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Questions and Answers
What is a primary characteristic of Type 1 Diabetes Mellitus (DM)?
What is a primary characteristic of Type 1 Diabetes Mellitus (DM)?
Which of the following best describes Type 2 Diabetes Mellitus (DM)?
Which of the following best describes Type 2 Diabetes Mellitus (DM)?
What is a shared characteristic between Type 1 and Type 2 diabetes regarding their progression?
What is a shared characteristic between Type 1 and Type 2 diabetes regarding their progression?
Which of the following is NOT explicitly listed as an etiology of diabetes mellitus?
Which of the following is NOT explicitly listed as an etiology of diabetes mellitus?
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What is the primary result of the defects in insulin action or secretion that are characteristic of Type 2 diabetes?
What is the primary result of the defects in insulin action or secretion that are characteristic of Type 2 diabetes?
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What is the primary characteristic of diabetes mellitus?
What is the primary characteristic of diabetes mellitus?
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Which of the following is NOT a long-term specific complication of diabetes mellitus?
Which of the following is NOT a long-term specific complication of diabetes mellitus?
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Besides the specific complications, what other diseases are people with diabetes at increased risk for?
Besides the specific complications, what other diseases are people with diabetes at increased risk for?
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What are the major factors contributing to hyperglycemia in diabetes mellitus?
What are the major factors contributing to hyperglycemia in diabetes mellitus?
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In the United States, diabetes mellitus is the leading cause of all the following EXCEPT:
In the United States, diabetes mellitus is the leading cause of all the following EXCEPT:
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Which of the following is a major cause of morbidity and mortality in people with diabetes?
Which of the following is a major cause of morbidity and mortality in people with diabetes?
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According to the classification of diabetes mellitus, how many broad categories are there?
According to the classification of diabetes mellitus, how many broad categories are there?
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What is the fundamental basis for classifying diabetes mellitus?
What is the fundamental basis for classifying diabetes mellitus?
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Which of the following is NOT a typical symptom associated with Maturity-Onset Diabetes of the Young (MODY)?
Which of the following is NOT a typical symptom associated with Maturity-Onset Diabetes of the Young (MODY)?
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According to the provided information, at what age should asymptomatic adults be screened for diabetes every three years?
According to the provided information, at what age should asymptomatic adults be screened for diabetes every three years?
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Which of the following is NOT an indication for screening for diabetes in asymptomatic adults?
Which of the following is NOT an indication for screening for diabetes in asymptomatic adults?
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What is the diagnostic criterion for gestational diabetes based on a 2-hour post-load plasma glucose test?
What is the diagnostic criterion for gestational diabetes based on a 2-hour post-load plasma glucose test?
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A patient presents with intense thirst, frequent urination, and visual blurring. Which of the following would NOT fall under the signs of diabetes?
A patient presents with intense thirst, frequent urination, and visual blurring. Which of the following would NOT fall under the signs of diabetes?
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Which of the following is a typical characteristic of Type 1 Diabetes Mellitus at the initial presentation?
Which of the following is a typical characteristic of Type 1 Diabetes Mellitus at the initial presentation?
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An individual with which of the following triglyceride levels should be screened for diabetes?
An individual with which of the following triglyceride levels should be screened for diabetes?
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What fasting plasma glucose level is considered diagnostic for gestational diabetes?
What fasting plasma glucose level is considered diagnostic for gestational diabetes?
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What is the recommended initial treatment for patients with Type 2 diabetes who do not achieve desired glycemic control with diet and exercise?
What is the recommended initial treatment for patients with Type 2 diabetes who do not achieve desired glycemic control with diet and exercise?
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Which of the following dietary changes should be avoided in managing Type 2 diabetes?
Which of the following dietary changes should be avoided in managing Type 2 diabetes?
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What is the maximum recommended alcohol intake for women per day?
What is the maximum recommended alcohol intake for women per day?
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What should be the initial dose of Metformin when starting treatment?
What should be the initial dose of Metformin when starting treatment?
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Which medication may cause weight gain and hypoglycemia when used as initial treatment for Type 2 diabetes?
Which medication may cause weight gain and hypoglycemia when used as initial treatment for Type 2 diabetes?
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Under what condition should insulin therapy be considered for a patient with Type 2 diabetes?
Under what condition should insulin therapy be considered for a patient with Type 2 diabetes?
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What is advised if a patient's BMI is greater than 25 kg/m2?
What is advised if a patient's BMI is greater than 25 kg/m2?
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What dietary recommendation is suggested for people managing Type 2 diabetes?
What dietary recommendation is suggested for people managing Type 2 diabetes?
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What is the initial management step for patients with Type 1 Diabetes Mellitus (DM)?
What is the initial management step for patients with Type 1 Diabetes Mellitus (DM)?
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What is the recommended insulin adjustment when a Type 2 DM patient requires a bedtime insulin dose greater than 20 units?
What is the recommended insulin adjustment when a Type 2 DM patient requires a bedtime insulin dose greater than 20 units?
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How frequently should patients with well-managed blood glucose levels be followed up?
How frequently should patients with well-managed blood glucose levels be followed up?
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What should be monitored in Type 2 DM patients who are not on insulin?
What should be monitored in Type 2 DM patients who are not on insulin?
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What type of education is essential for patients with Type 1 DM?
What type of education is essential for patients with Type 1 DM?
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When should fasting and postprandial blood glucose measurements be taken for patients on insulin?
When should fasting and postprandial blood glucose measurements be taken for patients on insulin?
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What should be the frequency of HbA1c testing for those who have it available?
What should be the frequency of HbA1c testing for those who have it available?
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What is a key indicator of the need for more frequent follow-up in diabetes management?
What is a key indicator of the need for more frequent follow-up in diabetes management?
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Which of the following is a feature of Diabetic Ketoacidosis (DKA)?
Which of the following is a feature of Diabetic Ketoacidosis (DKA)?
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What is the first step in the initial management of DKA?
What is the first step in the initial management of DKA?
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Identify the plasma glucose level that defines hypoglycemia.
Identify the plasma glucose level that defines hypoglycemia.
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Which symptom is commonly associated with hypoglycemia?
Which symptom is commonly associated with hypoglycemia?
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What should be administered when blood glucose is below 70 mg/dL?
What should be administered when blood glucose is below 70 mg/dL?
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Which of the following management steps is recommended for a hemodynamically unstable patient with DKA?
Which of the following management steps is recommended for a hemodynamically unstable patient with DKA?
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What does Ketonuria >1+ indicate in relation to DKA?
What does Ketonuria >1+ indicate in relation to DKA?
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What complication is often associated with the treatment of diabetic patients using insulin or sulfonylurea?
What complication is often associated with the treatment of diabetic patients using insulin or sulfonylurea?
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Flashcards
What is Diabetes Mellitus?
What is Diabetes Mellitus?
Diabetes mellitus is a group of metabolic disorders characterized by high blood sugar levels, either due to the body not producing enough insulin, the body not using insulin properly, or both.
Diabetes Epidemiology
Diabetes Epidemiology
Diabetes is a growing global concern, affecting millions worldwide. It's a complex disease with a variety of complications, ranging from vision loss to kidney failure.
Type 1 Diabetes
Type 1 Diabetes
Type 1 diabetes occurs when the body's immune system attacks and destroys the insulin-producing cells in the pancreas.
Type 2 Diabetes
Type 2 Diabetes
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Gestational Diabetes
Gestational Diabetes
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Diabetes Complications
Diabetes Complications
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Diabetes Management Strategies
Diabetes Management Strategies
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Preventing Diabetes
Preventing Diabetes
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Prediabetes
Prediabetes
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Hyperglycemia
Hyperglycemia
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Other Types of Diabetes
Other Types of Diabetes
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What is Maturity-onset diabetes of the young (MODY)?
What is Maturity-onset diabetes of the young (MODY)?
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What is monogenic diabetes?
What is monogenic diabetes?
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What is prediabetes?
What is prediabetes?
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What is gestational diabetes?
What is gestational diabetes?
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What is Type 1 diabetes?
What is Type 1 diabetes?
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What is Type 2 diabetes?
What is Type 2 diabetes?
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What is a key symptom of early diabetes?
What is a key symptom of early diabetes?
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Who should be screened for diabetes?
Who should be screened for diabetes?
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Healthy Dietary Advice for Diabetes
Healthy Dietary Advice for Diabetes
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What is Metformin?
What is Metformin?
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What are Sulfonylureas?
What are Sulfonylureas?
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What is HbA1c?
What is HbA1c?
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What is Intensification of Treatment?
What is Intensification of Treatment?
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What is Hypoglycemia?
What is Hypoglycemia?
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What is Overweight?
What is Overweight?
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Importance of lifestyle changes in diabetes
Importance of lifestyle changes in diabetes
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Insulin initiation in type 2 diabetes
Insulin initiation in type 2 diabetes
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Insulin therapy for type 1 diabetes
Insulin therapy for type 1 diabetes
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Diabetes education for patients
Diabetes education for patients
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Monitoring diabetes patients
Monitoring diabetes patients
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Self-monitoring of blood glucose (SMBG)
Self-monitoring of blood glucose (SMBG)
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SMBG in type 2 diabetes without insulin
SMBG in type 2 diabetes without insulin
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Fasting and postprandial blood sugar monitoring
Fasting and postprandial blood sugar monitoring
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Diabetic Ketoacidosis (DKA)
Diabetic Ketoacidosis (DKA)
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Hyperosmolar Hyperglycemic State (HHS)
Hyperosmolar Hyperglycemic State (HHS)
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Polyuria
Polyuria
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Polydipsia
Polydipsia
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Fruity odor
Fruity odor
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Symptoms of Hypoglycemia
Symptoms of Hypoglycemia
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Hypoglycemia Management
Hypoglycemia Management
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Study Notes
Diabetes Mellitus
- Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia in the absence of treatment.
- The pathophysiology is heterogeneous, involving defects in insulin secretion, insulin action, or both.
- Long-term complications include retinopathy, nephropathy, and neuropathy.
- People with diabetes have an increased risk of cardiac, peripheral arterial, and cerebrovascular diseases, as well as cataracts, erectile dysfunction, and non-alcoholic fatty liver disease.
- The risk of infectious diseases such as tuberculosis is also increased.
- Contributing factors to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production.
- The metabolic dysregulation in DM causes secondary pathophysiologic changes in multiple organ systems, placing a significant burden on individuals and the healthcare system.
- In the US, diabetes is the leading cause of end-stage renal disease (ESRD).
- Non-traumatic lower extremity amputations and adult blindness are also associated risks.
- Diabetes is a leading cause of mortality, frequently listed as the seventh leading cause of death in the US.
Classification of DM
- Diabetes is classified based on the pathogenic process leading to hyperglycemia.
- Two broad categories are type 1 and type 2 DM.
- Other forms of diabetes exist, showing increasing recognition and better understanding of molecular pathogenesis.
- These atypical forms may share features of both type 1 and type 2 DM but are distinct from monogenic forms.
- Type 1 DM typically develops due to autoimmunity against insulin-producing beta cells, resulting in insulin deficiency.
- Type 2 DM is a heterogeneous group of disorders characterized by variable degrees of insulin resistance, impaired insulin secretion, and increased hepatic glucose production. This commonly links to defects in insulin action and/or secretion.
Gestational DM
- Gestational diabetes mellitus (GDM) is glucose intolerance developing during the second or third trimester of pregnancy.
- Insulin resistance during pregnancy is linked to increased insulin demands, potentially leading to impaired glucose tolerance (IGT) or diabetes.
- The American Diabetes Association (ADA) classifies diabetes diagnosed in the first trimester as preexisting pregestational diabetes, rather than GDM.
- Most women with GDM revert to normal glucose tolerance postpartum but have a substantial risk of developing diabetes within 10-20 years.
- Children born to mothers with GDM display an increased risk of developing metabolic syndrome and type 2 DM.
Atypical Diabetes
- Some diabetes forms exhibit features of both type 1 and type 2, but are distinct from monogenic forms.
- Prepubertal onset of type 2 diabetes and ketosis-prone diabetes in lean individuals are examples.
- A majority of atypical diabetes cases are African American or Asian.
- Research is actively pursuing mechanisms for atypical forms of diabetes.
Epidemiology and Global Considerations
- The global prevalence of DM has risen significantly. In 2019, the number of cases worldwide was estimated at 463 million with predictions of 642 million by 2040.
- The type 2 prevalence rate is increasing rapidly, likely due to dietary changes, increasing obesity, reduced activity, and population aging.
- The rate of type 1 DM is also increasing, although the reasons are less understood, but it is frequently diagnosed in younger individuals.
- Countries in Scandinavia, followed by Sardinia and Portugal, show the highest rates of type 1 DM, whereas the lowest rates are found in the Pacific Rim.
- Northern Europe and the United States show intermediate rates.
- The prevalence of both total diabetes and type 2 diabetes/IGT are highest in certain Pacific islands and the Middle East, and intermediate in countries like India and the United States.
- Onset of type 2 DM tends to occur at a younger age in ethnic groups other than non-Hispanic white individuals, particularly in Asia.
Common Symptoms of DM
- Thirst
- Frequent urination
- Blurring of vision
- Fatigue
Signs of Diabetes
- Unintentional weight loss
- Signs of acute metabolic deterioration (severe dehydration, respiratory distress)
- Vomiting
- Altered consciousness level
- Clinical signs of chronic complications (acute coronary disease, stroke, kidney disease, vision loss, diabetic foot)
Diagnostic Criteria for Diabetes Mellitus
- Fasting blood sugar levels: Normal is <100mg/dL, Prediabetes 100-125mg/dL, and Diabetes ≥126mg/dL.
- Glycated hemoglobin (HbA1C): Normal is <5.6%, prediabetes 5.7%-6.4%, and Diabetes ≥6.5%.
- Random/Postprandial blood sugar (Postprandial): ≥200mg/dL.
- Symptoms such as increased fluid intake, urination frequency, and unexplained weight loss, together with elevated values, support the diagnosis.
Diagnostic Criteria for Gestational Diabetes
- Diagnose gestational diabetes when one of these criteria is met:
- Fasting plasma glucose: 92-125 mg/dL, or
- 1-hour post-load plasma glucose: ≥ 180 mg/dL, or
- 2-hour post-load plasma glucose: 153-198 mg/dL.
Clinical Criteria for Initial Management of Diabetes (Type 1)
- Disease onset prior to 30 years old.
- Lean body habitus.
- Insulin requirement as initial therapy.
- Propensity to develop ketoacidosis.
- Increased risk for other autoimmune disorders.
Clinical Criteria for Initial Management of Diabetes (Type 2)
- Disease onset after 30 years old.
- Commonly overweight or obese.
- Often begins without insulin therapy.
- Potential insulin resistance.
- Potential co-occurring conditions including hypertension, cardiovascular disease, dyslipidaemia, or PCOS.
Comprehensive Medical Evaluation of Diabetes
- Confirm the diagnosis and classify the specific type of diabetes.
- Identify and assess any existing diabetes complications and comorbid conditions.
- Establish a patient's previous treatment history and risk exposures.
- Engage patients in establishing a care management plan.
- Develop a continued diabetes management plan.
Management of DKA
- Urgent initial treatment involves starting IV fluids (Normal Saline).
- Urine ketones need to be assessed and acted upon throughout the treatment course.
- Insulin is given and dosage is increased as needed to monitor resolution.
- Electrolyte (potassium) balance must be carefully managed.
Management of HHS
- Similar to DKA, IV fluids and insulin are crucial, and treatment is based on vital signs, free water deficit, and urine output.
Hypoglycemia Management
- Hypoglycemia, or abnormally low blood glucose, is a prevalent concern, particularly in patients with DM, particularly those taking sulfonylureas or insulin.
- Symptoms include headache, hunger, irritability, anxiety, paraesthesias, and palpitations.
- Signs can also include sweating, trembling, difficulty speaking, confusion, ataxia, stupor, pallor, seizures, and coma.
- Treatment involves providing glucose (oral) or IV glucose.
Management of Chronic Complications (Diabetic Nephropathy)
- Urine protein analysis is essential to detect early signs of diabetic nephropathy at diagnosis and annually.
- Treatment may involve referring to a specialist when abnormal findings necessitate further investigation.
- Medication such as enalapril may be instrumental in managing diabetic nephropathy.
Diabetic Neuropathy
- Establish a neuropathy screening program.
- An abnormal result warrants appropriate referral.
- Management and care, including foot care, may be necessary in response to abnormal findings.
Reasons for Referral to Higher Level
- Recurrent hypoglycemia
- Hypoglycemic unawareness
- Erectile dysfunction
- Need for insulin management at health facility
- Abnormal renal/retinal results
- Complaints of neuropathy
- Pregnancy complications
- Persistent/worsening DKA
Diabetes Treatment Goals
- Setting appropriate blood glucose targets for management.
- Providing diabetes-related lifestyle modifications.
- Providing diabetes-related diet and exercise counseling.
- Monitoring treatment and outcomes to ensure management effectiveness.
- Using and managing diabetes medications appropriately.
Management of Type 2 DM with Oral Agents
- Metformin is often the initial treatment option, as it does not cause weight gain or hypoglycemia.
- A second-generation sulfonylurea, such as glibenclamide or glimepiride, might be the first-line treatment option when metformin is ineffective.
- Insulin therapy may be considered in cases where oral agents are not effectively managing blood glucose.
Management of Type 2 DM with Insulin
- Steps needed to initiate insulin treatment for patients with Type 2 Diabetes, including dosage adjustments, and monitoring for hypoglycemia.
Type 1 DM Management Protocol
- Initiate patients on subcutaneous insulin injections as soon as possible.
- Education, including details on insulin, hypoglycemia, and chronic complications, dietary considerations and exercise, are essential components of management.
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Description
This quiz covers essential characteristics and complications of Type 1 and Type 2 Diabetes Mellitus. Explore the etiology, progression, and risk factors associated with diabetes, as well as its long-term effects on health. Test your understanding of the fundamental aspects of diabetes management and prevention.