Diabetes Management in Pregnancy

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Questions and Answers

What is the target fasting blood glucose level for pregnant women with diabetes?

  • ≤ 95 mg/dL (correct)
  • ≤ 100 mg/dL
  • ≤ 110 mg/dL
  • ≤ 80 mg/dL

How many diabetic mothers are approximately delivered by Cesarean section?

  • 70%
  • 50% (correct)
  • 90%
  • 30%

During which time frame should blood glucose levels be monitored to avoid hypoglycemia during pregnancy?

  • Midnight to 2 AM
  • 2 AM to 6 AM (correct)
  • 8 AM to 10 AM
  • 1 PM to 4 PM

What is emphasized as important for optimal glycemic control and pregnancy outcome prior to conception?

<p>Pre-pregnancy counseling (A)</p> Signup and view all the answers

What factor does NOT influence the mode of delivery for pregnant women with diabetes?

<p>Fetal heart rate (B)</p> Signup and view all the answers

What complication is associated with excessive fetal growth in infants of diabetic mothers?

<p>Macrosomia (D)</p> Signup and view all the answers

Which factor is NOT linked to the severity of congenital malformations in infants of diabetic mothers?

<p>Maternal physical activity (C)</p> Signup and view all the answers

What does elevated Glycosylated Hemoglobin A (HbA1c) levels indicate when measured before 14 weeks of gestation?

<p>Poor maternal glucose control over the past three months (A)</p> Signup and view all the answers

Which complication is linked to hypoxia and poor glycemic control in infants born to diabetic mothers?

<p>Fetal Death (C)</p> Signup and view all the answers

What is often evaluated during an ultrasound examination at 20-22 weeks of gestation in diabetic mothers?

<p>Cardiac defects and structural malformations (C)</p> Signup and view all the answers

Which factors allow for the continuation of pregnancy while awaiting labor onset?

<p>Young primigravidae or multiparae with a good obstetric history (D)</p> Signup and view all the answers

What is a critical method used to assess fetal condition during labor?

<p>Constant fetal monitoring (CTG) (A)</p> Signup and view all the answers

What potential problem may occur during labor that is specifically related to the fetal position?

<p>Shoulder dystocia (D)</p> Signup and view all the answers

What microscopic change may be observed in the placenta of a diabetic pregnancy?

<p>Villi edema and excessive syncytial knots (D)</p> Signup and view all the answers

Which sequence of events describes the pathology of diabetic ketoacidosis?

<p>Insulin resistance → Lipolysis → Enhanced ketogenesis → Fall in plasma HCO3 and pH (C)</p> Signup and view all the answers

What fasting plasma glucose level is considered critical for a good fetal outcome in women with gestational diabetes mellitus?

<p>90 mg/dL (A)</p> Signup and view all the answers

At what 2-hour glucose level after a 75 gm glucose test is a diagnosis of gestational diabetes made according to WHO criteria?

<p>140 mg/dL (C)</p> Signup and view all the answers

What percentage of total calories should carbohydrates comprise for normal weight women managing gestational diabetes?

<p>40-50% (A)</p> Signup and view all the answers

Which of the following complications is NOT associated with gestational diabetes mellitus?

<p>Gestational hypertension (C)</p> Signup and view all the answers

What is the recommended caloric intake range for overweight women diagnosed with gestational diabetes?

<p>1200-1800 kcal/day (B)</p> Signup and view all the answers

What is the diagnostic criterion for overt diabetes if fasting plasma glucose levels exceed which threshold?

<p>126 mg/dL (C)</p> Signup and view all the answers

What proportion of women with gestational diabetes mellitus may eventually require insulin therapy?

<p>25% (B)</p> Signup and view all the answers

Which of the following is a long-term risk for women who have experienced gestational diabetes?

<p>Development of type 2 diabetes (A)</p> Signup and view all the answers

What is one of the primary causes of neonatal deaths in diabetic pregnancies?

<p>Hypoglycemia (C)</p> Signup and view all the answers

What is the recommended calorie intake for an overweight pregnant woman with diabetes?

<p>24 kcal/kg (D)</p> Signup and view all the answers

What percentage of risk for a diabetic child is associated if both parents are diabetic?

<p>40% (D)</p> Signup and view all the answers

How often should antenatal appointments be conducted after week 20 of pregnancy for women with diabetes?

<p>Every two weeks (B)</p> Signup and view all the answers

What is a critical management step to achieve better pregnancy outcomes in diabetic women?

<p>Careful antenatal supervision and glycemic control (B)</p> Signup and view all the answers

What is a common characteristic of Type-1 diabetes mellitus?

<p>Absolute insulinopenia (C)</p> Signup and view all the answers

Which of the following factors may contribute to fetal overgrowth in diabetes?

<p>Elevated free fatty acids (C)</p> Signup and view all the answers

What is the significance of detecting glycosuria before the 20th week of pregnancy?

<p>It usually requires a glucose tolerance test. (B)</p> Signup and view all the answers

Which of the following constitutes a potential candidate for Gestational Diabetes Mellitus (GDM)?

<p>History of recurrent candidiasis (A)</p> Signup and view all the answers

Which test result indicates that a woman does not need a glucose tolerance test?

<p>Fasting plasma glucose ≥ 126 mg/dL on repeat testing (A)</p> Signup and view all the answers

What is a key factor affecting insulin resistance during pregnancy?

<p>Chronic low-grade inflammation (D)</p> Signup and view all the answers

When is routine screening for gestational diabetes typically recommended for high-risk individuals?

<p>Between 24 and 28 weeks of pregnancy (C)</p> Signup and view all the answers

Which condition may signal the need for a glucose tolerance test during pregnancy?

<p>Family history of diabetes (B)</p> Signup and view all the answers

What is the role of HDL cholesterol in the context of diabetes?

<p>It acts as a plasma antioxidant. (A)</p> Signup and view all the answers

What is the primary factor that increases insulin requirement during pregnancy?

<p>Altered carbohydrate metabolism (B)</p> Signup and view all the answers

Which of the following is NOT a complication associated with maternal diabetes during pregnancy?

<p>Puerperal sepsis (B)</p> Signup and view all the answers

How does vasculopathy affect pregnant women with diabetes?

<p>It predicts adverse pregnancy outcomes (D)</p> Signup and view all the answers

What is a potential fetal complication associated with maternal diabetes?

<p>Fetal macrosomia (D)</p> Signup and view all the answers

Which of the following is a common association seen in diabetes that may lead to polyhydramnios?

<p>Fetal hyperglycemia leading to polyuria (D)</p> Signup and view all the answers

What is a key predictive factor for the perinatal outcome in pregnant women with diabetic nephropathy?

<p>Proteinuria &gt; 3 g/24 hours (C)</p> Signup and view all the answers

Which of the following factors can precipitate ketoacidosis in pregnant diabetics?

<p>Hyperemesis and fasting (D)</p> Signup and view all the answers

What characterizes diabetic retinopathy in pregnant women with diabetes?

<p>Proliferative retinopathy with neovascularization (B)</p> Signup and view all the answers

What condition is most likely to occur due to prolonged labor in diabetic pregnant women?

<p>Shoulder dystocia (C)</p> Signup and view all the answers

What is the consequence of polyhydramnios during pregnancy?

<p>Increased maternal stress (A)</p> Signup and view all the answers

Flashcards

Self-monitoring of Capillary Blood Glucose

Regularly checking blood sugar levels using a device at home. This helps in managing diabetes during pregnancy.

Target Blood Glucose Levels

Blood sugar levels should be within a specific range for a healthy pregnancy. Fasting levels less than 95, post-meal levels less than 120, and nighttime levels above 60 are ideal.

Timing of Delivery

The timing of birth depends on the baby's development and good diabetes control. If everything is fine, it's aligned with the baby's maturity.

Mode of Delivery

The way a baby is born - whether by C-section or naturally - is influenced by blood sugar control, baby's size, complications, and pelvic size.

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Pre-Pregnancy Counseling

Counseling before pregnancy is important for women with diabetes. This aims to ensure good blood sugar control for a successful outcome.

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Macrosomia in infants of diabetic mothers

Excessive fetal growth caused by increased insulin secretion from the mother.

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Congenital Malformations in infants of diabetic mothers

Increased risk of birth defects in infants of diabetic mothers, especially if hyperglycemia is poorly controlled during the first trimester.

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Fetal Growth Restriction in infants of diabetic mothers

Poor fetal growth due to problems with blood flow to the placenta in diabetic mothers.

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Hypoglycemia in infants of diabetic mothers

Low blood sugar in a newborn due to sudden changes in insulin levels after birth.

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Glycosylated Hemoglobin A1c (HbA1c)

A blood test that measures average blood sugar levels over the past three months, indicating how well a diabetic mother has controlled her blood sugar.

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Shoulder dystocia

When a baby's shoulder gets stuck during delivery, making it difficult for the baby to come out.

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Waiting for Labour to Start

Pregnancy may continue until labour starts naturally if the mother has good health and history, and diabetes is well managed.

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Fetal Monitoring

Fetal monitoring is essential to assess the baby's health during pregnancy. Scalp electrodes are often used to measure fetal scalp blood pH.

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Diabetic Ketoacidosis

A condition that occurs when the mother's blood sugar levels become dangerously high, leading to acidosis.

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Placenta and Cord Abnormalities

The placenta may be larger than normal, the umbilical cord thicker, and there may be only one umbilical artery instead of the usual two.

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Carpenter & Coustan Modified 100gm Oral Glucose Test

A test used to diagnose gestational diabetes mellitus (GDM). A woman is diagnosed with GDM if she has a fasting glucose level above 95mg/dl or a 1 hour glucose level above 180 mg/dl or a 2 hour glucose level above 155mg/dl or a 3 hour glucose level above 140mg/dl based on venous plasma glucose levels during a 100gm oral glucose tolerance test.

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Gestational Diabetes Mellitus (GDM)

The most common type of diabetes during pregnancy. It occurs when the body can't produce enough insulin or use insulin properly, resulting in high blood sugar levels.

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Self-Monitoring of Blood Glucose for GDM

A simple way to keep track of blood sugar levels for women with GDM. They use a small device called a 'reflectance meter'.

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Frequent Antenatal Check-Ups for GDM

Regular checkups with your doctor are essential for women with GDM to monitor the health of the mother and baby. These checkups can help to identify any complications.

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Type 2 Diabetes

A type of diabetes that develops after pregnancy. It happens when the pancreas doesn't produce enough insulin and the body can't use insulin properly.

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Overt Diabetes in Pregnancy

A type of diabetes that the mother has before pregnancy. It can be either pre-existing or first detected during pregnancy.

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75gm Oral Glucose Test (WHO)

Another way to diagnose gestational diabetes. A 2-hour glucose value above 140mg/dL after a 75gm oral glucose tolerance test.

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White's Classification of Pregnant Diabetic Women

This classification system is used to categorize pregnant diabetic women based on the onset of diabetes and blood glucose levels. Class A diabetes can develop at any age.

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HbA1c (Glycosylated Hemoglobin A1c)

A blood test that measures average blood sugar levels over the past 2-3 months. It provides crucial information about how well a diabetic mom manages her blood sugar throughout pregnancy.

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Glycemic Control

A process where the mother's blood sugar levels are carefully controlled through diet and insulin to keep them close to normal levels throughout pregnancy.

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Diabetes Mellitus

A chronic metabolic disorder characterized by either insulin deficiency or resistance to insulin action.

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Pregnancy-induced Inflammation

A state of chronic low-grade inflammation during pregnancy, characterized by increased levels of C-reactive protein (CRP) and interleukin-6 (IL-6), which contribute to insulin resistance.

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Glucose Tolerance Test

A test used to assess the body's ability to handle sugar, particularly during pregnancy, by measuring blood glucose levels after consuming a sugary drink.

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Self-Monitoring of Blood Glucose

A process of regularly checking blood sugar using a home device, especially crucial for managing diabetes in pregnancy.

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Glycosuria in Pregnancy

The presence of glucose in the urine, often due to a lowered renal threshold for glucose during pregnancy.

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Macrosomia

Excessive fetal growth, often seen in infants of diabetic mothers, potentially linked to increased insulin production.

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Fetal Growth Restriction

Impaired fetal growth due to placental blood flow issues in diabetic mothers, potentially impacting nutrient delivery.

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Why is blood sugar regulation challenging during pregnancy?

Blood sugar levels during pregnancy are harder to regulate due to changes in how the body uses carbohydrates and insulin's effectiveness.

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Diabetes in pregnancy: What's the main threat?

Elevated blood sugar and its adverse effects on both the mother and the baby.

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What hormonal factors make blood sugar control difficult during pregnancy?

Pregnancy hormones like placental lactogen, estrogen, progesterone, and cortisol can interfere with insulin's action, making it harder to regulate blood sugar.

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How does insulin requirement change throughout pregnancy?

As pregnancy progresses, the body's insulin needs increase to accommodate the growing fetus and its energy requirements.

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How does diabetes increase the risk of preeclampsia?

The mother's body is more likely to develop preeclampsia, a dangerous condition involving high blood pressure and other symptoms, if she has diabetes.

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What vascular complications can worsen during pregnancy for diabetic women?

Damage to small blood vessels in the eyes (retinopathy), kidneys (nephropathy), heart (coronary artery disease), and nerves (neuropathy) can worsen during pregnancy.

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Why are infants born to mothers with diabetes often larger than average - macrosomia?

Babies born to mothers with diabetes are more likely to be larger than average due to increased insulin levels from the mother.

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What is the risk of hypoglycemia for infants of diabetic mothers?

The fetus is at risk for developing low blood sugar (hypoglycemia) after birth due to sudden changes in insulin levels.

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What is the risk of preterm labor for women with diabetes?

Diabetic women have an increased risk of having a baby prematurely due to various factors like infection or excess amniotic fluid.

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What factors can trigger ketoacidosis in pregnant diabetic women?

Long periods of fasting, hyperemesis (severe morning sickness), and infections can trigger diabetic ketoacidosis, a dangerous condition.

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Study Notes

  • Self-monitoring of capillary blood glucose is recommended for optimal glycemic control. Goals of capillary blood glucose levels (mg/dL) are: fasting ≤ 95; 2 hr. postprandial ≤ 120; 2 am to 6 am ≥ 60; Mean 100 and HbA1c ≤ 6 (ACOG-2005).
  • Timing of delivery should be with fetal maturation provided diabetes is well controlled and fetal surveillance is normal.
  • Mode of delivery depends on the level of glycemic control, fetal size, associated complications (if any [preeclampsia]), and pelvic adequacy. As such 50% of diabetic mothers are delivered by cesarean section. However, selected women may be considered for induction of labor and/or vaginal delivery.
  • Pre-pregnancy counseling is ideally done for all such women for optimum glycemic control a pregnancy outcome.

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