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Desonide in Dermatology Quiz

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Questions and Answers

What is the primary use of Desonide in dermatology?

To increase vasodilation

To promote wound healing

To stimulate cytokine release

To reduce swelling and redness (correct)

How does Desonide suppress inflammation?

By increasing vasodilation

By promoting leukocyte migration

By inhibiting cytokine release (correct)

By enhancing immune cell activity

In a clinical trial evaluating vasoconstrictive properties, Desonide Gel 0.05% was compared to all of the following EXCEPT:

DesOwen Lotion (desonide lotion 0.05%)

Cyclocort Cream (amcinonide 0.1%)

Triamcinolone acetonide cream 0.1% (correct)

Hydrocortisone cream 0.5% (low potency)

What is the main mechanism of action of Desonide in reducing redness?

Reducing vasodilation Signup and view all the answers

Which of the following is NOT a formulation in which Desonide is available?

Oral tablets Signup and view all the answers

How does Desonide modulate the immune response in the skin?

By suppressing leukocyte migration Signup and view all the answers

What was the objective of the clinical trial-3?

To observe and analyze the clinical efficacy of mucopolysaccharide polysulfate (MPS) ointment combined with desonide ointment in treatment of infantile eczema Signup and view all the answers

What was the outcome of the clinical trial-4?

Significant improvements in IGA scores at day 3 and day 7 Signup and view all the answers

What is the purpose of comparing Desonide with other topical corticosteroids or non-steroidal alternatives in some trials?

To assess its relative efficacy and safety Signup and view all the answers

What was the study design for Clinical trial-2?

Multicenter open-label study in pediatric subjects with moderate to severe Atopic Dermatitis Signup and view all the answers

What was the gender distribution in the study designed to compare the vasoconstriction effect of Desonide formulation?

(6M; 30F; 27 Caucasian; 3 Hispanic; 6 Asian) Signup and view all the answers

What was observed in the study designed to compare the vasoconstriction effect of Desonide formulation?

Vasoconstriction potency ranking for Desonide Gel 0.05% equivalent to that of DesOwenCI Lotion 0.05% Signup and view all the answers

What was the main focus of Clinical trial-2?

(evaluating the safety and systemic tolerance of Desonide Gel 0.05%) Signup and view all the answers

What is being compared in Clinical trial-3?

(mucopolysaccharide polysulfate ointment combined with desonide ointment) Signup and view all the answers

What was observed in Clinical trial-2 after four weeks of twice-daily applications?

(100% subjects showed normal adrenal response) Signup and view all the answers