DHEA-S Measurement and Pregnancy-Related Analyte Changes
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Questions and Answers

Which hormone is considered weakly active but can become a strong androgen upon conversion to testosterone?

  • DHEA (correct)
  • DHEA-S
  • Androstenedione
  • DHT
  • What percentage of women of reproductive age experience androgen excess in polycystic ovary syndrome?

  • 10%-15% (correct)
  • 20%-25%
  • 5%-8%
  • 15%-20%
  • Which condition is characterized by at least two out of the three criteria: ovulatory abnormalities, hyperandrogenism, or polycystic ovarian morphology?

  • Primary hypogonadism
  • Hypogonadotropic hypogonadism
  • Polycystic ovary syndrome (correct)
  • Hypergonadotropic hypogonadism
  • Which method is commonly used for measuring total serum steroid hormone concentrations?

    <p>Immunoassay</p> Signup and view all the answers

    In cases where SHBG concentrations are altered, which measurements are argued to more accurately reflect androgen status?

    <p>Free or bioavailable testosterone measurements</p> Signup and view all the answers

    Which of the following is a common clinical sign associated with polycystic ovary syndrome?

    <p>Androgen excess</p> Signup and view all the answers

    Which of the following is the MOST significant physiological change that occurs during pregnancy?

    <p>Increased blood volume</p> Signup and view all the answers

    What is the primary reason for the decrease in hemoglobin concentration during pregnancy?

    <p>Increased blood volume</p> Signup and view all the answers

    What is the main reason for the increase in cardiac output during pregnancy?

    <p>Increased blood volume</p> Signup and view all the answers

    What is the primary reason for the decrease in BUN and creatinine levels during pregnancy?

    <p>Increased glomerular filtration rate</p> Signup and view all the answers

    Which of the following is the MOST significant limitation of immunoassays for measuring DHEA-S?

    <p>Lack of specificity due to cross-reactivity</p> Signup and view all the answers

    Which of the following methods is considered the gold standard for DHEA-S measurement?

    <p>Gas chromatography-mass spectrometry (GC-MS)</p> Signup and view all the answers

    Which of the following methods is routinely used in clinical practice to estimate free testosterone?

    <p>Equilibrium dialysis</p> Signup and view all the answers

    What is the principle behind the estimation of free testosterone by adding a radiolabeled compound?

    <p>The radiolabeled compound competes with free testosterone for binding sites on proteins.</p> Signup and view all the answers

    What is the recommended practice for measuring serum total testosterone to screen for deficiency?

    <p>Measure in a morning collection.</p> Signup and view all the answers

    Which of the following statements about dehydroepiandrosterone (DHEA) is correct?

    <p>DHEA is secreted by the adrenal cortex in response to ACTH.</p> Signup and view all the answers

    Why do DHEA-S concentrations not exhibit a circadian rhythm?

    <p>DHEA-S has a longer circulating half-life.</p> Signup and view all the answers

    Which method is NOT routinely used in clinical practice to estimate testosterone fractions?

    <p>High-performance liquid chromatography (HPLC)</p> Signup and view all the answers

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