10 Questions
What is the name of the gene that has a mutation at position 27?
H3
What is the name of the amino acid at position 34 in the H3 gene?
Glycine
What is the name of the protein that is associated with the V600E mutation?
BRAF
What is the name of the fusion gene that is a result of a translocation event?
FGFR3-TACC3
What is the abbreviation of the gene that is associated with the V600E mutation?
BRAF
What is the name of the gene that has a mutation at position 34?
H3
What is the name of the gene that is involved in the fusion event?
FGFR3
What is the name of the protein that is associated with the K27(M) mutation?
H3
What is the name of the gene that is not involved in the fusion event?
H3
What is the name of the gene that has a mutation other than the V600E mutation?
H3
Study Notes
Erişkin Tip Difüz Gliyal Tumorlar (Adult Type Diffuse Glioma)
- 2021 classification: Diffusely infiltrating glioma requires IDH1 or IDH2 mutation or loss of ATRX expression or ATRX mutation, or exclusion of 1p/19q codeletion.
Glioblastom Classification
- IDH mutant glioblastoma
- IDH non-mutant glioblastoma
- Giant cell glioblastoma
- Gliosarcoma
- Epithelioid glioblastoma
Oligodendroglioma Classification
- IDH mutant and 1p/19q codeleted oligodendroglioma
- IDH non-mutant oligodendroglioma
- Anaplastic oligodendroglioma, IDH mutant and 1p/19q codeleted
- Anaplastic oligodendroglioma, IDH non-mutant
WHO 2016 Classification Changes
- IDH mutant diffuse astrocytoma
- IDH non-mutant diffuse astrocytoma
- Anaplastic astrocytoma, IDH mutant
- Anaplastic astrocytoma, IDH non-mutant
- Glioblastoma, IDH mutant
- Glioblastoma, IDH non-mutant
Pediatric Type Diffuse Low-Grade Glioma
- Diffuse astrocytoma, MYB or MYBL1 altered
- Diffuse low-grade glioma, MAPK pathway altered
- Diffuse pediatric-type high-grade glioma, IDH and histone mutated
- High-grade glioma, IDH and histone mutated, pediatric type
Grading of IDH-Mutated Gliomas
- Grade 2: Well-differentiated, no anaplasia, no necrosis, CDKN2A homozigot deletion not present
- Grade 3: Focal or intense anaplasia, mitosis present, necrosis and CDKN2A homozigot deletion not present
- Grade 4: Mitosis, vascular proliferation, necrosis, or CDKN2A homozigot deletion present
This quiz covers the essential diagnostic criteria for adult diffuse gliomas, based on the 2021 updates in classification.
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