Desonide in Dermatology Quiz
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Questions and Answers

What is the primary use of Desonide in dermatology?

  • To increase vasodilation
  • To promote wound healing
  • To stimulate cytokine release
  • To reduce swelling and redness (correct)

How does Desonide suppress inflammation?

  • By increasing vasodilation
  • By promoting leukocyte migration
  • By inhibiting cytokine release (correct)
  • By enhancing immune cell activity

In a clinical trial evaluating vasoconstrictive properties, Desonide Gel 0.05% was compared to all of the following EXCEPT:

  • DesOwen Lotion (desonide lotion 0.05%)
  • Cyclocort Cream (amcinonide 0.1%)
  • Triamcinolone acetonide cream 0.1% (correct)
  • Hydrocortisone cream 0.5% (low potency)

What is the main mechanism of action of Desonide in reducing redness?

<p>Reducing vasodilation (B)</p> Signup and view all the answers

Which of the following is NOT a formulation in which Desonide is available?

<p>Oral tablets (B)</p> Signup and view all the answers

How does Desonide modulate the immune response in the skin?

<p>By suppressing leukocyte migration (D)</p> Signup and view all the answers

What was the objective of the clinical trial-3?

<p>To observe and analyze the clinical efficacy of mucopolysaccharide polysulfate (MPS) ointment combined with desonide ointment in treatment of infantile eczema (D)</p> Signup and view all the answers

What was the outcome of the clinical trial-4?

<p>Significant improvements in IGA scores at day 3 and day 7 (B)</p> Signup and view all the answers

What is the purpose of comparing Desonide with other topical corticosteroids or non-steroidal alternatives in some trials?

<p>To assess its relative efficacy and safety (B)</p> Signup and view all the answers

What was the study design for Clinical trial-2?

<p>Multicenter open-label study in pediatric subjects with moderate to severe Atopic Dermatitis (A)</p> Signup and view all the answers

What was the gender distribution in the study designed to compare the vasoconstriction effect of Desonide formulation?

<p>(6M; 30F; 27 Caucasian; 3 Hispanic; 6 Asian) (B)</p> Signup and view all the answers

What was observed in the study designed to compare the vasoconstriction effect of Desonide formulation?

<p>Vasoconstriction potency ranking for Desonide Gel 0.05% equivalent to that of DesOwenCI Lotion 0.05% (C)</p> Signup and view all the answers

What was the main focus of Clinical trial-2?

<p>(evaluating the safety and systemic tolerance of Desonide Gel 0.05%) (A)</p> Signup and view all the answers

What is being compared in Clinical trial-3?

<p>(mucopolysaccharide polysulfate ointment combined with desonide ointment) (D)</p> Signup and view all the answers

What was observed in Clinical trial-2 after four weeks of twice-daily applications?

<p>(100% subjects showed normal adrenal response) (D)</p> Signup and view all the answers

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