Podcast Beta
Questions and Answers
What is the primary mechanism of action of metformin in treating type 2 diabetes?
Which of the following patients is not a suitable candidate for metformin therapy?
Which of the following adverse effects is most serious but rare in patients taking metformin?
What is the recommended administration schedule for metformin?
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In which situation should metformin be withdrawn prior to a medical procedure?
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Study Notes
Mechanism of Action
- Reduces hepatic glucose production through inhibition of gluconeogenesis.
- Increases glucose uptake and oxidation in skeletal muscle via activation of AMP kinase.
- Decreases insulin resistance, enhancing the overall efficacy of insulin.
Pharmacokinetics
- Administered orally, typically 2-3 times daily.
- Sustained-release formulations are available for improved dosing convenience.
Adverse Effects
- Commonly causes gastrointestinal disturbances.
- Lactic acidosis is a serious but rare adverse event; vigilance is necessary.
- Contraindicated in patients with renal, hepatic, hypoxic respiratory, or cardiac diseases.
- Should be withheld prior to iodine-containing X-ray contrast media procedures to prevent complications.
Clinical Use
- First-line treatment for overweight or obese individuals with type 2 diabetes.
- Compatible with all other antidiabetic medications, including insulin, enhancing treatment flexibility.
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Description
This quiz covers the mechanism of action, pharmacokinetics, adverse effects, and clinical use of diabetes medications. It focuses particularly on treatments for type 2 diabetes, including their benefits and considerations for patient care. Test your knowledge on how these medications function and their impact on patient health.
