DHEA-S Measurement and Pregnancy-Related Analyte Changes
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Questions and Answers

Which hormone is considered weakly active but can become a strong androgen upon conversion to testosterone?

  • DHEA (correct)
  • DHEA-S
  • Androstenedione
  • DHT

What percentage of women of reproductive age experience androgen excess in polycystic ovary syndrome?

  • 10%-15% (correct)
  • 20%-25%
  • 5%-8%
  • 15%-20%

Which condition is characterized by at least two out of the three criteria: ovulatory abnormalities, hyperandrogenism, or polycystic ovarian morphology?

  • Primary hypogonadism
  • Hypogonadotropic hypogonadism
  • Polycystic ovary syndrome (correct)
  • Hypergonadotropic hypogonadism

Which method is commonly used for measuring total serum steroid hormone concentrations?

<p>Immunoassay (C)</p> Signup and view all the answers

In cases where SHBG concentrations are altered, which measurements are argued to more accurately reflect androgen status?

<p>Free or bioavailable testosterone measurements (D)</p> Signup and view all the answers

Which of the following is a common clinical sign associated with polycystic ovary syndrome?

<p>Androgen excess (C)</p> Signup and view all the answers

Which of the following is the MOST significant physiological change that occurs during pregnancy?

<p>Increased blood volume (C)</p> Signup and view all the answers

What is the primary reason for the decrease in hemoglobin concentration during pregnancy?

<p>Increased blood volume (A)</p> Signup and view all the answers

What is the main reason for the increase in cardiac output during pregnancy?

<p>Increased blood volume (B)</p> Signup and view all the answers

What is the primary reason for the decrease in BUN and creatinine levels during pregnancy?

<p>Increased glomerular filtration rate (B)</p> Signup and view all the answers

Which of the following is the MOST significant limitation of immunoassays for measuring DHEA-S?

<p>Lack of specificity due to cross-reactivity (B)</p> Signup and view all the answers

Which of the following methods is considered the gold standard for DHEA-S measurement?

<p>Gas chromatography-mass spectrometry (GC-MS) (C)</p> Signup and view all the answers

Which of the following methods is routinely used in clinical practice to estimate free testosterone?

<p>Equilibrium dialysis (A)</p> Signup and view all the answers

What is the principle behind the estimation of free testosterone by adding a radiolabeled compound?

<p>The radiolabeled compound competes with free testosterone for binding sites on proteins. (D)</p> Signup and view all the answers

What is the recommended practice for measuring serum total testosterone to screen for deficiency?

<p>Measure in a morning collection. (A)</p> Signup and view all the answers

Which of the following statements about dehydroepiandrosterone (DHEA) is correct?

<p>DHEA is secreted by the adrenal cortex in response to ACTH. (C)</p> Signup and view all the answers

Why do DHEA-S concentrations not exhibit a circadian rhythm?

<p>DHEA-S has a longer circulating half-life. (C)</p> Signup and view all the answers

Which method is NOT routinely used in clinical practice to estimate testosterone fractions?

<p>High-performance liquid chromatography (HPLC) (B)</p> Signup and view all the answers

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