Diabetes Management Quiz
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Questions and Answers

What is the primary function of insulin in the body?

  • To break down stored fat for energy
  • To increase blood glucose levels
  • To facilitate glucose transport into cells (correct)
  • To synthesize glucagon in the pancreas

What are potential risk factors for developing Diabetes Mellitus?

  • Genetic predisposition only
  • Viral infections and lifestyle choices (correct)
  • Age and gender exclusively
  • None of the above

Which type of diabetes accounts for 10% of diagnosed cases?

  • Gestational Diabetes
  • Type 1 Diabetes Mellitus (correct)
  • Type 2 Diabetes Mellitus
  • Secondary Diabetes

What happens to insulin secretion after a meal?

<p>Insulin secretion increases (D)</p> Signup and view all the answers

Which statement about glucagon is true?

<p>Glucagon breaks down stored fuels during fasting (B)</p> Signup and view all the answers

What is the recommended frequency and duration of exercise for individuals managing diabetes?

<p>30 minutes five times a week (D)</p> Signup and view all the answers

Which of the following is a potential risk associated with alcohol consumption in patients taking insulin or oral hypoglycemic agents?

<p>Severe hypoglycemia (B)</p> Signup and view all the answers

What blood glucose level is considered as hypoglycemia?

<p>Less than 4 mmol/L (B)</p> Signup and view all the answers

What can lead to hypoglycemia in individuals managing diabetes?

<p>Mismatched timing between food intake and insulin action (B)</p> Signup and view all the answers

What is a common manifestation of untreated hypoglycemia?

<p>Irritability and confusion (B)</p> Signup and view all the answers

What is a common risk factor for nontraumatic lower limb amputations in individuals with diabetes mellitus (DM)?

<p>Sensory neuropathy (C)</p> Signup and view all the answers

Which of the following is NOT included in the chronic complications of diabetes mellitus?

<p>Increased bone density (A)</p> Signup and view all the answers

How frequently is screening recommended for individuals with diabetes to assess foot health?

<p>Annually or more frequently (B)</p> Signup and view all the answers

Which action is NOT advised for foot care in individuals with diabetes?

<p>Cut and file nails unevenly (A)</p> Signup and view all the answers

What damaging substance accumulates in blood vessels due to glucose metabolism?

<p>Sorbitol (C)</p> Signup and view all the answers

What is a primary reason insulin is considered a high-risk medication?

<p>May require a co-signature (A)</p> Signup and view all the answers

Which of the following adverse events is associated with insulin administration?

<p>Hypoglycemia (C)</p> Signup and view all the answers

How do oral hypoglycemic agents (OHAs) primarily function?

<p>By enhancing insulin sensitivity (B)</p> Signup and view all the answers

What is a recommended dietary approach for managing blood sugar levels?

<p>Practice carb counting (D)</p> Signup and view all the answers

What must be present for oral hypoglycemic agents (OHAs) to be effective?

<p>Some level of circulating insulin (C)</p> Signup and view all the answers

Which of the following nutrients should be decreased in a balanced diet for diabetes management?

<p>Simple sugars (D)</p> Signup and view all the answers

What does a Hemoglobin A1C level of 6.5% or higher indicate?

<p>Glucose control over the past 90-120 days (C)</p> Signup and view all the answers

What should be assessed when a patient uses their own insulin pens and glucometers?

<p>Site assessment and rotation (D)</p> Signup and view all the answers

What is the role of fasting plasma glucose testing?

<p>Shows blood glucose levels after a period of fasting (C)</p> Signup and view all the answers

What is a safety recommendation regarding exercise for patients with diabetes?

<p>Listen to your body (D)</p> Signup and view all the answers

Which statement about insulin is accurate?

<p>Some Type 2 diabetics may require exogenous insulin (D)</p> Signup and view all the answers

What distinguishes rapid-acting insulin from intermediate-acting insulin?

<p>Rapid-acting insulin is taken before meals, while intermediate-acting lasts longer. (C)</p> Signup and view all the answers

What is the rationale for drawing up clear insulin before cloudy insulin?

<p>To prevent the cloudy solution from clouding the clear one (C)</p> Signup and view all the answers

What level of glucose indicates a two-hour Oral Glucose Tolerance Test (OGTT) result?

<p>Greater than or equal to 11.1 (D)</p> Signup and view all the answers

Which lifestyle change is often necessary alongside medication for diabetes management?

<p>Structured exercise regimen (D)</p> Signup and view all the answers

In relation to insulin types, what is generally stated about long-acting insulin?

<p>It provides a steady level of insulin without a peak. (C)</p> Signup and view all the answers

What is typically the first step in diagnosing hypoglycemia when a glucometer is unavailable?

<p>Suspect hypoglycemia based on symptoms (D)</p> Signup and view all the answers

Which complication is characterized by the breakdown of fats due to an absence of insulin?

<p>Diabetic Ketoacidosis (C)</p> Signup and view all the answers

What is a common clinical manifestation of Diabetic Ketoacidosis?

<p>Kussmaul’s respirations (D)</p> Signup and view all the answers

In Hyperosmolar Hyperglycemic Syndrome, which symptom is often observed in earlier stages?

<p>Neurological manifestations (D)</p> Signup and view all the answers

What blood glucose level is typically indicative of Hyperosmolar Hyperglycemic Syndrome?

<blockquote> <p>34 mmol/L (B)</p> </blockquote> Signup and view all the answers

Which of the following is NOT a precipitating factor for Diabetic Ketoacidosis?

<p>Smoking (A)</p> Signup and view all the answers

What is a common consequence of inadequate fluid intake in Hyperosmolar Hyperglycemic Syndrome?

<p>Increasing mental depression (C)</p> Signup and view all the answers

What distinguishes Hyperosmolar Hyperglycemic Syndrome from Diabetic Ketoacidosis?

<p>Absence of ketone bodies (C)</p> Signup and view all the answers

What underlying condition can contribute to leg ulcers and gangrene in individuals with diabetes mellitus?

<p>Poor circulation due to peripheral vascular disease (PVD) (B)</p> Signup and view all the answers

Which of the following chronic complications is commonly associated with oxidative stress in diabetes?

<p>Retinopathy (C)</p> Signup and view all the answers

What is a recommended practice for individuals with diabetes to maintain foot health?

<p>Use mild soaps and dry feet thoroughly after washing (D)</p> Signup and view all the answers

What type of damage can be caused by the accumulation of sorbitol in blood vessels?

<p>Neuropathy and retinopathy (C)</p> Signup and view all the answers

Which of the following is an essential recommendation for foot care in diabetic patients?

<p>Examine feet daily for signs of injury (B)</p> Signup and view all the answers

What should individuals who take insulin do to prevent hypoglycemia during exercise?

<p>Monitor blood sugar levels before, during, and after activity (D)</p> Signup and view all the answers

What is a significant risk associated with alcohol consumption for individuals taking insulin or oral hypoglycemic agents?

<p>Severe hypoglycemia due to inhibited glucose production (B)</p> Signup and view all the answers

Which of the following can lead to hypoglycemia in individuals under insulin therapy?

<p>Exercising at peak insulin action without food intake (A)</p> Signup and view all the answers

What is a common manifestation of hypoglycemia if left untreated?

<p>Irritability and confusion (A)</p> Signup and view all the answers

What strategy can help reduce the risk of hypoglycemia when consuming alcohol?

<p>Limiting consumption to 1 to 2 drinks per day (D)</p> Signup and view all the answers

What is a potential adverse event associated with insulin administration?

<p>Somogi Effect (B)</p> Signup and view all the answers

Which of the following actions is important for the assessment of a patient using their own insulin pens?

<p>Assess the injection site and rotate within the site (C)</p> Signup and view all the answers

What must be ensured for oral hypoglycemic agents (OHAs) to be effective?

<p>Some level of circulating insulin (C)</p> Signup and view all the answers

Which component is crucial in nutritional therapy for diabetes management?

<p>Reducing total fat consumption (A)</p> Signup and view all the answers

What is a characteristic of the Dawn Phenomenon in diabetes management?

<p>Rising blood glucose levels in the early morning (D)</p> Signup and view all the answers

Which dietary approach is commonly used to manage blood sugar levels?

<p>Glycemic Index Diet (A)</p> Signup and view all the answers

What should be assessed to ensure the safety of diabetes management during exercise?

<p>Medical history and readiness for exercise (C)</p> Signup and view all the answers

What is one of the roles of oral hypoglycemic agents (OHAs) in diabetes treatment?

<p>They enhance insulin sensitivity at the cellular level. (C)</p> Signup and view all the answers

What is a key treatment step for hypoglycemia after correction of glucose levels?

<p>Investigate the cause of hypoglycemia (D)</p> Signup and view all the answers

Which clinical manifestation is NOT typically associated with Diabetic Ketoacidosis?

<p>Increased mental alertness (A)</p> Signup and view all the answers

What is a distinguishing factor of Hyperosmolar Hyperglycemic Syndrome compared to Diabetic Ketoacidosis?

<p>Adequate circulating insulin (B)</p> Signup and view all the answers

Which of the following factors can precipitate Diabetic Ketoacidosis?

<p>Undiagnosed type 1 diabetes (D)</p> Signup and view all the answers

What is the typical blood glucose threshold indicating Hyperosmolar Hyperglycemic Syndrome?

<p>Above 34 mmol/L (A)</p> Signup and view all the answers

Which of the following describes a physiological response to stress in diabetes management?

<p>Decreased insulin sensitivity (A)</p> Signup and view all the answers

Which symptom is commonly observed during dehydration in Diabetic Ketoacidosis?

<p>Diminished skin elasticity (B)</p> Signup and view all the answers

Which of the following clinical manifestations is characteristic of Hyperosmolar Hyperglycemic Syndrome in later stages?

<p>Neurological disturbances (A)</p> Signup and view all the answers

Which hormone primarily opposes the action of insulin in the body?

<p>Epinephrine (B)</p> Signup and view all the answers

What is the typical blood sugar target range for individuals managing diabetes?

<p>4-6/7 (A)</p> Signup and view all the answers

Which of the following has been identified as a significant risk factor for developing Type 2 diabetes?

<p>High levels of cholesterol (B)</p> Signup and view all the answers

Which demographic is considered a high-risk population for Type 2 diabetes?

<p>Indigenous (B)</p> Signup and view all the answers

Which manifestation is least likely associated with Type 2 diabetes in its early stages?

<p>Polyuria (A)</p> Signup and view all the answers

How much weight loss can significantly reduce the risk of Type 2 diabetes?

<p>5-7% (A)</p> Signup and view all the answers

Which condition is often characterized by darkened patches of skin known as acanthosis nigricans?

<p>Prediabetes (D)</p> Signup and view all the answers

What is a common symptom experienced by individuals with prolonged uncontrolled glucose levels?

<p>Visual changes (D)</p> Signup and view all the answers

What is the significance of measuring Hemoglobin A1C levels?

<p>It indicates average glucose control over the last 3-4 months. (A)</p> Signup and view all the answers

Which test result indicates a high fasting plasma glucose level?

<p>7.5 mmol/L (A), 8.0 mmol/L (B)</p> Signup and view all the answers

What characterizes a Random Plasma Glucose test result that suggests diabetes?

<p>A level greater than or equal to 11 mmol/L with classic symptoms. (A)</p> Signup and view all the answers

What is the purpose of a Two-Hour Oral Glucose Tolerance Test (OGTT)?

<p>To evaluate how well the body metabolizes glucose. (D)</p> Signup and view all the answers

Which type of insulin is typically administered 30-45 minutes before a meal?

<p>Regular/short acting insulin. (B)</p> Signup and view all the answers

When preparing a mixture of short/rapid acting insulin and intermediate acting insulin, which should be drawn up first?

<p>Short/rapid acting insulin. (D)</p> Signup and view all the answers

Which of the following is true about the use of insulin in Type 2 diabetes?

<p>Only some individuals with Type 2 diabetes need exogenous insulin. (A)</p> Signup and view all the answers

What characteristic defines long-acting insulin?

<p>It is generally given once daily and has no peak. (B)</p> Signup and view all the answers

Flashcards

What is Diabetes?

Diabetes is a condition where the body either doesn't produce enough insulin or can't use it properly, leading to high blood sugar levels.

What causes Diabetes?

Diabetes can be caused by various factors, including genetics, autoimmune disorders, viral infections, and lifestyle choices like obesity and stress.

What are the complications of Diabetes?

Diabetes can lead to serious complications, both short-term and long-term, affecting various organs like the heart, kidneys, and nerves.

What is insulin's role in the body?

Insulin is a hormone that helps regulate blood sugar levels by allowing glucose to enter cells for energy.

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How does glucagon work?

Glucagon is a hormone that raises blood sugar levels by breaking down stored energy in the body.

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HbA1c Test

A blood test that measures the average blood sugar level over the past 2-3 months by looking at how much glucose is attached to hemoglobin in red blood cells.

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Fasting Plasma Glucose Test

A blood test that measures blood sugar levels after an overnight fast, reflecting how well the body regulates glucose without eating.

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Random Plasma Glucose Test

A blood test that measures blood sugar levels regardless of when someone last ate, reflecting how well the body regulates glucose at any given time.

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Oral Glucose Tolerance Test (OGTT)

A blood test that measures blood sugar levels after drinking a sugary drink, reflecting how well the body can metabolize and regulate glucose after a sugary load.

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Exogenous Insulin

Insulin that is produced outside the body and administered to individuals with diabetes.

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Basal Insulin

Insulin that is given to mimic the body's natural, steady, background production of insulin.

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Bolus Insulin

Insulin that is given to cover the rise in blood sugar after meals, mimicking the body's natural spike in insulin after eating.

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Rapid-Acting Insulin

Insulin that starts working quickly, usually within 15 minutes, and lasts for a short period.

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Insulin and Exercise

People who take insulin or medications that increase insulin levels should monitor blood sugar closely before, during, and after exercise. Blood sugar can be lowered for up to 48 hours after activity. It's recommended to eat before exercising and have fast-acting carbohydrates available for hypoglycemia.

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Alcohol and Diabetes

Alcohol can hinder the body's glucose production, increasing the risk of hypoglycemia for people on insulin or medications that increase insulin production. Consuming alcohol with metformin may lead to lactic acidosis. It is recommended to limit alcohol to 1-2 drinks per day, eat food while drinking, use sugar-free mixers, and stick to dry or light wines.

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Acute Diabetes Complications

A primary acute complication of diabetes is hypoglycemia, which occurs when blood sugar drops below 4 mmol/L.

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Hypoglycemia Causes

Hypoglycemia can happen in people on insulin or oral hypoglycemic agents, primarily due to a mismatch in timing between food intake and the peak action of these medications. Too much insulin, not enough food, or a delay in meal timing can all contribute to low blood sugar.

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Hypoglycemia Symptoms

Hypoglycemia can progress to irritability, difficulty speaking, confusion, loss of consciousness, seizures, coma, and death. Not everyone experiences these symptoms, and hypoglycemic unawareness can occur due to autonomic neuropathy.

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Insulin Administration: High Risk

Insulin administration requires a physician's order, often a mix of sliding scale and scheduled doses. Due to its potential for serious adverse effects, it's considered a high-risk medication and may require a co-signature.

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Insulin Administration: Assessing Patient Supplies

When a patient has their own insulin pens or glucometers, it's important to assess the site of insulin injections for signs of infection or lipodystrophy, a condition that can alter insulin absorption.

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Insulin Administration: Adverse Events

Potential adverse events of insulin administration include hypoglycemia (low blood sugar), Somogyi effect (rebound hyperglycemia after hypoglycemia), and Dawn Phenomenon (naturally occurring rise in blood sugar in the morning).

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Oral Hypoglycemic Agents (OHAs)

OHAs are medications used to manage blood sugar levels in people with type 2 diabetes. They work by increasing insulin production, enhancing insulin sensitivity, reducing glucose production in the liver, and slowing down carbohydrate absorption.

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OHAs: Mechanism of Action

OHAs achieve their effect by various pathways including: increasing insulin production, enhancing insulin sensitivity, reducing glucose production in the liver, slowing down carbohydrate absorption, and allowing certain hormones, like Incretin, to stay in the bloodstream longer.

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Diabetes Nutritional Therapy: Goals

Nutritional therapy for diabetes aims to regulate blood sugar, control serum lipid levels, and manage blood pressure. It often involves carb counting and utilizes a balanced diet.

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Balanced Diet for Diabetes

A balanced diet for diabetes includes reducing total fat (especially saturated fat), increasing fiber, decreasing simple sugars, and consuming small meals throughout the day instead of three large ones.

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Glycemic Index Diet

The glycemic index (GI) diet takes into account how specific carbohydrates affect blood sugar levels. Foods with a higher GI cause a faster and higher rise in blood sugar, requiring more insulin.

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What are some chronic complications of diabetes?

Diabetes can lead to various chronic complications, primarily due to vascular damage, affecting various organs like the eyes, kidneys, and nerves.

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How does diabetes affect the eyes?

Diabetes can cause damage to the small blood vessels in the eyes, leading to retinopathy, a condition that can cause vision loss.

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How does diabetes affect the feet?

People with diabetes are at a much higher risk of developing foot complications, including ulcers, gangrene, and amputation, due to poor blood flow and nerve damage.

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What are some important foot care tips for people with diabetes?

People with diabetes should examine their feet daily, care for their nails, wear proper fitting shoes, test bath water temperature, and dry their feet thoroughly after washing.

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Why is annual foot screening recommended for people with diabetes?

Annual foot screenings are recommended for people with diabetes to identify early signs of foot complications and prevent serious problems.

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Hypoglycemia: What is it?

A condition where blood sugar levels drop too low, often caused by excess insulin, insufficient food intake, or intense physical activity.

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Hypoglycemia: How to treat?

Treat quickly with glucose, like sugar, juice, or candy to raise blood sugar. Monitor blood sugar levels and investigate the cause.

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Diabetic Ketoacidosis (DKA): What is it?

A serious complication of diabetes where the body starts breaking down fat for energy, leading to high blood sugar, ketones in the blood, and acidosis.

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DKA: What are the symptoms?

DKA symptoms include: frequent urination, thirst, fatigue, nausea, vomiting, fruity breath, rapid breathing, and dehydration.

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Hyperosmolar Hyperglycemic Syndrome (HHS): What is it?

A serious condition marked by extremely high blood sugar, dehydration, and mental confusion, but without the ketones seen in DKA. Occurs usually in people with type 2 diabetes.

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HHS: What's the difference from DKA?

HHS shares high blood sugar and dehydration with DKA, but unlike DKA, it doesn't involve ketones, and often occurs in people with type 2 diabetes.

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HHS: What causes it?

HHS is often triggered by insufficient fluid intake, increasing mental depression, and excessive urination, often in people with poorly controlled type 2 diabetes.

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HHS: What are the lab values?

Blood glucose levels in HHS are extreme (>34 mmol/L), serum osmolality is increased, and there are little to no ketones present.

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What are the risks of alcohol consumption for people with diabetes who take insulin or OHAs?

Drinking alcohol can significantly increase the risk of severe hypoglycemia in individuals taking insulin or oral hypoglycemic agents (OHAs) that increase insulin production. This is because alcohol inhibits glucose production in the liver, leading to lower blood sugar levels.

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How can you reduce the risk of hypoglycemia when drinking alcohol with diabetes?

To minimize the risk of hypoglycemia, individuals with diabetes should limit alcohol intake to no more than 1-2 drinks per day, eat food while drinking, use sugar-free mixers, and choose dry or light wines. Consistent communication with healthcare providers is essential.

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What is hypoglycemia and what causes it?

Hypoglycemia occurs when blood sugar levels drop below 4 mmol/L. This is usually caused by a mismatch between insulin or OHA dosage and food intake, leading to too much insulin in proportion to glucose in the blood.

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What are the clinical manifestations of untreated hypoglycemia?

Untreated hypoglycemia can progress to irritability, difficulty speaking, confusion, loss of consciousness, seizures, coma, and even death. This is because the brain requires a constant supply of glucose to function properly.

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What is hypoglycemic unawareness and what causes it?

Hypoglycemic unawareness is a condition where individuals with diabetes do not experience the usual warning signs of low blood sugar. This is often associated with autonomic neuropathy, a complication of diabetes affecting the nerves.

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Two-Hour Oral Glucose Tolerance Test (OGTT)

Measures how well the body metabolizes glucose after a sugary drink, highlighting insulin production and response.

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Why Draw Up Clear Insulin Before Cloudy?

Clear insulin (short/rapid acting) should be drawn up before cloudy insulin (intermediate acting) to prevent mixing and altering the insulin's action.

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What is insulin administration considered?

Insulin administration is classified as a high-risk medication due to the potential for severe complications like hypoglycemia.

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What are some adverse events of insulin administration?

Common adverse events associated with insulin administration include hypoglycemia (low blood sugar), Somogyi effect (rebound hyperglycemia after hypoglycemia), and Dawn Phenomenon (natural rise in blood sugar in the morning).

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What are the goals of nutritional therapy for diabetes?

Nutritional therapy aims to regulate blood sugar levels, control lipids in the blood (serum lipid), and manage blood pressure.

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What is the glycemic index diet?

The glycemic index (GI) diet considers how different carbohydrates affect blood sugar levels. Foods with a higher GI cause a faster and higher rise in blood sugar, requiring more insulin.

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What is the Somogyi effect?

The Somogyi effect is a rebound hyperglycemia that occurs after a period of hypoglycemia (low blood sugar).

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What is the Dawn Phenomenon?

The Dawn Phenomenon is a naturally occurring rise in blood sugar levels in the morning, often seen in people with diabetes.

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Why is pre-exercise assessment important for people with diabetes?

Pre-exercise assessment helps to assess the individual's risk of hypoglycemia during exercise and develop a safe exercise plan.

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What should you do if you experience symptoms of hypoglycemia?

Treat hypoglycemia promptly with fast-acting carbohydrates like glucose tablets, sugar, juice, or candy. Monitor blood sugar levels and investigate the cause of the low blood sugar episode.

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Diabetes and Foot Complications

People with diabetes are 20 times more likely to be hospitalized for non-traumatic leg amputations due to factors like poor blood flow, clotting issues, weakened immunity, and nerve damage.

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Foot Care Tips for Diabetes

You should check your feet daily for wounds, cut nails evenly, use mild soap and dry thoroughly after washing, wear properly fitting shoes, and test bath water before stepping in.

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What is Diabetic Retinopathy?

Damage to the small blood vessels in the eyes caused by diabetes, leading to vision loss.

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Sorbitol's Impact on Nerves

A byproduct of glucose metabolism, sorbitol accumulates in blood vessels, particularly affecting nerve cells.

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What is Oxidative Stress in Diabetes?

Excessive free radicals damage the retina, leading to diabetic retinopathy.

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Hypoglycemia: Treatment

Treat quickly with glucose, like sugar, juice, or candy, to raise your blood sugar levels. Monitor blood sugar and find the cause.

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Diabetic Ketoacidosis (DKA)

A serious complication of diabetes where your body starts breaking down fat for energy, leading to high blood sugar, ketones in your blood, and acidosis.

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DKA: Symptoms

Symptoms include frequent urination, thirst, fatigue, nausea, vomiting, fruity breath, rapid breathing, and dehydration.

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Hyperosmolar Hyperglycemic Syndrome (HHS)

A serious condition with extremely high blood sugar, dehydration, and mental confusion, but without ketones like DKA.

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HHS: What's Different from DKA?

HHS involves extremely high blood sugar and dehydration like DKA, but lacks ketones, and often affects people with type 2 diabetes.

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HHS: Causes

Triggered by insufficient fluid intake, increasing mental depression, and excessive urination, often in people with poorly controlled type 2 diabetes.

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HHS: Lab Values

In HHS, blood glucose levels are extremely high (>34 mmol/L), serum osmolality is increased, and there are few to no ketones present.

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Insulin's Role

Insulin is a hormone responsible for helping glucose enter cells for energy. It lowers blood sugar levels.

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What Opposes Insulin?

Glucagon, epinephrine, growth hormone, and cortisol work against insulin by increasing glucose production and release, raising blood sugar levels.

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Type 1 Diabetes

An autoimmune disorder where the body destroys its own insulin-producing cells in the pancreas, leading to absolute insulin deficiency.

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Type 2 Diabetes

A condition where the body either doesn't produce enough insulin or can't use it properly (insulin resistance), leading to high blood sugar levels.

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Risk Factors for Type 2 Diabetes

Risk factors for type 2 diabetes include obesity, high blood pressure, high cholesterol, prediabetes, PCOS, certain psychiatric disorders, sleep apnea, and acanthosis nigricans.

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Cultural Considerations

Certain cultural groups, like Indigenous, Latin American, South Asian, Asian, and African populations, have a higher risk of developing type 2 diabetes.

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Type 2 Diabetes Symptoms

Type 2 diabetes often has a gradual onset, with symptoms like fatigue, recurrent infections, slow wound healing, vision changes, and painful neuropathy in the feet.

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Diabetes Management

People with diabetes need to manage their blood sugar levels through medication, diet, exercise, and monitoring.

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Study Notes

Diabetes Mellitus Overview

  • Diabetes mellitus (DM) is a collection of metabolic disorders, characterized by elevated blood glucose levels.
  • Abnormal insulin production, impaired insulin utilization, or both contribute to hyperglycemia.
  • Genetic, autoimmune, viral, and environmental factors (lifestyle, obesity, stress) are involved in the development of DM.
  • 65%-80% of individuals with DM die as a result of heart disease or stroke.
  • Type 1 DM (10% of cases) is characterized by an autoimmune attack on the pancreatic beta cells, resulting in a complete lack of insulin production.
  • Type 2 DM (90% of cases) is associated with insulin resistance, where the body's cells do not respond adequately to insulin.
  • Other types include gestational diabetes, prediabetes, and secondary diabetes. There are a total of 11 categories of diabetes mellitus.

Pathophysiology of Glucagon and Insulin

  • Glucagon is synthesized and released by the pancreas in response to low blood glucose, promoting glucose production and release, which is important during periods of fasting.
  • Insulin, the primary metabolic regulator, facilitates glucose transport into cells, lowering blood glucose.
  • Insulin is continuously released ("basal rate") and delivers "boluses" when food is ingested.
  • Insulin opposes glucagon, epinephrine, growth hormone, and cortisol to regulate blood glucose concentrations.
  • Target blood sugar levels are typically between 4-6/7 mmol/L.

Diabetes Diagnostics

  • Hemoglobin A1C measures glucose levels over a period (90-120 days), providing an indication of long-term blood sugar control.
  • Fasting plasma glucose measures blood glucose after an overnight fast, often used for diagnosis.
  • A random plasma glucose test measures blood glucose without regard to timing of meals, and is used if symptoms are present.
  • The OGTT measures blood glucose after consuming a glucose load of 75g, assessing how the body metabolizes glucose.

Diabetes Clinical Management

  • Type 1 DM treatment primarily involves exogenous insulin administration via injections or pumps.
  • Type 2 DM management often starts with lifestyle changes including nutrition, weight loss, exercise, and oral antihyperglycemic agents (OHAs).
  • OHAs aim to increase insulin production, enhance/improve insulin sensitivity and/or reduce glucose production. Metformin and Gluconorm are examples.
  • Insulin types are classified based on onset, peak, and duration of action (rapid-acting, short-acting, intermediate-acting, long-acting).

Diabetes Acute Complications

  • Hypoglycemia, a common acute complication, occurs when blood glucose levels fall below 4 mmol/L. This occurs when there is too much insulin, not enough food, or delays in timing of insulin, or both. 
  • Symptoms include sweating, trembling, palpitations, anxiety, hunger, nausea, tingling, disturbed sleep, weird dreams, lethargy, weakness, dizziness, confusion, headache, drowsiness, vision changes, difficulty speaking, and even unconsciousness. Severity depends on the blood glucose level.
  • Treatment involves administration of 15-20 grams of fast-acting carbohydrates.
  • Severe hypoglycemia requires intravenous dextrose and/or glucagon.
  • Hyperglycemia complications include diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic syndrome (HHS).

Diabetes Chronic Complications

  • Chronic complications include vascular damage (retinopathy, nephropathy, neuropathy), cardiovascular disease, infections, and others.
  • Vascular damage arises from the accumulation of damaging substances in blood vessels, including byproducts of glucose metabolism (e.g., sorbitol).
  • Risk factors for complications include long-term hyperglycemia and poor self-management.
  • Foot care is a crucial aspect of diabetes management, as patients with diabetes are highly susceptible to foot problems.

DM: Safety, Cultural, and Foot Care Tips

  • Important considerations for diabetic care include understanding a patient's needs and lifestyle changes.
  • Patients should be aware of various risk factors.
  • Regular foot examinations and proper foot care are crucial to prevent complications.
  • DM patients should be aware of safety measures and how to recognize and respond to their condition. Important to be careful when mixing medications (alcohol and Metformin).

DM and Alcohol

  • Alcohol can inhibit glucose production and may alter glucose levels, potentially leading to hypoglycemia/hyperglycemia.
  • Patients must exercise caution.
  • Open communication with healthcare providers about alcohol consumption is essential.
  • Metformin and alcohol may increase the risk of lactic acidosis.

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Test your knowledge on diabetes management and insulin functions. This quiz covers various aspects, including risk factors, complications, and exercise recommendations for individuals with diabetes. Enhance your understanding of how diabetes affects the body and the importance of monitoring blood glucose levels.

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