JC Pharmacology Week 6 Chapters 41, 44, 45
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Questions and Answers

A client with type 1 diabetes mellitus is prescribed insulin. Which statement best explains the underlying pathophysiology that necessitates insulin therapy in type 1 diabetes?

  • Insulin resistance at the cellular level prevents glucose uptake, requiring increased insulin doses to compensate.
  • Dietary intake of carbohydrates is too high, leading to chronic hyperglycemia.
  • The liver produces excessive glucose, overwhelming the body's ability to regulate blood sugar levels.
  • The pancreas produces insufficient insulin due to autoimmune destruction of beta cells. (correct)

A patient newly diagnosed with type 2 diabetes mellitus is prescribed metformin. What is the primary mechanism of action by which metformin lowers blood glucose?

  • Inhibiting the absorption of carbohydrates from the small intestine.
  • Stimulating the pancreas to release more insulin.
  • Increasing insulin sensitivity in peripheral tissues and decreasing hepatic glucose production. (correct)
  • Slowing the breakdown of incretin hormones, thereby increasing insulin secretion.

A nurse is caring for a patient receiving insulin lispro. What is the most critical instruction to provide regarding timing of administration in relation to meals?

  • Administer the injection immediately before or after meals. (correct)
  • Administer the injection at bedtime.
  • Administer the injection 1 to 2 hours before meals.
  • Administer the injection 30 minutes before meals.

A patient with diabetes mellitus who also has hypertension and dyslipidemia is prescribed an ACE inhibitor, a statin, and an oral antidiabetic drug. What is the rationale for prescribing an ACE inhibitor and a statin for this patient?

<p>To protect against nephropathy and cardiovascular complications associated with diabetes. (C)</p> Signup and view all the answers

A nurse is teaching a patient about the proper administration of subcutaneous insulin injections. Which of the following instructions is most important to include to prevent lipohypertrophy?

<p>Rotate injection sites within the same general area. (B)</p> Signup and view all the answers

A patient with a history of osteoporosis is prescribed calcitonin. What is the primary mechanism by which calcitonin is expected to improve bone density?

<p>Inhibiting osteoclast activity to decrease bone resorption. (C)</p> Signup and view all the answers

A patient is diagnosed with hypercalcemia secondary to hyperparathyroidism. Which of the following interventions is most appropriate for the initial management of this condition?

<p>Aggressive hydration with intravenous normal saline. (D)</p> Signup and view all the answers

A postmenopausal woman is prescribed alendronate for the treatment of osteoporosis. Which instruction should the nurse emphasize to maximize drug absorption and minimize adverse effects?

<p>Take the medication upon waking with a full glass of water, and remain upright for at least 30 minutes. (B)</p> Signup and view all the answers

A patient with chronic kidney disease is at risk for developing secondary hyperparathyroidism. Which of the following mechanisms contributes to this condition?

<p>Impaired activation of vitamin D resulting in decreased calcium absorption. (D)</p> Signup and view all the answers

A nurse is monitoring a patient receiving teriparatide for the treatment of osteoporosis. What potential adverse effect should the nurse prioritize monitoring for?

<p>Hypercalcemia (A)</p> Signup and view all the answers

A patient with Addison's disease is started on hydrocortisone. Which of the following instructions is most important for the nurse to emphasize regarding medication administration and potential adjustments?

<p>The dose may need to be increased during times of stress, such as illness or surgery. (A)</p> Signup and view all the answers

A patient being treated for Cushing's disease with ketoconazole reports experiencing muscle weakness and an irregular heartbeat. Which electrolyte imbalance should the nurse suspect is most likely contributing to these symptoms?

<p>Hypokalemia (B)</p> Signup and view all the answers

A patient is undergoing testing for adrenal insufficiency. The physician orders a cosyntropin (Cortrosyn) stimulation test. Which result would indicate a primary adrenal insufficiency?

<p>A minimal or absent increase in cortisol levels after cosyntropin administration. (B)</p> Signup and view all the answers

A patient with Cushing's syndrome is prescribed mitotane. What is the primary mechanism by which mitotane helps manage Cushing's syndrome?

<p>Selectively destroying adrenocortical cells. (A)</p> Signup and view all the answers

A patient with Addison's disease is taking fludrocortisone. Which of the following assessment findings would indicate that the patient is experiencing an excessive mineralocorticoid effect?

<p>Increased sodium levels and edema. (C)</p> Signup and view all the answers

A patient taking an amylin analog such as pramlintide acetate reports persistent nausea and a decreased appetite. What is the most appropriate nursing intervention?

<p>Monitor the patient's blood glucose levels closely and educate about the medication's satiety effects. (C)</p> Signup and view all the answers

A patient newly prescribed an incretin mimetic asks about its mechanism of action. Which explanation is most accurate?

<p>It stimulates the pancreas to release insulin in response to elevated blood glucose levels after eating. (A)</p> Signup and view all the answers

A patient with diabetes who is prescribed a new medication reports experiencing a persistent runny nose, sore throat and headache. Which medication is most likely causing these adverse effects?

<p>A medication for upper respiratory tract infection. (D)</p> Signup and view all the answers

A patient taking exenatide reports severe abdominal pain radiating to the back. What is the priority nursing action?

<p>Assess the patient for signs and symptoms of acute pancreatitis and notify the healthcare provider immediately. (C)</p> Signup and view all the answers

A patient with type 1 diabetes is prescribed pramlintide in addition to their insulin regimen. What is the most important instruction regarding the administration of pramlintide?

<p>Monitor blood glucose levels closely, because the medication increases the sense of satiety, possibly reducing food intake and promoting weight loss. (C)</p> Signup and view all the answers

What is the primary difference between type 1 and type 2 diabetes mellitus regarding the necessity of exogenous insulin administration?

<p>Type 1 diabetes always requires exogenous insulin, while approximately 20% of individuals with type 2 diabetes require it at some point. (C)</p> Signup and view all the answers

Which of the following best describes the onset and progression of type 2 diabetes mellitus compared to type 1?

<p>Type 2 diabetes has a gradual onset with less severe initial symptoms, whereas type 1 has a sudden onset. (B)</p> Signup and view all the answers

Which characteristic is most indicative of type 1 diabetes mellitus?

<p>Autoimmune destruction of pancreatic beta cells. (B)</p> Signup and view all the answers

A patient is diagnosed with metabolic syndrome. Which cluster of findings would most strongly support this diagnosis?

<p>Low HDL, abdominal obesity, hypertriglyceridemia, and hypertension. (A)</p> Signup and view all the answers

What factor significantly increases the risk of developing type 2 diabetes mellitus?

<p>Obesity and excessive caloric intake. (B)</p> Signup and view all the answers

In assessing a young male patient suspected of having type 1 diabetes, which age range would align with the peak incidence for males?

<p>Between 12 to 14 years of age. (A)</p> Signup and view all the answers

Why is early diagnosis and management of diabetes mellitus, especially type 1, critical during childhood and adolescence?

<p>To reduce the risk of long-term complications such as cardiovascular disease, neuropathy, and nephropathy. (C)</p> Signup and view all the answers

How does the prevalence of type 2 diabetes mellitus compare to type 1 diabetes mellitus?

<p>Type 2 diabetes accounts for approximately 90% of all diabetes cases. (C)</p> Signup and view all the answers

Following a meal, the pancreas increases insulin secretion. What is the primary initial destination of this secreted insulin?

<p>Portal circulation, with a significant portion transported to the liver. (A)</p> Signup and view all the answers

A patient with diabetes mellitus experiences polyuria. What is the underlying physiological mechanism directly responsible for this?

<p>Hyperglycemia causing osmotic diuresis in the kidneys. (D)</p> Signup and view all the answers

A patient with long-standing diabetes mellitus develops atherosclerosis. Which of the following vascular complications is most likely to arise as a result of this process?

<p>Myocardial infarction. (A)</p> Signup and view all the answers

How does insulin primarily facilitate the reduction of blood glucose levels?

<p>By binding with cellular receptors, allowing rapid entry of glucose into cells. (D)</p> Signup and view all the answers

A patient is newly diagnosed with diabetes and reports experiencing excessive thirst. What term describes this symptom?

<p>Polydipsia. (A)</p> Signup and view all the answers

What happens to circulating insulin after it has performed its function?

<p>It clears from the circulating blood within 10 to 15 minutes. (D)</p> Signup and view all the answers

A patient with diabetes mellitus is found to have glucosuria during a routine checkup. What physiological process directly causes this condition?

<p>Impaired reabsorption of glucose in the kidneys due to hyperglycemia. (D)</p> Signup and view all the answers

How does insulin influence the metabolism of fats and proteins in the body.

<p>Facilitating the conversion of fats to lipids and proteins to amino acids. (D)</p> Signup and view all the answers

A patient with type 2 diabetes is prescribed acarbose. What is the primary mechanism by which acarbose helps to lower postprandial blood glucose levels?

<p>Delaying the digestion of complex carbohydrates in the intestine (A)</p> Signup and view all the answers

A patient with type 2 diabetes is prescribed rosiglitazone. What is the primary mechanism of action of rosiglitazone?

<p>Decreases insulin resistance in peripheral tissues. (D)</p> Signup and view all the answers

A patient taking repaglinide is about to skip a meal. What is the most appropriate nursing action regarding the medication dose?

<p>Hold the dose and instruct the patient to take the next dose with their next meal. (A)</p> Signup and view all the answers

A patient with elevated serum glucose is prescribed sitagliptin. How does sitagliptin lower blood glucose levels?

<p>By increasing incretin hormone levels, which enhances insulin release and reduces hepatic glucose production. (A)</p> Signup and view all the answers

A patient with type 2 diabetes is prescribed acarbose. Which pre-existing condition would be a contraindication to using this medication?

<p>Hepatic disease (D)</p> Signup and view all the answers

A patient is prescribed pioglitazone. Which of the following assessments is most important for the nurse to monitor due to the risks associated with this medication?

<p>Liver function tests (C)</p> Signup and view all the answers

A patient with type 2 diabetes is prescribed both repaglinide and metformin. What is the rationale for prescribing these two antidiabetic medications?

<p>To enhance insulin sensitivity while also stimulating insulin release (A)</p> Signup and view all the answers

A patient with diabetes is prescribed sitagliptin. The nurse understands that sitagliptin helps lower blood glucose by primarily affecting which physiological process?

<p>Enhancing the effects of incretin hormones to stimulate insulin release (D)</p> Signup and view all the answers

Which of the following physiological responses would directly inhibit insulin secretion?

<p>Stimulation of specific adrenergic receptors. (A)</p> Signup and view all the answers

A patient with type 1 diabetes requires insulin therapy. Why is insulin not administered orally?

<p>The acidic environment of the stomach degrades insulin. (B)</p> Signup and view all the answers

A patient is prescribed a rapid-acting insulin analog. Which characteristic is most important for the nurse to consider when educating the patient about its use?

<p>It has a rapid onset of action, requiring administration shortly before or after starting a meal. (D)</p> Signup and view all the answers

Which of the following best describes the preparation and source of human insulin used in the United States?

<p>Synthesized in laboratories, making it structurally identical to endogenous human insulin. (B)</p> Signup and view all the answers

A patient with diabetes is prescribed both regular insulin and an intermediate-acting insulin. What is the rationale for prescribing these two types of insulin?

<p>To immediately correct the blood sugar and maintain the effect for an extended period. (B)</p> Signup and view all the answers

A patient is switched from multiple daily injections of insulin to an insulin pump that delivers a continuous subcutaneous infusion of insulin. Which type of insulin is typically used in insulin pumps?

<p>Rapid-acting insulin to cover both basal and bolus needs. (D)</p> Signup and view all the answers

Which factor can increase blood glucose?

<p>Several hormones (A)</p> Signup and view all the answers

Canagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, works via which primary mechanism to lower blood glucose levels?

<p>Blocking glucose reabsorption in the kidney, increasing urinary glucose excretion. (C)</p> Signup and view all the answers

When administering subcutaneous insulin, what factors influence the absorption rate and, therefore, the onset and duration of action?

<p>The injection site, type of insulin, and depth of injection. (A)</p> Signup and view all the answers

A patient taking canagliflozin reports symptoms of dizziness and lightheadedness upon standing. What is the most appropriate initial nursing intervention?

<p>Encouraging the patient to increase fluid intake and assessing blood pressure. (C)</p> Signup and view all the answers

Why is combination drug therapy becoming increasingly common in the management of type 2 diabetes mellitus?

<p>To target multiple pathophysiological defects of type 2 diabetes with different mechanisms of action. (C)</p> Signup and view all the answers

When initiating combination drug therapy for a patient with type 2 diabetes, what laboratory parameters should be monitored regularly to assess the effectiveness of the treatment?

<p>Fasting plasma glucose and glycosylated hemoglobin (A1C) levels. (D)</p> Signup and view all the answers

A patient with diabetes is prescribed enalapril. What is the primary rationale for using ACE inhibitors like enalapril in diabetic patients?

<p>To protect against diabetic nephropathy and reduce cardiovascular risk. (D)</p> Signup and view all the answers

A patient with diabetes and hypertension is prescribed hydrochlorothiazide. What potential metabolic side effect related to diabetes should the nurse monitor for?

<p>Worsening of insulin resistance and hyperglycemia. (C)</p> Signup and view all the answers

What are the primary goals of antidiabetic therapy?

<p>Maintain blood glucose levels within a normal or near-normal range, promote normal metabolism of carbohydrates, fats, and proteins, and prevent acute and long-term complications. (A)</p> Signup and view all the answers

For a patient with diabetes, what is the rationale for prescribing aspirin as an adjuvant medication?

<p>To prevent cardiovascular events by inhibiting platelet aggregation. (B)</p> Signup and view all the answers

What is the primary mechanism by which vitamin D increases serum calcium levels?

<p>Mobilizing calcium from bone and increasing intestinal absorption. (D)</p> Signup and view all the answers

Which of the following statements accurately describes the role of vitamin D in bone health?

<p>Vitamin D promotes bone formation in addition to raising serum calcium levels. (B)</p> Signup and view all the answers

A patient is diagnosed with hypocalcemia. Which physiological process is most directly affected by this condition?

<p>Impaired nerve and muscle function. (C)</p> Signup and view all the answers

What is a potential long-term consequence of untreated hypocalcemia or hypercalcemia?

<p>Weakened bones leading to fractures. (A)</p> Signup and view all the answers

In addition to vitamin D and calcium supplementation, what lifestyle change is most beneficial in preventing osteoporosis?

<p>Regular weight-bearing exercise. (D)</p> Signup and view all the answers

A patient on chronic corticosteroid therapy is assessed to be at risk of osteoporosis. What is the underlying mechanism by which corticosteroids contribute to bone loss?

<p>Inhibition of osteoblast activity and increased bone resorption. (D)</p> Signup and view all the answers

A patient with a history of smoking is advised to quit to reduce the risk of osteoporosis. How does smoking contribute to the development of osteoporosis?

<p>Smoking impairs calcium absorption and bone formation. (B)</p> Signup and view all the answers

Which statement best describes the relationship between vitamin D, calcium intake, and bone health?

<p>Vitamin D is necessary for calcium absorption, which is essential for bone health. (D)</p> Signup and view all the answers

Which of the following mechanisms is NOT a direct way by which hormones regulate calcium and bone metabolism?

<p>Influencing the production of red blood cells in bone marrow. (B)</p> Signup and view all the answers

A patient with hypocalcemia is likely to experience increased secretion of which hormone?

<p>Parathyroid Hormone (PTH) (C)</p> Signup and view all the answers

How does parathyroid hormone (PTH) affect calcium levels in the kidneys?

<p>Decreases calcium excretion, leading to higher serum calcium levels. (A)</p> Signup and view all the answers

What is the primary stimulus for calcitonin secretion?

<p>High serum ionized calcium levels. (A)</p> Signup and view all the answers

Which of the following accurately describes calcitonin's action in the body?

<p>It lowers serum calcium by inhibiting bone resorption. (A)</p> Signup and view all the answers

A patient has a condition causing chronically elevated serum calcium levels. Which hormone would be most beneficial in managing this condition?

<p>Calcitonin (C)</p> Signup and view all the answers

What is the primary goal of drug therapy in managing calcium imbalances?

<p>To restore normal calcium balance in the body. (B)</p> Signup and view all the answers

How does parathyroid hormone (PTH) influence calcium levels in the intestines?

<p>It indirectly increases calcium absorption by promoting vitamin D activation. (D)</p> Signup and view all the answers

A patient is diagnosed with a condition that impairs the function of the thyroid gland, resulting in decreased calcitonin secretion. What potential electrolyte imbalance is this patient at risk for?

<p>Hypercalcemia (B)</p> Signup and view all the answers

A patient presents with acute, severe hypocalcemia. Which of the following interventions is the most essential and immediate?

<p>Initiating an intravenous (IV) calcium infusion. (A)</p> Signup and view all the answers

A patient with postmenopausal osteoporosis is prescribed calcitonin. What is the intended therapeutic effect of this medication?

<p>Inhibting calcium resorption from bone and promoting bone density. (D)</p> Signup and view all the answers

Which intervention is the priority in the emergency treatment of acute hypercalcemia with severe symptoms or a serum calcium level greater than 14 mg/dL?

<p>Initiating rehydration with intravenous saline solution. (C)</p> Signup and view all the answers

A patient is prescribed alendronate for osteoporosis. What physiological process does alendronate directly influence to increase bone density?

<p>Inhibiting calcium resorption from bone by affecting osteoclast activity. (B)</p> Signup and view all the answers

Why is intravenous (IV) 0.9% sodium chloride administered in the treatment of hypercalcemia?

<p>To promote calcium excretion through increased urine output. (C)</p> Signup and view all the answers

What is the rationale for administering corticosteroids in the treatment of hypercalcemia?

<p>To reduce inflammation-induced bone resorption, which contributes to elevated serum calcium levels. (B)</p> Signup and view all the answers

A 72-year-old patient is diagnosed with hypocalcemia secondary to vitamin D deficiency. Considering the recommended dietary allowance of vitamin D, what daily intake should the nurse recommend?

<p>20 mcg/day (D)</p> Signup and view all the answers

What is the primary purpose of the overnight dexamethasone suppression test in the context of Cushing's disease?

<p>To assess the degree of suppression of cortisol by exogenous glucocorticoids. (C)</p> Signup and view all the answers

Why is combination therapy with both mineralocorticoids and adrenocorticoids essential in the treatment of Addison's disease?

<p>To replace the deficient hormones in both the glucocorticoid and mineralocorticoid pathways. (A)</p> Signup and view all the answers

In the drug therapy for Cushing's disease, medications aim to inhibit one or more enzymes involved in cortisol synthesis. Which drug exemplifies an 11-Deoxycortisol inhibitor used in this process?

<p>Ketoconazole (C)</p> Signup and view all the answers

A patient with Cushing's disease is being treated with mitotane. What specific monitoring should be prioritized to assess the drug's effectiveness and prevent potential complications?

<p>Monitoring of serum cortisol levels to assess the degree of adrenal suppression. (B)</p> Signup and view all the answers

When providing patient teaching for individuals on long-term hydrocortisone therapy for Addison's disease, what is the most important instruction regarding medication adjustments during periods of stress or illness?

<p>Increase the dose as directed by their healthcare provider to mimic the body's natural response to stress. (D)</p> Signup and view all the answers

Which feedback mechanism primarily regulates adrenocortical hormone secretion under normal, non-stressful conditions?

<p>A negative feedback system involving the hypothalamus, anterior pituitary, and adrenal cortex. (C)</p> Signup and view all the answers

In Addison's disease, the adrenal cortex is damaged, leading to decreased production of its hormones. Which of the following etiologies is the MOST common cause of primary adrenal insufficiency?

<p>Autoimmune destruction of the adrenal cortex (D)</p> Signup and view all the answers

A patient with Addison's disease is MOST likely to exhibit signs and symptoms directly related to a deficiency in which hormones?

<p>Decreased levels of cortisol, aldosterone, and androgens. (D)</p> Signup and view all the answers

A patient with adrenal cortex insufficiency is likely to experience a range of clinical manifestations. Which of the following clinical manifestations is the MOST directly related to the loss of sodium and water?

<p>Dehydration, weakness, and fatigue (B)</p> Signup and view all the answers

In a patient with secondary adrenocortical insufficiency caused by hypopituitarism, which hormonal change is the PRIMARY underlying cause of the adrenal cortex dysfunction?

<p>Decreased stimulation of the adrenal cortex due to reduced ACTH secretion (B)</p> Signup and view all the answers

Which of the following conditions would be MOST indicative of primary adrenocortical insufficiency rather than secondary adrenocortical insufficiency?

<p>Hyperpigmentation of the skin and mucous membranes (A)</p> Signup and view all the answers

A patient with suspected adrenocortical insufficiency undergoes diagnostic testing. Which set of laboratory findings would BEST support a diagnosis of PRIMARY adrenal insufficiency?

<p>Low serum cortisol, elevated plasma ACTH (C)</p> Signup and view all the answers

Following a bilateral adrenalectomy, what hormone replacement strategy is MOST crucial for the immediate survival and long-term well-being of the patient?

<p>Combination of mineralocorticoid and glucocorticoid replacement. (D)</p> Signup and view all the answers

A patient with Addison's disease is admitted to the emergency department after experiencing a sudden onset of severe nausea, vomiting, and hypotension. Which underlying physiological process is most likely contributing to these symptoms?

<p>A deficiency in both glucocorticoids and mineralocorticoids leading to fluid and electrolyte imbalances. (B)</p> Signup and view all the answers

A patient with known Addison's disease presents to the clinic for a routine follow-up. The patient mentions experiencing an unusual craving for salty foods. How does this relate to their underlying condition?

<p>It's a typical manifestation of Addison's disease due to aldosterone deficiency. (B)</p> Signup and view all the answers

During the assessment of a patient with Cushing's disease, a nurse notes the presence of thin, fragile skin, easy bruising, and broad purple striae on the abdomen. What is the underlying pathophysiological mechanism that explains these clinical findings?

<p>Elevated cortisol levels leading to protein catabolism and connective tissue weakening. (B)</p> Signup and view all the answers

A female patient diagnosed with Cushing's disease reports increased facial hair and a deepening of her voice. Which hormonal imbalance primarily accounts for these changes?

<p>Elevated androgen levels due to excessive adrenal androgens. (A)</p> Signup and view all the answers

A patient with Cushing's disease is at an increased risk for developing osteoporosis and fractures. Which physiological mechanism explains this increased risk?

<p>Cortisol-induced reduction in bone formation and increased bone resorption. (D)</p> Signup and view all the answers

A patient with Cushing's syndrome is diagnosed with impaired wound healing following a surgical procedure. What is the primary mechanism by which excessive cortisol levels contribute to this delayed healing process?

<p>Suppressed inflammatory response and reduced immune function. (A)</p> Signup and view all the answers

A patient diagnosed with Cushing's syndrome reports experiencing persistent and worsening depression. How do elevated cortisol levels contribute to the development of depressive symptoms?

<p>Cortisol affects neurotransmitter function, stress response, and brain structure. (D)</p> Signup and view all the answers

A patient is suspected of having adrenocortical insufficiency. The provider orders a diagnostic test to confirm this diagnosis. Which test would be most appropriate to confirm adrenocortical insufficiency?

<p>A short plasma cortisol test. (D)</p> Signup and view all the answers

Flashcards

Type 1 Diabetes Mellitus

An autoimmune condition where the body does not produce insulin.

Type 2 Diabetes Mellitus

A condition characterized by insulin resistance and relative insulin deficiency.

Insulin Action

Insulin lowers blood glucose levels by facilitating cellular uptake of glucose.

Sulfonylureas

Oral antidiabetic drugs that stimulate insulin secretion from the pancreas.

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Adverse Effects of Antidiabetic Drugs

Potential negative reactions from medications like hypoglycemia and weight gain.

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Role of Parathyroid Hormone

Parathyroid hormone regulates calcium levels in the blood by increasing calcium reabsorption and mobilization from bones.

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Calcitonin Function

Calcitonin lowers blood calcium levels by inhibiting osteoclast activity and promoting calcium deposition in bones.

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Vitamin D Role

Vitamin D enhances calcium absorption in the intestines and promotes bone health.

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Bisphosphonates Prototype

Bisphosphonates are drugs that prevent bone resorption and are used to treat osteoporosis by inhibiting osteoclasts.

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Management of Hypercalcemia

Managing hypercalcemia involves hydration, diuretics, and medications to lower calcium levels as it is a medical emergency.

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Addison disease

A condition where the adrenal glands do not produce enough hormones, leading to symptoms like fatigue and weight loss.

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Cushing disease

A disorder caused by excessive cortisol production, leading to weight gain, high blood pressure, and skin changes.

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Corticotropin (ACTH) usage

ACTH is used to diagnose adrenocortical insufficiency by stimulating adrenal hormone production.

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Cosyntropin (Cortrosyn) usage

Cosyntropin, a synthetic ACTH, is also used to diagnose adrenal insufficiency by measuring cortisol response.

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Nursing process for Addison/Cushing

Involves assessment, diagnosis, planning, implementation, and evaluation for patients with these disorders.

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Hyperglycemia

A high blood sugar condition often seen in diabetes mellitus.

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Glycosuria

Presence of glucose in urine, indicating high blood sugar.

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Polydipsia

Abnormal thirst, commonly associated with diabetes.

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Polyuria

Excessive urination, a symptom of diabetes mellitus.

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Diabetic Ketoacidosis (DKA)

A serious complication of diabetes caused by high ketones and glucose levels.

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Complications of Diabetes

Potential health issues from diabetes, including heart disease and kidney failure.

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Insulin Function

Insulin helps lower blood glucose by enabling glucose entry into cells.

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Metabolic Abnormalities in Diabetes

Conditions like insulin resistance and fat metabolism disruption in diabetes.

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Insulin Administration

Exogenous insulin is necessary for managing Type 1 Diabetes Mellitus due to lack of insulin production.

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Sudden Onset (Type 1)

Type 1 Diabetes typically has a sudden onset, with peak incidence in early adolescence.

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Gradual Onset (Type 2)

Type 2 Diabetes usually has a gradual onset with less severe symptoms compared to Type 1.

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Risk Factors for Type 2

Obesity and metabolic syndrome factors like high triglycerides and hypertension increase Type 2 Diabetes risk.

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Exogenous Insulin in Type 2

Approximately 20% of those with Type 2 Diabetes eventually require exogenous insulin for management.

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Insulin Secretion Stimulus

Glucose is the major stimulus for insulin secretion from pancreatic beta cells.

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Insulin Type

Insulin is a protein hormone, not a lipid hormone, secreted by the pancreas.

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Insulin Administration Routes

Insulin cannot be taken orally; it's mostly administered subcutaneously, with some types given intravenously.

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Rapid-Acting Insulin

This type of insulin has a rapid onset (15 min or less) and lasts for 4 to 8 hours.

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Insulin Concentration

The standard concentration for insulin in the U.S. is U-100.

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Insulin Types

Insulin analogs are synthetically produced by altering the amino acid sequence of natural insulin.

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Insulin Preparation Types

Insulin can be classified as rapid, intermediate, and long-acting based on absorption and duration of action.

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Hormones Raising Blood Glucose

Several hormones, including certain adrenergic receptors, can inhibit insulin secretion during stress conditions.

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Adverse Effects of Pramlintide Acetate

Common side effects include hypoglycemia, nausea, and headaches when using pramlintide acetate.

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Amylin Analogs Mechanism

They suppress glucagon secretion after meals to help regulate blood glucose levels.

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Indications for Using Incretin Mimetics

Used to manage postprandial glucose levels by stimulating insulin secretion from the pancreas.

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Common Adverse Effects of Incretin Mimetics

These include gastrointestinal distress and the risk of acute pancreatitis.

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Nursing Process Implications for Diabetes Medications

Includes monitoring blood sugars frequently and being aware of side effects like hypoglycemia.

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Acarbose

An alpha-glucosidase inhibitor that delays carbohydrate digestion.

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Acarbose Indications

Used to decrease postprandial glucose levels, possibly with insulin or oral agents.

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Acarbose Adverse Effects

Can cause hypoglycemia, gastric upset, leukopenia, thrombocytopenia, and anemia.

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Rosiglitazone Mechanism

Decreases insulin resistance, but poses heart failure risks.

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Sitagliptin

A dipeptidyl peptidase 4 inhibitor that increases incretin hormones to boost insulin release.

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Repaglinide Mechanism

Stimulates pancreatic insulin secretion to manage high glucose levels.

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Meglitinides

Class of drugs (e.g., Repaglinide) that stimulate insulin release from the pancreas.

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Thiazolidinediones

Class of drugs that improve insulin sensitivity; caution due to heart failure risks.

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Canagliflozin

A medication that blocks glucose absorption in the kidney, increasing glucose excretion.

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Combination Drug Therapy

Using multiple medications to achieve better glycemic control in diabetes beyond diet and exercise.

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ACE Inhibitors

Medications that help relax blood vessels and lower blood pressure, e.g., enalapril.

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Thiazide-like Diuretics

Diuretics that help reduce blood pressure and fluid retention, e.g., hydrochlorothiazide.

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Blood Glucose Goals

Maintaining blood sugar levels at or near normal to prevent complications.

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Adverse Effects of Canagliflozin

Potential negative reactions include dehydration, hypotension, and syncope.

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Monitoring Glycemic Control

Regular checking of fasting plasma glucose and glycosylated hemoglobin levels to assess diabetes management.

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Insulin Therapy Initiation

Starting insulin treatment when oral medications fail to achieve adequate blood sugar control.

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Regulation of Calcium Metabolism

Three hormones regulate calcium and bone metabolism: PTH, calcitonin, and vitamin D.

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Parathyroid Hormone (PTH)

PTH is stimulated by low serum calcium levels to increase calcium in bones, intestines, and kidneys.

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Calcitonin

Calcitonin is secreted by the thyroid gland to lower serum calcium levels during hypercalcemia.

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Hypocalcemia Effects

Low serum calcium levels can lead to increased PTH secretion and symptoms like tetany.

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Hypercalcemia Response

High serum calcium levels trigger hormonal responses to reduce calcium levels in the body.

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Calcium Absorption

Hormones regulate the absorption of dietary calcium from the GI tract for proper metabolism.

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Calcium Excretion

Hormones also control the excretion of calcium via the kidneys to maintain balance.

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Hypocalcemic Drugs

Medications that correct calcium deficits, reduce tetany risk, and slow osteoporosis.

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Hypercalcemic Drugs

Medications that help manage high calcium levels and treat underlying conditions.

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Calcium and Vitamin D Supplements

Used to prevent and treat hypocalcemia and osteoporosis.

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Bisphosphonates

Drugs that inhibit calcium resorption from bones and treat osteoporosis; prototype is alendronate.

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Emergency Hypercalcemia Treatment

Involves IV saline infusion to rehydrate and maintain urine output if serum calcium is dangerously high.

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Recommended Vitamin D Intake

15 mcg/day for ages 1-70; 20 mcg/day for adults 71+; 10 mcg/day for infants.

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Acute Severe Hypocalcemia Treatment

Intravenous calcium administration is critical to treat acute and severe cases of hypocalcemia.

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Vitamin D

A fat-soluble vitamin that raises serum calcium levels and promotes bone formation.

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Hypocalcemia

A condition of low calcium levels that can weaken bones and lead to fractures.

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Hypercalcemia

A condition of high calcium levels that can lead to serious health issues.

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Osteoporosis Prevention

Includes dietary measures, medications, exercise, and lifestyle changes.

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Role of Vitamin D

Enhances intestinal calcium absorption and promotes bone health.

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Chronic Corticosteroid Therapy

Medication that can contribute to osteoporosis due to calcium loss.

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Adrenal Cortex Hormones

Hormones that are essential for maintaining body homeostasis.

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Adrenocortical Insufficiency

A condition marked by insufficient adrenal hormone production.

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Negative Feedback System

Regulatory mechanism that controls hormone secretion based on body needs.

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Clinical Manifestations of Adrenocortical Insufficiency

Symptoms include weakness, dehydration, and decreased cardiac output.

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Primary vs Secondary Adrenocortical Insufficiency

Primary is due to adrenal issues; secondary is from pituitary problems.

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Corticosteroid Secretion

Vital to maintain homeostasis when secreted adequately.

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Stimuli of Hormone Secretion

Secretion varies based on different body needs and stimuli.

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Acute Adrenal Crisis

Life-threatening condition from insufficient adrenal hormones during stress.

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Addison Disease Symptoms

Includes nausea, vomiting, muscle weakness, and hypotension.

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Confirming Adrenocortical Insufficiency

Requires either a short plasma test or high-dose test.

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Cushing Disease Causes

Results from excessive corticotropin or cortisol-secreting tumors.

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Cushing Disease Symptoms

Includes moon facies, buffalo hump, fragile skin, and purple striae.

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Effects of Cushing Disease on Females

Includes masculine traits, diminished libido, and depression.

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Diagnosis of Cushing Disease

Diagnosis can involve fasting glucose tests, but is not solely reliant on it.

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Complications of Cushing Disease

Include osteoporosis, fractures, and peptic ulcers.

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Cushing Disease Diagnosis

Requires an overnight dexamethasone suppression test to confirm.

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Drugs for Addison Disease

Combination of mineralocorticoid and adrenocorticoid must be replaced; hydrocortisone is the prototype.

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Cushing Disease Treatment

Goal is to inhibit cortisol synthesis; uses glucocorticoid receptor antagonists and inhibitors like ketoconazole.

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Nursing Process Steps

Involves assessment, diagnosis, planning, intervention, and evaluation for patient care.

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Patient Teaching in Addison Disease

Educate on the importance of lifelong hormone replacement and monitor for adverse effects.

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Study Notes

Learning Objectives for Diabetes Mellitus Treatment

  • Differentiate between type 1 and type 2 diabetes mellitus
  • Identify clinical manifestations of type 1 and type 2 diabetes
  • Identify insulin prototype actions, uses, adverse effects, contraindications, and nursing implications
  • Discuss features of various insulin types and insulin analogs
  • Identify oral antidiabetic drug prototypes, actions, uses, adverse effects, contraindications, and nursing implications
  • Identify prototypes and describe actions, uses, adverse effects, contraindications, and nursing implications for sulfonylureas, alpha-glucosidase inhibitors, biguanides, thiazolidinediones, meglitinides, DPP-4 inhibitors, amylin analogs, incretin mimetics, and sodium-glucose cotransporter 2 inhibitors
  • Apply pharmacokinetics, pharmacodynamics, and pharmacotherapeutics of ACE inhibitors, angiotensin II receptor blockers, and statins in diabetic care
  • Implement nursing process for diabetes patients in receiving medications, explaining benefits, assisting patients/caregivers in diabetes management, administering medications and assessing/monitoring adherence to treatment strategies
  • Differentiate between type 1 and type 2 diabetes mellitus
  • Discuss characteristics of various types of insulins and insulin analogs

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Description

Explore treatments for diabetes mellitus, including insulin types and oral antidiabetic drugs. Learn about actions, uses, and nursing implications of drugs like sulfonylureas, ACE inhibitors and statins in managing diabetes. Differentiate between type 1 and type 2 diabetes and their clinical manifestations.

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