Diabetes Mellitus Overview
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Questions and Answers

What is a primary characteristic of Type 1 Diabetes Mellitus (DM)?

  • Increased hepatic glucose production
  • Defects in insulin action
  • Variable degrees of insulin resistance
  • Autoimmunity against insulin-producing beta cells (correct)
  • Which of the following best describes Type 2 Diabetes Mellitus (DM)?

  • A heterogeneous group of disorders with varying degrees of insulin resistance and secretion deficits. (correct)
  • A condition primarily characterized by single gene defects.
  • A condition resulting exclusively from mitochondrial abnormalities.
  • A homogenous condition caused by autoimmunity.
  • What is a shared characteristic between Type 1 and Type 2 diabetes regarding their progression?

  • Sudden onset of hyperglycemia.
  • Consistent insulin secretion.
  • Immediate insulin deficiency
  • A period of progressively worsening glucose homeostasis. (correct)
  • Which of the following is NOT explicitly listed as an etiology of diabetes mellitus?

    <p>Increased physical exercise. (A)</p> Signup and view all the answers

    What is the primary result of the defects in insulin action or secretion that are characteristic of Type 2 diabetes?

    <p>Hyperglycemia (C)</p> Signup and view all the answers

    What is the primary characteristic of diabetes mellitus?

    <p>Hyperglycemia in the absence of treatment (B)</p> Signup and view all the answers

    Which of the following is NOT a long-term specific complication of diabetes mellitus?

    <p>Myopathy (D)</p> Signup and view all the answers

    Besides the specific complications, what other diseases are people with diabetes at increased risk for?

    <p>Cardiovascular disease, peripheral arterial disease, and cerebrovascular disease (C)</p> Signup and view all the answers

    What are the major factors contributing to hyperglycemia in diabetes mellitus?

    <p>Reduced insulin secretion, decreased glucose utilization, and increased glucose production (A)</p> Signup and view all the answers

    In the United States, diabetes mellitus is the leading cause of all the following EXCEPT:

    <p>Chronic Obstructive Pulmonary disease (COPD) (B)</p> Signup and view all the answers

    Which of the following is a major cause of morbidity and mortality in people with diabetes?

    <p>Cardiovascular disease (B)</p> Signup and view all the answers

    According to the classification of diabetes mellitus, how many broad categories are there?

    <p>Two (D)</p> Signup and view all the answers

    What is the fundamental basis for classifying diabetes mellitus?

    <p>The pathogenic process leading to hyperglycemia (C)</p> Signup and view all the answers

    Which of the following is NOT a typical symptom associated with Maturity-Onset Diabetes of the Young (MODY)?

    <p>Decreased appetite (C)</p> Signup and view all the answers

    According to the provided information, at what age should asymptomatic adults be screened for diabetes every three years?

    <p>Age ≥ 40 years (C)</p> Signup and view all the answers

    Which of the following is NOT an indication for screening for diabetes in asymptomatic adults?

    <p>Blood pressure of 130/80 mmHg (D)</p> Signup and view all the answers

    What is the diagnostic criterion for gestational diabetes based on a 2-hour post-load plasma glucose test?

    <p>153 - 198 mg/dl (D)</p> Signup and view all the answers

    A patient presents with intense thirst, frequent urination, and visual blurring. Which of the following would NOT fall under the signs of diabetes?

    <p>Blurred vision (C)</p> Signup and view all the answers

    Which of the following is a typical characteristic of Type 1 Diabetes Mellitus at the initial presentation?

    <p>Requirement of insulin as the initial therapy (C)</p> Signup and view all the answers

    An individual with which of the following triglyceride levels should be screened for diabetes?

    <p>Triglyceride &gt; 250mg/dl (A)</p> Signup and view all the answers

    What fasting plasma glucose level is considered diagnostic for gestational diabetes?

    <p>92-125 mg/dl (D)</p> Signup and view all the answers

    What is the recommended initial treatment for patients with Type 2 diabetes who do not achieve desired glycemic control with diet and exercise?

    <p>Metformin (A)</p> Signup and view all the answers

    Which of the following dietary changes should be avoided in managing Type 2 diabetes?

    <p>Consuming more saturated fats (D)</p> Signup and view all the answers

    What is the maximum recommended alcohol intake for women per day?

    <p>One drink (A)</p> Signup and view all the answers

    What should be the initial dose of Metformin when starting treatment?

    <p>500mg PO at bedtime (A)</p> Signup and view all the answers

    Which medication may cause weight gain and hypoglycemia when used as initial treatment for Type 2 diabetes?

    <p>Second-generation sulfonylureas (C)</p> Signup and view all the answers

    Under what condition should insulin therapy be considered for a patient with Type 2 diabetes?

    <p>When there are symptoms of diabetes or HbA1c is greater than 9% (D)</p> Signup and view all the answers

    What is advised if a patient's BMI is greater than 25 kg/m2?

    <p>Advise at least 5% weight loss (C)</p> Signup and view all the answers

    What dietary recommendation is suggested for people managing Type 2 diabetes?

    <p>Eat a diet rich in vegetables and 1-2 servings of fruit per day (C)</p> Signup and view all the answers

    What is the initial management step for patients with Type 1 Diabetes Mellitus (DM)?

    <p>Initiate subcutaneous insulin injections as soon as possible (A)</p> Signup and view all the answers

    What is the recommended insulin adjustment when a Type 2 DM patient requires a bedtime insulin dose greater than 20 units?

    <p>Split the dose into morning and evening doses (2/3rd am and 1/3rd pm) (A)</p> Signup and view all the answers

    How frequently should patients with well-managed blood glucose levels be followed up?

    <p>Every 3 months (B)</p> Signup and view all the answers

    What should be monitored in Type 2 DM patients who are not on insulin?

    <p>Self-monitoring of blood glucose when there are medication or lifestyle changes (C)</p> Signup and view all the answers

    What type of education is essential for patients with Type 1 DM?

    <p>Education on diabetes, insulin, hypoglycemia, and chronic complications (D)</p> Signup and view all the answers

    When should fasting and postprandial blood glucose measurements be taken for patients on insulin?

    <p>As frequently as possible (A)</p> Signup and view all the answers

    What should be the frequency of HbA1c testing for those who have it available?

    <p>2-4 times a year (B)</p> Signup and view all the answers

    What is a key indicator of the need for more frequent follow-up in diabetes management?

    <p>Recent illness or complications development (D)</p> Signup and view all the answers

    Which of the following is a feature of Diabetic Ketoacidosis (DKA)?

    <p>Hyperglycemia with BG ≥250 mg/dL (C)</p> Signup and view all the answers

    What is the first step in the initial management of DKA?

    <p>Start IV Fluids with 1 bag of normal saline (D)</p> Signup and view all the answers

    Identify the plasma glucose level that defines hypoglycemia.

    <p>70 mg/dL (B)</p> Signup and view all the answers

    Which symptom is commonly associated with hypoglycemia?

    <p>Dizziness (C)</p> Signup and view all the answers

    What should be administered when blood glucose is below 70 mg/dL?

    <p>Oral glucose 20g (B)</p> Signup and view all the answers

    Which of the following management steps is recommended for a hemodynamically unstable patient with DKA?

    <p>Give 1 L normal saline over 30 minutes (C)</p> Signup and view all the answers

    What does Ketonuria >1+ indicate in relation to DKA?

    <p>Significant ketone production (A)</p> Signup and view all the answers

    What complication is often associated with the treatment of diabetic patients using insulin or sulfonylurea?

    <p>Hypoglycemia (D)</p> Signup and view all the answers

    Flashcards

    What is Diabetes Mellitus?

    Diabetes mellitus is a group of metabolic disorders characterized by high blood sugar levels, either due to the body not producing enough insulin, the body not using insulin properly, or both.

    Diabetes Epidemiology

    Diabetes is a growing global concern, affecting millions worldwide. It's a complex disease with a variety of complications, ranging from vision loss to kidney failure.

    Type 1 Diabetes

    Type 1 diabetes occurs when the body's immune system attacks and destroys the insulin-producing cells in the pancreas.

    Type 2 Diabetes

    Type 2 diabetes develops when the body doesn't use insulin properly, leading to a buildup of glucose in the bloodstream.

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    Gestational Diabetes

    Gestational diabetes develops during pregnancy when the body cannot produce enough insulin to meet the needs of the growing fetus.

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    Diabetes Complications

    Diabetes can lead to a range of complications, including damage to the eyes, kidneys, nerves, and blood vessels. Many complications are preventable through good management.

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    Diabetes Management Strategies

    To manage diabetes, lifestyle modifications like regular physical activity and a healthy diet are crucial. Medications and insulin therapy may also be required.

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    Preventing Diabetes

    Preventing diabetes involves adopting a healthy lifestyle, including regular exercise, a balanced diet, maintaining a healthy weight, and avoiding smoking.

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    Prediabetes

    A period before the development of diabetes, where glucose regulation worsens gradually.

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    Hyperglycemia

    A situation where blood sugar levels are abnormally high, often a defining characteristic of diabetes.

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    Other Types of Diabetes

    Diabetes caused by specific genetic defects affecting insulin secretion or action, metabolic issues impairing insulin secretion, mitochondrial dysfunction, or other conditions affecting glucose tolerance.

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    What is Maturity-onset diabetes of the young (MODY)?

    A subtype of diabetes characterized by autosomal dominant inheritance, early onset of hyperglycemia, polydipsia, polyphagia, unexplained weight loss or fatigue.

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    What is monogenic diabetes?

    A subtype of diabetes caused by a genetic mutation, typically affecting individuals at a younger age.

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    What is prediabetes?

    A condition where blood sugar levels are higher than normal but not yet high enough to be diagnosed with diabetes.

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    What is gestational diabetes?

    A type of diabetes that develops during pregnancy and typically resolves after delivery.

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    What is Type 1 diabetes?

    A type of diabetes where the body's immune system attacks and destroys the insulin-producing cells in the pancreas.

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    What is Type 2 diabetes?

    A type of diabetes where the body either doesn't produce enough insulin or can't use the insulin it produces effectively.

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    What is a key symptom of early diabetes?

    Frequent urination, usually exceeding 3 liters per day, could be an indicator of diabetes.

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    Who should be screened for diabetes?

    Individuals with a first-degree relative with diabetes and a BMI ≥ 25 kg/m2 should undergo regular diabetes screening.

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    Healthy Dietary Advice for Diabetes

    A diet that emphasizes whole foods, such as fruits, vegetables, and whole grains, while limiting processed foods and added sugars.

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    What is Metformin?

    A type of medication commonly used as the first-line treatment for type 2 diabetes, known for not causing weight gain or low blood sugar.

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    What are Sulfonylureas?

    A group of medications that help the pancreas release more insulin to lower blood sugar. However, they can cause weight gain and low blood sugar.

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    What is HbA1c?

    A measure of how well your blood sugar is controlled over a period of time, often used by doctors to monitor diabetes management.

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    What is Intensification of Treatment?

    The process of adjusting medication dosages or adding new treatments to better control blood sugar levels.

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    What is Hypoglycemia?

    A serious condition where blood sugar drops too low, often caused by medications or missing meals. It can lead to dizziness, confusion, and even seizures.

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    What is Overweight?

    A health condition characterized by a Body Mass Index (BMI) of 25 or higher, indicating excess weight.

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    Importance of lifestyle changes in diabetes

    Quitting smoking and alcohol use is vital, especially when managing diabetes. It can significantly improve health outcomes and reduce diabetes complications.

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    Insulin initiation in type 2 diabetes

    If lifestyle modifications and oral medications aren't enough to control blood sugar in type 2 diabetes, insulin therapy is often added. Start with NPH insulin at bedtime and gradually increase the dose based on fasting blood sugar levels.

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    Insulin therapy for type 1 diabetes

    Type 1 diabetes requires immediate insulin therapy. A combination of long/intermediate-acting insulin and rapid-acting insulin is usually prescribed to manage blood sugar throughout the day.

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    Diabetes education for patients

    Patients with diabetes need to be educated on the disease, their medications, how to recognize and manage hypoglycemia, as well as potential long-term complications. Diet and exercise are crucial.

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    Monitoring diabetes patients

    Patients with diabetes should be monitored regularly. Check HbA1c 2-4 times a year to evaluate long-term blood sugar control. More frequent monitoring may be necessary if there are changes in medications, hypoglycemia, recent illness, or complications.

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    Self-monitoring of blood glucose (SMBG)

    Frequent blood sugar monitoring with a glucometer is recommended for both type 1 and type 2 diabetes (especially when on insulin). This helps track blood sugar fluctuations and adjust medication doses if necessary.

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    SMBG in type 2 diabetes without insulin

    Patients with type 2 diabetes not on insulin may only need to monitor their blood sugar when making diet or exercise changes, when medications are adjusted, or if their HbA1c is abnormal despite normal fasting blood sugar.

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    Fasting and postprandial blood sugar monitoring

    Monitor blood sugar levels before meals (fasting) and after meals (postprandial) to detect fluctuations and adjust medication or insulin doses if necessary.

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    Diabetic Ketoacidosis (DKA)

    A condition in which the body produces excess ketones due to a lack of insulin, leading to a high blood glucose level, acidic blood, and dehydration. It usually develops rapidly, within a few hours or days, and is a serious and potentially life-threatening complication of type 1 diabetes.

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    Hyperosmolar Hyperglycemic State (HHS)

    Characterized by extremely high blood glucose levels (generally above 600 mg/dL), dehydration, and a change in mental status. It typically develops more slowly than DKA, often over several days, and mostly affects individuals with type 2 diabetes.

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    Polyuria

    Excessive urination, often resulting from high blood glucose causing the kidneys to try to eliminate excess sugar.

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    Polydipsia

    Excessive thirst, often driven by dehydration caused by polyuria (frequent urination).

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    Fruity odor

    A sweet, fruity odor on the breath, often associated with DKA, caused by the breakdown of ketones.

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    Symptoms of Hypoglycemia

    Symptoms of hypoglycemia include headache, hunger, irritability, anxiety, tingling sensations, rapid heartbeat, sweating, trembling, difficulty speaking, confusion, uncoordinated movements, stupor, paleness, seizures, and coma.

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    Hypoglycemia Management

    Treatment of hypoglycemia involves administering glucose to quickly raise the blood sugar level. This can be done orally with sugar, candy, or dextrose solution, or intravenously if the patient is unable to swallow.

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    Study Notes

    Diabetes Mellitus

    • Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia in the absence of treatment.
    • The pathophysiology is heterogeneous, involving defects in insulin secretion, insulin action, or both.
    • Long-term complications include retinopathy, nephropathy, and neuropathy.
    • People with diabetes have an increased risk of cardiac, peripheral arterial, and cerebrovascular diseases, as well as cataracts, erectile dysfunction, and non-alcoholic fatty liver disease.
    • The risk of infectious diseases such as tuberculosis is also increased.
    • Contributing factors to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production.
    • The metabolic dysregulation in DM causes secondary pathophysiologic changes in multiple organ systems, placing a significant burden on individuals and the healthcare system.
    • In the US, diabetes is the leading cause of end-stage renal disease (ESRD).
    • Non-traumatic lower extremity amputations and adult blindness are also associated risks.
    • Diabetes is a leading cause of mortality, frequently listed as the seventh leading cause of death in the US.

    Classification of DM

    • Diabetes is classified based on the pathogenic process leading to hyperglycemia.
    • Two broad categories are type 1 and type 2 DM.
    • Other forms of diabetes exist, showing increasing recognition and better understanding of molecular pathogenesis.
    • These atypical forms may share features of both type 1 and type 2 DM but are distinct from monogenic forms.
    • Type 1 DM typically develops due to autoimmunity against insulin-producing beta cells, resulting in insulin deficiency.
    • Type 2 DM is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased hepatic glucose production. This commonly links to defects in insulin action and/or secretion.

    Gestational DM

    • Gestational diabetes mellitus (GDM) is glucose intolerance developing during the second or third trimester of pregnancy.
    • Insulin resistance during pregnancy is linked to increased insulin demands, potentially leading to impaired glucose tolerance (IGT) or diabetes.
    • The American Diabetes Association (ADA) classifies diabetes diagnosed in the first trimester as preexisting pregestational diabetes, rather than GDM.
    • Most women with GDM revert to normal glucose tolerance postpartum but have a substantial risk of developing diabetes within 10-20 years.
    • Children born to mothers with GDM display an increased risk of developing metabolic syndrome and type 2 DM.

    Atypical Diabetes

    • Some diabetes forms exhibit features of both type 1 and type 2, but are distinct from monogenic forms.
    • Prepubertal onset of type 2 diabetes and ketosis-prone diabetes in lean individuals are examples.
    • A majority of atypical diabetes cases are African American or Asian.
    • Research is actively pursuing mechanisms for atypical forms of diabetes.

    Epidemiology and Global Considerations

    • The global prevalence of DM has risen significantly. In 2019, the number of cases worldwide was estimated at 463 million with predictions of 642 million by 2040.
    • The type 2 prevalence rate is increasing rapidly, likely due to dietary changes, increasing obesity, reduced activity, and population aging.
    • The rate of type 1 DM is also increasing, although the reasons are less understood, but it is frequently diagnosed in younger individuals.
    • Countries in Scandinavia, followed by Sardinia and Portugal, show the highest rates of type 1 DM, whereas the lowest rates are found in the Pacific Rim.
    • Northern Europe and the United States show intermediate rates.
    • The prevalence of both total diabetes and type 2 diabetes/IGT are highest in certain Pacific islands and the Middle East, and intermediate in countries like India and the United States.
    • Onset of type 2 DM tends to occur at a younger age in ethnic groups other than non-Hispanic white individuals, particularly in Asia.

    Common Symptoms of DM

    • Thirst
    • Frequent urination
    • Blurring of vision
    • Fatigue

    Signs of Diabetes

    • Unintentional weight loss
    • Signs of acute metabolic deterioration (severe dehydration, respiratory distress)
    • Vomiting
    • Altered consciousness level
    • Clinical signs of chronic complications (acute coronary disease, stroke, kidney disease, vision loss, diabetic foot)

    Diagnostic Criteria for Diabetes Mellitus

    • Fasting blood sugar levels: Normal is <100mg/dL, Prediabetes 100-125mg/dL, and Diabetes ≥126mg/dL.
    • Glycated hemoglobin (HbA1C): Normal is <5.6%, prediabetes 5.7%-6.4%, and Diabetes ≥6.5%.
    • Random/Postprandial blood sugar (Postprandial): ≥200mg/dL.
    • Symptoms such as increased fluid intake, urination frequency, and unexplained weight loss, together with elevated values, support the diagnosis.

    Diagnostic Criteria for Gestational Diabetes

    • Diagnose gestational diabetes when one of these criteria is met:
      • Fasting plasma glucose: 92-125 mg/dL, or
      • 1-hour post-load plasma glucose: ≥ 180 mg/dL, or
      • 2-hour post-load plasma glucose: 153-198 mg/dL.

    Clinical Criteria for Initial Management of Diabetes (Type 1)

    • Disease onset prior to 30 years old.
    • Lean body habitus.
    • Insulin requirement as initial therapy.
    • Propensity to develop ketoacidosis.
    • Increased risk for other autoimmune disorders.

    Clinical Criteria for Initial Management of Diabetes (Type 2)

    • Disease onset after 30 years old.
    • Commonly overweight or obese.
    • Often begins without insulin therapy.
    • Potential insulin resistance.
    • Potential co-occurring conditions including hypertension, cardiovascular disease, dyslipidaemia, or PCOS.

    Comprehensive Medical Evaluation of Diabetes

    • Confirm the diagnosis and classify the specific type of diabetes.
    • Identify and assess any existing diabetes complications and comorbid conditions.
    • Establish a patient's previous treatment history and risk exposures.
    • Engage patients in establishing a care management plan.
    • Develop a continued diabetes management plan.

    Management of DKA

    • Urgent initial treatment involves starting IV fluids (Normal Saline).
    • Urine ketones need to be assessed and acted upon throughout the treatment course.
    • Insulin is given and dosage is increased as needed to monitor resolution.
    • Electrolyte (potassium) balance must be carefully managed.

    Management of HHS

    • Similar to DKA, IV fluids and insulin are crucial, and treatment is based on vital signs, free water deficit, and urine output.

    Hypoglycemia Management

    • Hypoglycemia, or abnormally low blood glucose, is a prevalent concern, particularly in patients with DM, particularly those taking sulfonylureas or insulin.
    • Symptoms include headache, hunger, irritability, anxiety, paraesthesias, and palpitations.
    • Signs can also include sweating, trembling, difficulty speaking, confusion, ataxia, stupor, pallor, seizures, and coma.
    • Treatment involves providing glucose (oral) or IV glucose.

    Management of Chronic Complications (Diabetic Nephropathy)

    • Urine protein analysis is essential to detect early signs of diabetic nephropathy at diagnosis and annually.
    • Treatment may involve referring to a specialist when abnormal findings necessitate further investigation.
    • Medication such as enalapril may be instrumental in managing diabetic nephropathy.

    Diabetic Neuropathy

    • Establish a neuropathy screening program.
    • An abnormal result warrants appropriate referral.
    • Management and care, including foot care, may be necessary in response to abnormal findings.

    Reasons for Referral to Higher Level

    • Recurrent hypoglycemia
    • Hypoglycemic unawareness
    • Erectile dysfunction
    • Need for insulin management at health facility
    • Abnormal renal/retinal results
    • Complaints of neuropathy
    • Pregnancy complications
    • Persistent/worsening DKA

    Diabetes Treatment Goals

    • Setting appropriate blood glucose targets for management.
    • Providing diabetes-related lifestyle modifications.
    • Providing diabetes-related diet and exercise counseling.
    • Monitoring treatment and outcomes to ensure management effectiveness.
    • Using and managing diabetes medications appropriately.

    Management of Type 2 DM with Oral Agents

    • Metformin is often the initial treatment option, as it does not cause weight gain or hypoglycemia.
    • A second-generation sulfonylurea, such as glibenclamide or glimepiride, might be the first-line treatment option when metformin is ineffective.
    • Insulin therapy may be considered in cases where oral agents are not effectively managing blood glucose.

    Management of Type 2 DM with Insulin

    • Steps needed to initiate insulin treatment for patients with Type 2 Diabetes, including dosage adjustments, and monitoring for hypoglycemia.

    Type 1 DM Management Protocol

    • Initiate patients on subcutaneous insulin injections as soon as possible.
    • Education, including details on insulin, hypoglycemia, and chronic complications, dietary considerations and exercise, are essential components of management.

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    DM Presentation PDF

    Description

    This quiz covers essential characteristics and complications of Type 1 and Type 2 Diabetes Mellitus. Explore the etiology, progression, and risk factors associated with diabetes, as well as its long-term effects on health. Test your understanding of the fundamental aspects of diabetes management and prevention.

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