Podcast
Questions and Answers
What is the primary function of insulin in the body?
What is the primary function of insulin in the body?
- Promote the formation of glucose
- Stimulate glucose and potassium uptake (correct)
- Facilitate fat breakdown
- Break down proteins
Which process is responsible for the formation of glycogen?
Which process is responsible for the formation of glycogen?
- Glycogenesis (correct)
- Glycogenolysis
- Gluconeogenesis
- Glycolysis
Which statement is true regarding brain cells and glucose?
Which statement is true regarding brain cells and glucose?
- They can uptake glucose without insulin stimulation (correct)
- They require insulin to uptake glucose
- They do not require glucose for energy
- They can only use glucose derived from fats
What characterizes Type 1 Diabetes Mellitus (DM)?
What characterizes Type 1 Diabetes Mellitus (DM)?
What occurs when there is insufficient insulin in the body?
What occurs when there is insufficient insulin in the body?
Which process involves the breakdown of glucose to produce ATP?
Which process involves the breakdown of glucose to produce ATP?
What is a common characteristic of Type 2 Diabetes Mellitus?
What is a common characteristic of Type 2 Diabetes Mellitus?
Which test is used to determine if there is still insulin production in patients with Type 1 DM?
Which test is used to determine if there is still insulin production in patients with Type 1 DM?
Which medication is considered the first-line treatment for gestational diabetes mellitus?
Which medication is considered the first-line treatment for gestational diabetes mellitus?
What is a common side effect associated with metformin?
What is a common side effect associated with metformin?
Which of the following medications should be avoided within 48 hours of iodinated contrast administration?
Which of the following medications should be avoided within 48 hours of iodinated contrast administration?
Which class of medications includes Tolbutamide and Glipizide?
Which class of medications includes Tolbutamide and Glipizide?
What kind of allergy would potentially contraindicate the use of Sulfonylureas?
What kind of allergy would potentially contraindicate the use of Sulfonylureas?
Which of the following medications is considered safe to use in patients with a history of thyroid issues?
Which of the following medications is considered safe to use in patients with a history of thyroid issues?
Which drug is known to mask the symptoms of hypoglycemia?
Which drug is known to mask the symptoms of hypoglycemia?
Which of these medications should be monitored for its adverse effects on the thyroid?
Which of these medications should be monitored for its adverse effects on the thyroid?
Which DPP-4 inhibitor is associated with the risk of pancreatitis?
Which DPP-4 inhibitor is associated with the risk of pancreatitis?
Which DPP-4 inhibitor does not require renal adjustment?
Which DPP-4 inhibitor does not require renal adjustment?
What is the mechanism of action of acarbose?
What is the mechanism of action of acarbose?
What is a potential side effect of Canagliflozin?
What is a potential side effect of Canagliflozin?
In the case of a patient with T1 DM, what is the typical insulin dose range per day?
In the case of a patient with T1 DM, what is the typical insulin dose range per day?
What should be done for a patient whose blood glucose level is 210 mg/dl with a target of 120 mg/dl, given a correction factor of 30?
What should be done for a patient whose blood glucose level is 210 mg/dl with a target of 120 mg/dl, given a correction factor of 30?
Which dosing strategy is indicated for patients with an A1C of 8.5 - 10?
Which dosing strategy is indicated for patients with an A1C of 8.5 - 10?
Which of the following medications is indicated to reduce the risk of cardiovascular disease?
Which of the following medications is indicated to reduce the risk of cardiovascular disease?
What is the primary characteristic that distinguishes Type 1 diabetes from Type 2 diabetes?
What is the primary characteristic that distinguishes Type 1 diabetes from Type 2 diabetes?
Which measurement indicates that a patient has diabetes according to the diagnosis criteria?
Which measurement indicates that a patient has diabetes according to the diagnosis criteria?
What is the weight category for an adult female with a height of 160 cm and weight of 80 kg?
What is the weight category for an adult female with a height of 160 cm and weight of 80 kg?
When should Type 2 diabetes patients be followed up after diagnosis?
When should Type 2 diabetes patients be followed up after diagnosis?
What class of diabetes medication is metformin categorized under?
What class of diabetes medication is metformin categorized under?
Which of the following medications is NOT an SGLT-2 Inhibitor?
Which of the following medications is NOT an SGLT-2 Inhibitor?
Which is NOT a known risk factor for Type 2 diabetes?
Which is NOT a known risk factor for Type 2 diabetes?
What is the recommended frequency for checking Type 1 diabetes after diagnosis?
What is the recommended frequency for checking Type 1 diabetes after diagnosis?
Which insulin secretagogue belongs to the second generation?
Which insulin secretagogue belongs to the second generation?
What is the primary mechanism of insulin sensitizers like metformin?
What is the primary mechanism of insulin sensitizers like metformin?
Flashcards
What do beta cells produce?
What do beta cells produce?
Beta cells, located in the pancreatic islets, are responsible for producing and releasing insulin into the bloodstream.
What is the function of insulin?
What is the function of insulin?
Insulin's primary function is to facilitate the uptake of glucose from the bloodstream into cells, thereby lowering blood sugar levels. It also promotes the conversion of excess glucose into glycogen for storage.
What is glycolysis?
What is glycolysis?
Glycolysis is the metabolic pathway responsible for breaking down glucose into pyruvate, generating ATP (adenosine triphosphate) in the process.
Define glycogenesis.
Define glycogenesis.
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What is gluconeogenesis?
What is gluconeogenesis?
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Define glycogenolysis.
Define glycogenolysis.
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What is Type 1 Diabetes?
What is Type 1 Diabetes?
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What is Type 2 Diabetes?
What is Type 2 Diabetes?
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Metformin Side Effects
Metformin Side Effects
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Metformin - Diabetes Medication
Metformin - Diabetes Medication
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Gestational Diabetes
Gestational Diabetes
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Gestational Diabetes Treatment
Gestational Diabetes Treatment
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Glyburide for Gestational Diabetes
Glyburide for Gestational Diabetes
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Diabetes Mellitus (DM)
Diabetes Mellitus (DM)
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Risk Factors for Type 2 DM
Risk Factors for Type 2 DM
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Thiazolidinediones - Contraindications
Thiazolidinediones - Contraindications
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Sulfonylureas for Diabetes
Sulfonylureas for Diabetes
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Type 2 DM
Type 2 DM
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Meglitinides for Diabetes
Meglitinides for Diabetes
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Body Mass Index (BMI)
Body Mass Index (BMI)
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Hemoglobin A1c (A1C)
Hemoglobin A1c (A1C)
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Fasting Blood Glucose (FBG)
Fasting Blood Glucose (FBG)
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2-Hour Postprandial Glucose (2hrPG)
2-Hour Postprandial Glucose (2hrPG)
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Complications of DM
Complications of DM
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Insulin Sensitizers
Insulin Sensitizers
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Insulin Secretagogues
Insulin Secretagogues
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DPP-4 Inhibitors
DPP-4 Inhibitors
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Acarbose
Acarbose
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SGLT-2 Inhibitors
SGLT-2 Inhibitors
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Insulin
Insulin
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Target A1C
Target A1C
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Metformin
Metformin
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Correction Factor
Correction Factor
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Blood Glucose
Blood Glucose
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Study Notes
Diabetes From Zero To Hero Course
- Course offered by Dr/ Moaaz
- Course name: OTC Course from Zero to Hero
- Contact information provided: +201094718950
Diabetes Mellitus
- Beta cells in pancreatic islets secrete insulin
- Insulin breaks down glucose to ATP
- There are two types: Type 1 and Type 2
- Risk factors for type 1 DM include: Genetic Predisposition, Decreased Vitamin D levels, Cow's milk consumption, and Medications.
- Risk factors for type 2 DM include: Family history, Age over 35, BMI greater than 25, High Insulin Resistance
Processes in Diabetes
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Glycolysis: Breakdown of glucose to ATP
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Glycogenesis: Formation of glycogen
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Gluconeogenesis: Formation of glucose from non-carbohydrate sources
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Glycogenolysis: Breakdown of glycogen
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Insulin stimulates glucose and potassium uptake in all cells. Brain cells can utilize glucose without insulin stimulation.
Types of Diabetes
- Type 1 DM: Characterized by destruction of insulin-producing beta cells in the pancreas. A C-peptide test determines if insulin production is ongoing. The body may break down fats to make ketones, which can cause ketoacidosis
- Type 2 DM: Characterized by insulin resistance and a possible deficiency in insulin production. Insulin sensitivity in body cells can be affected.
Diabetes Insipidus
- Treated with ADH, Vasopressin and Desmopressin
- Vasopressin antidote is Phentolamine
Medications
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Desmopressin Acetate (Omegapress): Dosage and details on container provided.
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Insulin Sensitizers: Metformin, Thiazolidinediones
- Metformin: First line treatment for type 2 DM. Monitor kidney function. Avoid with iodinated contrast, drug interaction: topiramate.
- Thiazolidinediones (Pioglitazone, Rosiglitazone): Contraindicated in heart or hepatic issues
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Insulin Secretagogues:
- First-generation SU (Tolbutamide, Chlorpropamide), Second-generation SU (Glipizide, Glimepiride, Glyburide), Meglitinide (Repaglinide, Nateglinide).
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SGLT-2 Inhibitors: Canagliflozin, Dapagliflozin, Empagliflozin, Sotagliflozin
- Canagliflozin - Risk of fractures, Urinary Tract Infections (UTIs). New guidelines indicate this class of drug may lower risk of cardiovascular disease
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GLP-1 Analogues:
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Lixisenatide, Liraglutide, Dulaglutide, Semaglutide (injections)
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Liraglutide: Recombinant DNA, FDA approved to decrease weight.
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DPP-4 Inhibitors: Sitagliptin, Saxagliptin, Linagliptin, Vildagliptin. Saxagliptin not recommended in heart failure.
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**
Other Diabetes Information
- Diagnostic criteria: A1C > 6.5, Fasting blood glucose (FBG) > 126 mg/dL, 2-hour postprandial glucose (2hrPG) > 200 mg/dL can all be used to diagnose diabetes.
- Symptoms of High Blood Sugar (Hyperglycemia): Dry mouth, Thirst, Headaches, Weakness, Blurred vision, Frequent urination.
- Complications of Diabetes: 1) Microvascular disease (retina, kidney and nerve damage)
2) Macrovascular disease (coronary artery disease, cerebrovascular disease, peripheral artery disease) - Diabetes Treatment Schedule: Type 1 DM: Within 3-5 years for diagnosis, yearly follow-up once over 10 years old. Type 2 DM: Yearly follow-up at diagnosis.
- Insulin Dosing: T1 DM: 0.3 to 0.6 units per kilogram day, T2 DM 0.1 to 0.2 units per kilogram per day .
- Insulin Types: List of rapid-acting, short-acting, intermediate-acting, and long-acting insulins detailed.
- Insulin Considerations: Zinc is important for insulin synthesis and Chromium for insulin action.
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