood transfusion with this self-assessment quiz, covering topics such as viral diseases and blood-related conditions.