20 Questions
Which of the following is NOT a characteristic of creatine kinase (CK)?
Predominantly found in the liver
In which type of tissue is CK-MB predominantly present?
Cardiac muscle
Which of the following statements about creatine kinase (CK) is TRUE?
CK is mainly distributed as CK-MM in cardiac muscle
Which biochemical test is specifically used to assess liver function?
Comprehensive Metabolic Panel
Which of the following tests is used to measure tissue breakdown and abnormal enzyme release?
Release of enzymes from diseased or damaged cells
Which test includes the assessment of serum glucose and calcium, in addition to kidney and liver function tests?
Comprehensive Metabolic Panel
Which test specifically includes measurements for total protein, albumin, and bilirubin, among others, as part of its assessment?
Liver Function Tests
What is the primary function of clinical biochemistry?
Analysis of bodily fluids for diagnostic and therapeutic purposes
Which sub-speciality of clinical biochemistry involves the study of hormones and the diagnosis of endocrine disorders?
Clinical endocrinology
In clinical biochemistry, what does 'Therapeutic Drug Monitoring' primarily involve?
Measurement of therapeutic medication levels to optimize dosage
Chromatography is a technique that separates components of a mixture based on their size and charge.
False
Electrophoresis is used to separate and identify proteins, DNA, and RNA based on their size and charge.
True
Spectroscopy uses the interaction of sound with matter to study the properties of biological molecules.
False
Analytical biochemistry primarily involves the study of biochemical components found in a cell or other biological sample.
True
Clinical biochemistry, also known as chemical pathology, is primarily concerned with the genetic analysis of bodily fluids for diagnostic and therapeutic purposes.
False
Urinalysis involves the chemical analysis of urine only, and does not extend to the analysis of other fluids such as cerebrospinal fluid (CSF) and effusions.
True
A comprehensive metabolic panel includes the assessment of sodium, potassium, and chloride levels only.
False
The total protein test is not a part of liver function tests.
False
Gamma-glutamyl transpeptidase (GGT) is not considered a marker of liver injury.
False
The basic metabolic panel includes assessment of blood urea nitrogen (BUN) and creatinine only.
False
Study Notes
- Myocardial infarction (MI) diagnosis requires 2 probable or 3 definite criteria:
- Clinical history: ischaemic chest pain lasting over 20 minutes
- Changes in ECG tracings
- Rise and fall of specific cardiac biomarkers, such as troponin, CK-MB, myoglobin, H-FABP, and BNP
- Cardiac markers are present in muscle and brain, but their distribution varies:
- Creatine kinase (CK) exists as dimers with muscle (MM) and brain (BB) subunits
- Skeletal muscle: predominantly MM, with 1% MB
- Cardiac muscle: around 80% MM, 20% MB
- Brain: predominantly BB
- CK-MB levels increase in myocardial infarction, making it a useful diagnostic marker.
- Near patient testing refers to diagnostic tests performed outside of traditional laboratory settings, often using portable equipment.
- Common clinical biochemical tests include:
- Basic metabolic panel (BMP): urea, electrolytes, and glucose
- Comprehensive metabolic panel: glucose, electrolytes, kidney function, liver function, and proteins
- Liver function tests (LFT) evaluate liver health and damage, measuring parameters such as:
- Proteins: albumin, total protein, and globulin levels
- Bilirubin: direct and indirect
- Enzymes: aspartate transaminase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP)
- Clinical chemistry, also known as clinical biochemistry or medical biochemistry, is a branch of biochemistry focused on diagnosing and treating diseases using bodily fluid analysis.
- Analytical chemistry, a sub-speciality of clinical biochemistry, uses various techniques like chromatography, electrophoresis, and spectroscopy to separate, identify, and quantify biological molecules.
- Clinical biochemistry involves several categories of tests:
- Routine or general chemistry: liver and kidney function tests
- Special chemistry: advanced techniques like electrophoresis and manual testing methods
- Clinical endocrinology: studying hormones and endocrine disorders
- Toxicology: analyzing drugs of abuse and other chemicals
- Therapeutic drug monitoring: measuring medication levels for dosage optimization
- Urinalysis: diagnosing and screening for various diseases using urine analysis
- Faecal analysis: detecting gastrointestinal disorders using faecal samples.
Test your knowledge of the criteria for diagnosing myocardial infarction based on the WHO guidelines. This quiz focuses on the clinical history, ECG tracings, and serum cardiac biomarkers used in the diagnosis.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
