18 Questions
Which hormone is considered weakly active but can become a strong androgen upon conversion to testosterone?
DHEA
What percentage of women of reproductive age experience androgen excess in polycystic ovary syndrome?
10%-15%
Which condition is characterized by at least two out of the three criteria: ovulatory abnormalities, hyperandrogenism, or polycystic ovarian morphology?
Polycystic ovary syndrome
Which method is commonly used for measuring total serum steroid hormone concentrations?
Immunoassay
In cases where SHBG concentrations are altered, which measurements are argued to more accurately reflect androgen status?
Free or bioavailable testosterone measurements
Which of the following is a common clinical sign associated with polycystic ovary syndrome?
Androgen excess
Which of the following is the MOST significant physiological change that occurs during pregnancy?
Increased blood volume
What is the primary reason for the decrease in hemoglobin concentration during pregnancy?
Increased blood volume
What is the main reason for the increase in cardiac output during pregnancy?
Increased blood volume
What is the primary reason for the decrease in BUN and creatinine levels during pregnancy?
Increased glomerular filtration rate
Which of the following is the MOST significant limitation of immunoassays for measuring DHEA-S?
Lack of specificity due to cross-reactivity
Which of the following methods is considered the gold standard for DHEA-S measurement?
Gas chromatography-mass spectrometry (GC-MS)
Which of the following methods is routinely used in clinical practice to estimate free testosterone?
Equilibrium dialysis
What is the principle behind the estimation of free testosterone by adding a radiolabeled compound?
The radiolabeled compound competes with free testosterone for binding sites on proteins.
What is the recommended practice for measuring serum total testosterone to screen for deficiency?
Measure in a morning collection.
Which of the following statements about dehydroepiandrosterone (DHEA) is correct?
DHEA is secreted by the adrenal cortex in response to ACTH.
Why do DHEA-S concentrations not exhibit a circadian rhythm?
DHEA-S has a longer circulating half-life.
Which method is NOT routinely used in clinical practice to estimate testosterone fractions?
High-performance liquid chromatography (HPLC)
Learn about the measurement of DHEA-S using nonisotopic immunoassays and other methods like competitive protein-binding assays and GC-MS. Understand the cross-reactivity of DHEA-S immunoassays with related steroids and the impact of pregnancy on physiological changes affecting biochemical analytes.
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