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Questions and Answers

What is the focus of Knudson’s 2-Hit Hypothesis?

  • Mosaicism and its implications for genetic disorders
  • Inheritance patterns in autosomal recessive disorders
  • Tumorigenesis in retinoblastoma and phakomatoses (correct)
  • The genetic basis of multifactorial diseases
  • Which type of chromosome analysis is specifically used to detect aneuploidy?

  • Whole exome sequencing
  • Fluorescence in situ hybridization (FISH)
  • Karyotyping (correct)
  • Comparative genomic hybridization (CGH)
  • What is the role of genetic counseling in the management of genetic disease?

  • To perform surgical interventions for genetic abnormalities
  • To facilitate a complete understanding of inheritance and options (correct)
  • To offer psychological evaluation and therapy
  • To provide laboratory testing for chromosomal abnormalities
  • What aspect of tear film is primarily responsible for protecting the ocular surface?

    <p>Lipid layer (B)</p> Signup and view all the answers

    Which layer of the cornea is responsible for the majority of its thickness?

    <p>Stroma layer (B)</p> Signup and view all the answers

    Which of the following is a common feature of complex genetic diseases?

    <p>Polygenic contributions and environmental influences (C)</p> Signup and view all the answers

    What is a primary function of tear secretion?

    <p>To maintain optimal pH for corneal health (A)</p> Signup and view all the answers

    Which term describes the process by which one X chromosome is randomly inactivated in females?

    <p>Lyonization (B)</p> Signup and view all the answers

    What is the purpose of the blood-aqueous barrier?

    <p>To prevent the passage of harmful substances into the eye (A)</p> Signup and view all the answers

    Which of the following is NOT part of the composition of the aqueous humor?

    <p>Lipids (D)</p> Signup and view all the answers

    What is a potential clinical implication of a breakdown in the blood-aqueous barrier?

    <p>Increased risk of infection in the eye (C)</p> Signup and view all the answers

    Which structural component is least likely to be affected by cataract formation?

    <p>Capsule (D)</p> Signup and view all the answers

    What metabolite is primarily associated with the formation of sugar cataracts?

    <p>Glucose (D)</p> Signup and view all the answers

    Which of the following is a property of the lens that contributes to its transparency?

    <p>Uniform refractive index (B)</p> Signup and view all the answers

    What is the primary function of the ciliary body in relation to aqueous humor?

    <p>Production and secretion of aqueous humor (B)</p> Signup and view all the answers

    Which component in the vitreous is essential for its viscosity?

    <p>Hyaluronan (D)</p> Signup and view all the answers

    Which bone is NOT part of the bony orbit?

    <p>Temporal bone (D)</p> Signup and view all the answers

    Which of the following pairs of bones form the lateral wall of the bony orbit?

    <p>Zygomatic bone and Sphenoid bone (B)</p> Signup and view all the answers

    Which structure is located in the anterior part of the bony orbit?

    <p>Frontoethmoidal suture (A)</p> Signup and view all the answers

    The optic canal is formed by which two bones?

    <p>Lesser wing of sphenoid and Ethmoid bones (A)</p> Signup and view all the answers

    Which of the following bones contributes to the floor of the bony orbit?

    <p>Maxillary bone (B)</p> Signup and view all the answers

    What is the function of the lacrimal sac fossa?

    <p>Houses the nasolacrimal duct (A)</p> Signup and view all the answers

    Which of these bones is primarily associated with the medial wall of the bony orbit?

    <p>Ethmoid bone (C)</p> Signup and view all the answers

    Which fissure is located between the greater and lesser wings of the sphenoid bone?

    <p>Superior orbital fissure (B)</p> Signup and view all the answers

    Which structure is NOT attached to the important landmark mentioned?

    <p>Medial canthal tendon (A)</p> Signup and view all the answers

    What is the main function of the optic canal?

    <p>Transmits the ophthalmic artery (C)</p> Signup and view all the answers

    Where is the infraorbital canal located?

    <p>Continuing from the infraorbital groove (A)</p> Signup and view all the answers

    What does the nasolacrimal duct primarily connect?

    <p>The lacrimal sac fossa to the inferior meatus of the nose (A)</p> Signup and view all the answers

    Which of the following foramina transmits the anterior ethmoidal vessels and nerve?

    <p>Anterior ethmoidal foramen (D)</p> Signup and view all the answers

    What structure lies at the junction of the roof and medial wall of the orbit?

    <p>Posterior ethmoidal foramen (D)</p> Signup and view all the answers

    Which nerve does the supraorbital foramen transmit?

    <p>Ophthalmic nerve (V1) (D)</p> Signup and view all the answers

    What is the approximate length of the superior orbital fissure?

    <p>22 mm (C)</p> Signup and view all the answers

    Which committee is responsible for studying aging-related issues?

    <p>Committee on Aging (B)</p> Signup and view all the answers

    Who served as the Primary Reviewer and Chair of the Practicing Ophthalmologists Advisory Committee for Education?

    <p>Bradley D.Fouraker, MD (A)</p> Signup and view all the answers

    Which city is Deepa Abraham, MD, affiliated with?

    <p>Seattle, Washington (A)</p> Signup and view all the answers

    Which of the following locations is associated with Michelle S.Ying, MD, MSPH?

    <p>Ladson, South Carolina (A)</p> Signup and view all the answers

    Which committee assists in developing Study Questions and Answers?

    <p>Self-Assessment Committee (D)</p> Signup and view all the answers

    Which individual is associated with the Vision Rehabilitation Committee?

    <p>Mona A.Kaleem, MD (C)</p> Signup and view all the answers

    Identify the state where David A.Mackey, MD, is located.

    <p>Western Australia (B)</p> Signup and view all the answers

    Which of the following individuals is associated with Shawnee Mission, Kansas?

    <p>Ravi S.J.Singh, MD (B)</p> Signup and view all the answers

    Which muscle originates from the lesser wing of the sphenoid bone?

    <p>Levator palpebrae superioris (C)</p> Signup and view all the answers

    What is the length of the inferior rectus muscle?

    <p>40 mm (C)</p> Signup and view all the answers

    Which muscle is primarily responsible for lifting the upper eyelid?

    <p>Levator palpebrae superioris (C)</p> Signup and view all the answers

    Where does the inferior oblique muscle originate?

    <p>Orbital plate of the maxillary bone (A)</p> Signup and view all the answers

    Which cranial nerve innervates the superior oblique muscle?

    <p>CN IV (B)</p> Signup and view all the answers

    What is the primary action of the lateral rectus muscle?

    <p>Abduction of the eye (A)</p> Signup and view all the answers

    Which extraocular muscle has the longest tendon?

    <p>Inferior oblique (D)</p> Signup and view all the answers

    What is the blood supply for the medial rectus muscle?

    <p>Branches of the ophthalmic artery (D)</p> Signup and view all the answers

    Which muscle extends posteriorly, laterally, and superiorly to insert into the globe?

    <p>Inferior oblique (A)</p> Signup and view all the answers

    How long is the lateral rectus muscle?

    <p>40.6 mm (C)</p> Signup and view all the answers

    Which cranial nerve innervates the inferior rectus muscle?

    <p>CN III (A)</p> Signup and view all the answers

    Which muscle originates from the annulus of Zinn at the orbital apex?

    <p>Superior rectus (B)</p> Signup and view all the answers

    What is the length of the superior oblique muscle?

    <p>40 mm (C), 40 mm (D)</p> Signup and view all the answers

    Which statement about the annulus of Zinn is incorrect?

    <p>It is located at the base of the skull. (A)</p> Signup and view all the answers

    Flashcards

    American Academy of Ophthalmology

    A professional organization for ophthalmologists in the United States dedicated to advancing the science and practice of ophthalmology.

    BCSC

    The Basic and Clinical Science Course offered by the American Academy of Ophthalmology, providing comprehensive ophthalmology education.

    Committee on Aging

    A specialized committee within the American Academy of Ophthalmology focusing on ophthalmological issues related to aging.

    Vision Rehabilitation Committee

    A committee dedicated to improving vision rehabilitation services and resources for patients with visual impairments.

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    Practicing Ophthalmologists Advisory Committee for Education

    A committee aimed at providing guidance and recommendations to ensure the quality and relevance of educational programs for practicing ophthalmologists.

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    Self-Assessment Committee

    A committee that develops and oversees self-assessment materials and resources for ophthalmologists to assess their knowledge and skills.

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    European Board of Ophthalmology

    An organization responsible for setting standards and certifying ophthalmologists across Europe.

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    What is the purpose of the Practicing Ophthalmologists Advisory Committee for Education?

    The POACE is dedicated to providing guidance and recommendations to ensure the quality and relevance of educational programs for practicing ophthalmologists.

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    Orbital Bones

    The seven bones that form the bony socket of the eye (orbit).

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    Frontal Bone

    The bone that forms the forehead and contributes to the roof of the orbit.

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    Zygomatic Bone

    The cheekbone, contributing to the lateral (side) wall of the orbit.

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    Maxillary Bone

    The bone that forms the upper jaw and part of the floor of the orbit.

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    Ethmoid Bone

    A complex bone located between the eyes, contributing to the roof and medial wall of the orbit.

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    Lacrimal Bone

    The smallest facial bone, forming part of the medial wall of the orbit and containing the lacrimal sac.

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    Sphenoid Bone

    A butterfly-shaped bone at the base of the skull, with wings that contribute to the orbit.

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    Optic Canal

    An opening in the sphenoid bone that allows the optic nerve to pass from the brain to the eye.

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    Endothelium

    A thin layer of cells that lines the inner surface of blood vessels and lymphatic vessels.

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    Aqueous Humor

    A clear fluid that fills the space between the cornea and the lens of the eye, providing nutrients to the lens and cornea.

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    Iris

    The colored part of the eye that controls the amount of light entering the pupil.

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    Ciliary Body

    The structure within the eye responsible for producing aqueous humor and adjusting the shape of the lens for focusing.

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    Blood-Aqueous Barrier

    A protective barrier that prevents harmful substances from entering the aqueous humor.

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    Lens

    The transparent structure within the eye that focuses light onto the retina.

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    Vitreous

    A transparent, jelly-like substance that fills the space between the lens and the retina, helping to maintain the shape of the eye.

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    Transparency of the Lens

    The lens's ability to allow light to pass through it, crucial for vision.

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    Lateral Rectus Muscle Attachment

    The lateral rectus muscle attaches to the lateral orbital wall at the lateral orbital tubercle, which is an important landmark for other structures.

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    Suspensory Ligament of the Eyeball

    Also known as the Lockwood suspensory ligament, this ligament attaches to the lateral orbital tubercle, supporting the eyeball and keeping it in place.

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    Lateral Canthal Tendon

    This tendon attaches to the lateral orbital tubercle, a part of the lateral orbital wall, forming the outer corner of the eyelid.

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    Levator Aponeurosis Horn

    The lateral horn of the levator aponeurosis, a part of the eyelid lifting muscle, also attaches to the lateral orbital tubercle.

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    Optic Canal Location

    The optic canal, carrying the optic nerve and ophthalmic artery, is found within the sphenoid bone, passing from the middle cranial fossa to the orbital apex.

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    Optic Canal Contents

    The optic canal carries the optic nerve, ophthalmic artery, and sympathetic fibers from the carotid plexus.

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    Supraorbital Foramen Location

    The supraorbital foramen, transmitting vessels and the supraorbital nerve, is located at the medial third of the superior orbital margin.

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    Nasolacrimal Duct Path

    The nasolacrimal duct descends from the lacrimal sac fossa into the inferior meatus of the nose, carrying tears.

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    What are the origins of the superior rectus muscle?

    The superior rectus muscle originates from the upper tendon of the annulus of Zinn.

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    What are the origins of the inferior rectus muscle?

    The inferior rectus muscle originates from the inferior tendon of the annulus of Zinn.

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    Where does the levator palpebrae superioris muscle originate?

    The levator palpebrae superioris muscle originates from the lesser wing of the sphenoid bone, just superior to the annulus of Zinn.

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    Where does the superior oblique muscle originate?

    The superior oblique muscle originates from the periosteum of the body of the sphenoid bone, above and medial to the optic foramen.

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    Where does the inferior oblique muscle originate?

    The inferior oblique muscle originates from a depression on the orbital plate of the maxillary bone, near the fossa for the lacrimal sac.

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    What is the annulus of Zinn?

    The annulus of Zinn is a fibrous ring that surrounds the optic canal and serves as the origin for several extraocular muscles.

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    What is the function of the medial rectus muscle?

    The medial rectus muscle is responsible for adduction, which means moving the eye inward towards the nose.

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    What is the function of the inferior rectus muscle?

    The inferior rectus muscle helps the eye to look down.

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    What is the function of the lateral rectus muscle?

    The lateral rectus muscle is responsible for abduction, which means moving the eye outward.

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    What is the function of the superior rectus muscle?

    The superior rectus muscle helps the eye to look up.

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    What is the function of the superior oblique muscle?

    The superior oblique muscle helps the eye to rotate inward and down.

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    What is the function of the inferior oblique muscle?

    The inferior oblique muscle helps the eye to rotate outward and up.

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    What is the purpose of the levator palpebrae superioris muscle?

    The levator palpebrae superioris muscle is responsible for raising the upper eyelid.

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    What is the difference between abduction and adduction of the eye?

    Abduction is the movement of the eye outward away from the nose, while adduction is the movement of the eye inward towards the nose.

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    Aneuploidy

    An abnormal number of chromosomes in a cell, typically caused by a gain or loss of one or more chromosomes.

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    Mosaicism

    The presence of two or more genetically distinct cell lines within an individual, arising from a single fertilized egg.

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    Knudson's 2-Hit Hypothesis

    A theory that explains the development of certain cancers, specifically requiring two mutations in a specific gene to cause disease, typically in tumor suppressor genes.

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    Lyonization

    The process of X-chromosome inactivation in females, where one X chromosome becomes inactive in each cell, ensuring dosage compensation between males and females.

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    What are polygenic and multifactorial inheritance?

    Polygenic inheritance refers to traits influenced by multiple genes, while multifactorial inheritance involves both multiple genes and environmental factors.

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    Pharmacogenetics

    The study of how genetic variations influence individual responses to medications, including efficacy and adverse effects.

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    Genetic Counseling

    A process that helps individuals understand the risks and options related to genetic conditions, including inheritance patterns, testing, and reproductive choices.

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    Reproductive Issues in Genetic Counseling

    These involve discussions about family planning, prenatal testing, reproductive technologies, and the potential for genetic conditions to affect future generations.

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