Podcast
Questions and Answers
Which of the following is a primary skin lesion?
Which of the following is a primary skin lesion?
What is the correct term for a skin lesion that has a raised, solid, round or oval shape and is less than 1 cm in diameter?
What is the correct term for a skin lesion that has a raised, solid, round or oval shape and is less than 1 cm in diameter?
Which of the following is NOT a characteristic used to describe the borders/margins of a skin lesion?
Which of the following is NOT a characteristic used to describe the borders/margins of a skin lesion?
What is the fourth step in the process of skin cell formation?
What is the fourth step in the process of skin cell formation?
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Which of the following is a characteristic of a skin lesion described as "annular"?
Which of the following is a characteristic of a skin lesion described as "annular"?
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Which layer of the skin contains hair follicles, nerve endings, sweat glands, and connective tissue?
Which layer of the skin contains hair follicles, nerve endings, sweat glands, and connective tissue?
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What type of skin disorder involves papules and plaques?
What type of skin disorder involves papules and plaques?
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Which of the following is a secondary skin lesion?
Which of the following is a secondary skin lesion?
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Which of the following is NOT a common site for lichen simplex chronicus?
Which of the following is NOT a common site for lichen simplex chronicus?
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What is the most common treatment for nummular eczema?
What is the most common treatment for nummular eczema?
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Which of the following is a characteristic feature of contact dermatitis?
Which of the following is a characteristic feature of contact dermatitis?
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Which of the following is a common treatment for atopic dermatitis?
Which of the following is a common treatment for atopic dermatitis?
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Which of the following is a common eliciting factor for atopic dermatitis?
Which of the following is a common eliciting factor for atopic dermatitis?
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Which of the following is a distinguishing feature of seborrheic dermatitis?
Which of the following is a distinguishing feature of seborrheic dermatitis?
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Which of the following conditions is most likely to be exacerbated by scratching?
Which of the following conditions is most likely to be exacerbated by scratching?
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Which of the following conditions is commonly associated with venous insufficiency?
Which of the following conditions is commonly associated with venous insufficiency?
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Which of the following treatments is most likely to be used for severe, intractable cases of atopic dermatitis?
Which of the following treatments is most likely to be used for severe, intractable cases of atopic dermatitis?
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Which of the following is a common trigger for seborrheic dermatitis?
Which of the following is a common trigger for seborrheic dermatitis?
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Which of the following conditions is characterized by a 'herald patch'?
Which of the following conditions is characterized by a 'herald patch'?
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A 25-year-old woman presents with red, scaly patches on her elbows and knees, along with pitting of her fingernails. Which of the following diagnoses is most likely?
A 25-year-old woman presents with red, scaly patches on her elbows and knees, along with pitting of her fingernails. Which of the following diagnoses is most likely?
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What is the most common trigger for Perioral Dermatitis?
What is the most common trigger for Perioral Dermatitis?
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What is the typical treatment for Fixed Drug Eruption?
What is the typical treatment for Fixed Drug Eruption?
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Which of the following is NOT a characteristic of Lichen Planus?
Which of the following is NOT a characteristic of Lichen Planus?
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A 45-year-old man presents with yellow, greasy scales on his scalp and eyebrows. This condition is most likely:
A 45-year-old man presents with yellow, greasy scales on his scalp and eyebrows. This condition is most likely:
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What is the typical course of Pityriasis Rosea?
What is the typical course of Pityriasis Rosea?
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Which of the following conditions is often triggered by a strep infection?
Which of the following conditions is often triggered by a strep infection?
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Which of these conditions is characterized by a 'Christmas tree' pattern?
Which of these conditions is characterized by a 'Christmas tree' pattern?
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What is a common characteristic of both Psoriasis and Seborrheic Dermatitis?
What is a common characteristic of both Psoriasis and Seborrheic Dermatitis?
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What is the characteristic of a skin lesion that is described as 'confluent'?
What is the characteristic of a skin lesion that is described as 'confluent'?
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Which of the following is NOT a characteristic used to describe the texture of a skin lesion?
Which of the following is NOT a characteristic used to describe the texture of a skin lesion?
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Which of the following medications is NOT typically used to treat acne vulgaris?
Which of the following medications is NOT typically used to treat acne vulgaris?
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Which of the following statements about pemphigus is FALSE?
Which of the following statements about pemphigus is FALSE?
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What is the most common factor that contributes to hidradenitis suppurativa (HS)?
What is the most common factor that contributes to hidradenitis suppurativa (HS)?
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What is the primary characteristic required for a diagnosis of acne vulgaris?
What is the primary characteristic required for a diagnosis of acne vulgaris?
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What is the primary function of topical retinoids in acne vulgaris treatment?
What is the primary function of topical retinoids in acne vulgaris treatment?
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Which of the following is a common treatment option for chronic low-grade hidradenitis suppurativa?
Which of the following is a common treatment option for chronic low-grade hidradenitis suppurativa?
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Which of the following is a common treatment for moderate acne vulgaris?
Which of the following is a common treatment for moderate acne vulgaris?
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What is the clinical characteristic that often indicates the presence of a sinus tract in hidradenitis suppurativa?
What is the clinical characteristic that often indicates the presence of a sinus tract in hidradenitis suppurativa?
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What is the most common age for spontaneous remission of hidradenitis suppurativa?
What is the most common age for spontaneous remission of hidradenitis suppurativa?
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Which of the following statements regarding factors affecting the severity of acne vulgaris is TRUE?
Which of the following statements regarding factors affecting the severity of acne vulgaris is TRUE?
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Which of the following is a characteristic of bullous pemphigoid?
Which of the following is a characteristic of bullous pemphigoid?
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What is a common feature of hidradenitis suppurativa that might contribute to psychological distress?
What is a common feature of hidradenitis suppurativa that might contribute to psychological distress?
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What is the primary difference between pemphigus and bullous pemphigoid?
What is the primary difference between pemphigus and bullous pemphigoid?
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Which of the following medications is most commonly used to treat both mild and moderate acne vulgaris?
Which of the following medications is most commonly used to treat both mild and moderate acne vulgaris?
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What is the most likely underlying cause of the inflammatory response seen in acne vulgaris?
What is the most likely underlying cause of the inflammatory response seen in acne vulgaris?
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What are the two possible arrangement types of lesions?
What are the two possible arrangement types of lesions?
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Which characteristic is assessed through palpation?
Which characteristic is assessed through palpation?
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Which characteristic describes the degree of clarity in the border of a lesion?
Which characteristic describes the degree of clarity in the border of a lesion?
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What are the two primary considerations when assessing the location and distribution of a lesion?
What are the two primary considerations when assessing the location and distribution of a lesion?
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Which of the following is NOT assessed when palpating a lesion?
Which of the following is NOT assessed when palpating a lesion?
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What are the key aspects of the 'Type' characteristic of a lesion?
What are the key aspects of the 'Type' characteristic of a lesion?
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What does 'Confluence' refer to regarding skin lesions?
What does 'Confluence' refer to regarding skin lesions?
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Which of the following is NOT a characteristic of skin lesions described in the provided content?
Which of the following is NOT a characteristic of skin lesions described in the provided content?
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Flashcards
Papulo-squamous diseases
Papulo-squamous diseases
Skin disorders characterized by papules and plaques such as dermatitis, eczema, and psoriasis.
Desquamation
Desquamation
The shedding of the outer skin layer, which includes conditions like erythema multiforme and toxic epidermal necrolysis.
Vesicular bullae
Vesicular bullae
A type of skin lesion with fluid-filled blisters, includes pemphigoid and pemphigus.
Acneiform lesions
Acneiform lesions
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Primary skin lesions
Primary skin lesions
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Secondary skin lesions
Secondary skin lesions
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Cell differentiation
Cell differentiation
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Keratinization
Keratinization
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Color
Color
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Location/distribution
Location/distribution
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Arrangement
Arrangement
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Margination
Margination
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Palpation
Palpation
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Shape
Shape
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Type
Type
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Single vs multiple
Single vs multiple
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Lichen Simplex Chronicus
Lichen Simplex Chronicus
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Numular Eczema
Numular Eczema
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Contact Dermatitis
Contact Dermatitis
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Stasis Dermatitis
Stasis Dermatitis
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Atopic Dermatitis
Atopic Dermatitis
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Seborrheic Dermatitis
Seborrheic Dermatitis
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Treatment for Lichen Simplex Chronicus
Treatment for Lichen Simplex Chronicus
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Symptoms of Contact Dermatitis
Symptoms of Contact Dermatitis
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Atopic Dermatitis Triggers
Atopic Dermatitis Triggers
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Common Sites for Seborrheic Dermatitis
Common Sites for Seborrheic Dermatitis
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Cradle Cap
Cradle Cap
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Perioral Dermatitis
Perioral Dermatitis
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Fixed Drug Eruption
Fixed Drug Eruption
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Lichen Planus
Lichen Planus
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Pityriasis Rosea
Pityriasis Rosea
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Psoriasis
Psoriasis
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Guttate Psoriasis
Guttate Psoriasis
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Common Treatments
Common Treatments
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Pruritus
Pruritus
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Hidradenitis Suppurativa
Hidradenitis Suppurativa
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Lesion Types
Lesion Types
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Pathogenesis of Hidradenitis
Pathogenesis of Hidradenitis
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Clinical Features of Hidradenitis
Clinical Features of Hidradenitis
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Treatment Options
Treatment Options
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Skin Lesion Description
Skin Lesion Description
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Effective Scarring
Effective Scarring
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Sinus Tracts
Sinus Tracts
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Pemphigus
Pemphigus
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Bullous Pemphigoid
Bullous Pemphigoid
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Nikolsky sign
Nikolsky sign
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Acne Vulgaris
Acne Vulgaris
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Comedones
Comedones
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Treatment for mild acne
Treatment for mild acne
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Moderate Acne Treatment
Moderate Acne Treatment
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Factors in Acne Pathogenesis
Factors in Acne Pathogenesis
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Acne Scars
Acne Scars
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Acne Severity in Ethnicities
Acne Severity in Ethnicities
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Study Notes
Dermatology 1
- Topics covered include papulo-squamous diseases (dermatitis, eczema, drug eruptions, lichen planus, pityriasis rosea, psoriasis), desquamation (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), vesicular bullae (pemphigoid, pemphigus), and acneiform lesions (acne vulgaris, rosacea, folliculitis).
Instructional Objectives
- Identify and describe the etiology, epidemiology, clinical features, differential diagnosis, and management of various skin disorders.
- Accurately describe skin lesions using standard terms.
Skin Lesions: Standard Terms
- Number: single, multiple
- Pigmentation/color: white, flesh colored, pink, pearly, erythematous, tan-brown, salmon, black, purple, violaceous, and yellow.
- Shape & Arrangement: annular, round/discoid, linear, oval, iris/target, zosteriform, serpiginous, stellate, reticulate, morbilliform, polycyclic.
- Texture: consistency, mobility, temperature, tenderness, depth
- Borders/margins: well-defined, ill-defined.
- Type: primary (macule, tumor, patch, wheal, papule, vesicle, plaque, bulla, nodule, pustule, cyst, telangiectasia) and secondary (crust, fissure, scale, ulcer, lichenified, keloid, erosion, hypertrophic scar, atrophy, excoriation).
- Arrangement/location/distribution: localized, regional, generalized.
- Associated Changes: to be documented.
Skin Layers
- Epidermis
- Dermis
- Subcutaneous tissue (fat)
Epidermal Layers
- Stratum corneum
- Granular layer
- Spinous layer
- Basal layer
- Keratohyaline granules
- Desmosomes
Skin Cell Formation
- 4 steps: cell division (basal layer), cell differentiation, keratinization, desquamation.
- Keratinocytes divide in the basal layer; as they move up, they change shape and composition.
- Keratinocytes secrete keratin proteins and lipids to form a matrix protecting the skin.
- Outermost skin cells die and shed.
Dermis
- Contains hair follicles, nerve endings, sweat glands, and connective tissue.
Skin Exam
- Be thorough! Examine the patient in a gown.
- Use good lighting (consider magnification).
- Check scalp, palms, soles, and nails.
- Look for lesions that appear different from others.
- Note skin texture, turgor, and color.
- Document findings in detail/photograph and monitor for changes over time.
- Take a picture and compare to another picture in 6 months or 1 year.
Approach to Diagnosis (CLAMPS TN)
- Color
- Location/distribution (extent, pattern)
- Arrangement (grouped vs. disseminated & confluence)
- Margination (well- or ill-defined)
- Palpation (consistency, temperature, mobility, tenderness, depth)
- Shape
- Type (papule, macule, pustule)
- Number (single vs. multiple)
Types of Skin Lesions (images)
- Crust
- Cyst
- Macule
- Papule
- Pustule
- Ulcer
- Vesicle
- Wheal
Macule
- Non-palpable
- <1 cm diameter
- Varied pigmentation from surrounding skin.
- No elevation or depression.
- Patch: macule >1 cm diameter
Papule
- Palpable
- ≤1 cm diameter (isolated or grouped).
- Pustule: small, circumscribed papule containing purulent material.
Pustule
- Circumscribed superficial cavity with purulent exudate.
- Exudate: white, yellow, greenish-yellow, or hemorrhagic.
Plaque
- Plateau-like elevation.
- Ex: psoriasis, lichenification, patch-flat, or barely elevated plaque (atopic dermatitis/eczema).
Nodule
- Palpable, solid, fatty, or cystic, round or ellipsoidal.
- Larger than a papule (1-2 cm)
- Think of it as a large papule.
- Tumor: nodule >2 cm.
Wheal
- Irregularly shaped, elevated, edematous.
- Erythematous or paler than surrounding skin.
- Well-demarcated borders, but not stable.
- Disappears within 24-48 hours.
- Multiple wheals/rash = urticaria (hives, whelps)
Vesicle/Bulla
- Blister
- Vesicle <0.5 cm
- Bulla >0.5cm
- Well-defined
- Roof is thin
- Serum and blood.
Secondary Skin Lesions
- Crust-dried serum, blood, or exudate.
- Scales-flakes
- Erosion-epidermis defect (heals without scar).
- Excoriation.
- Ulcer - defect deeper into dermis (usually indented).
- Scar-fibrous tissue replacement.
- Atrophy-diminution of some or all layers of skin.
Keloid Scars
- Illustration of keloid scars
Describing Skin Lesions (format)
- Systematic approach/format (CLAMPS TN):
- Color
- Location/distribution (extent, pattern)
- Arrangement (grouped vs. disseminated & confluence)
- Margination (well- or ill-defined)
- Palpation (consistency, temperature, mobility, tenderness, depth)
- Shape
- Type (e.g., papule, macule, pustule)
- Number (single vs. multiple)
History
- Demographics (age, race, sex, occupation, hobbies, chemical/toxin exposure)
- Constitutional symptoms (acute vs. chronic)
- History of skin lesions (OLD CARTS)
- HPI (History of Present Illness)
- PMHx (Past Medical History)
- FHx (Family History) – skin cancer/disorders
- SocHx (Social History)
- SexHx (Sexual History)
HX of Skin Lesion (OLD CARTS)
- 8 Key Questions
- When did lesion appear (1st noticed)?
- Where did lesion appear (site of onset)?
- Does it come and go or is it constant?
- Does it itch, hurt, or bleed?
- How has it spread (pattern/evolution)?
- How have individual lesions changed?
- What are provocative factors?
- What are previous treatments (topical, systemic)?
Desquamation
- Erythema multiforme
- Stevens-Johnson Syndrome (SJS)
- Toxic Epidermal Necrolysis (TEN)
Erythema Multiforme
- Presentation: 50% are <20 y/o, M=F.
- Cutaneous reaction (drugs, idiopathic), most commonly due to herpes simplex virus (HSV).
- Target lesions (mucous involvement, palms/soles, cornea, anterior uveitis), pruritis, or burning.
- Typical target-like lesions.
- Major: drug reaction, mucosa involvement (pharynx & larynx).
- Minor: lesions on extremities & face.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
- Acute, life-threatening mucocutaneous reactions
- Necrosis & detachment of epidermis.
- SJS <10% detachment, TEN >30% detachment (overlap 10-30%).
- 90% involvement of mucous membranes—ocular, oral, genital.
- Rarely present on palms/soles.
- Idiopathic or drug-induced (anti-seizure meds, sulfa, allopurinol, NSAIDs).
- Increased incidence in HIV & active cancer, F > M.
Nikolsky sign
- Ability to extend superficial sloughing by applying gentle lateral pressure elsewhere on skin.
- Pathognomonic for pemphigus and TEN.
Vesiculobullous Disease
- Bullous pemphigoid: autoimmune, elderly patients, large, tense bullae, often starts with urticarial eruption. Common in axillae, medial thigh, groin, flexor UE, lower LE, can be in mouth. Tx - PO, topical steroids 50-100mg QD or immunosuppressives.
- Pemphigus: chronic or acute, bullous, autoimmune, adults 40-60, predilection for scalp, face, chest, axillae, groin, umbilicus, usually starts in mouth, painful vesicles & bullae that rupture easily, flaccid, weeping, + Nikolsky sign. Tx - dermatologist, high dose steroids and immunosuppression.
Acne & Related Disorders
- Acne vulgaris
- Rosacea
- Hidradenitis suppurativa
Acne Vulgaris
- Inflammation of pilosebaceous units.
- Seen with comedones (must have), cysts, pustules, and/or nodules.
- Primarily in young people on face, trunk, upper arms, sometimes buttocks.
- Can result in pits, depressions, scars, or hyperpigmentation.
- More severe in males than females.
- Less common in Asians & African Americans.
- Cystic acne can be familial.
Acne Vulgaris (cont'd)
- Factors in pathogenesis: follicular keratinization, androgens, Propionibacterium acnes (bacteria).
- Follicular plugging (comedones) traps sebum, androgens produce more sebum, bacteria produce inflammation.
- Contributory factors: meds (lithium, isoniazid, steroids, OCPs), androgens, stress, occlusion/pressure, cosmetics, pomade, sweat.
- Worse in fall/winter, painful nodulo-cystic type.
- Comedones (open=blackheads, closed=whiteheads) for diagnosis.
- Labs-none required
- Course-often clears by early 20s, flares in winter and with menarche.
Acne Vulgaris (treatment)
- Treatment (mild): topical antibiotics (clindamycin, erythromycin) and benzoyl peroxide gels.
- Topical retinoids (gradual increase in strength from 0.01% to 0.05%, cream, gel, liquid, or ointment).
- Adapalene (now OTC), and tazarotene - do not use during pregnancy.
- Combination therapy best.
Acne Vulgaris (treatment cont'd)
- Treatment (moderate): same mild regimen plus PO antibiotics (minocycline, doxycycline) tapered to 50mg daily if improves. Spironolactone 25-50mg QD.
Acne Vulgaris (treatment cont'd)
- Treatment (severe): same regimen, plus PO isotretinoin for cystic or refractory acne.
Acne Vulgaris (isotretinoin)
- Complete remission in most cases.
- Works by inhibiting sebaceous gland function and keratinization.
- Extremely teratogenic, MUST have effective contraception and 2 negative pregnancy tests prior to use.
- Use caution, check lipids & transaminases and normalize doses.
- Can cause extremely dry skin and mucosa. and depression.
Rosacea
- Chronic inflammation of facial pilosebaceous units
- 30-50 years old, F>M
- Episodic erythema ("flushing and blushing").
- Stages I, II, and III: persistent erythema, telangiectasias, papules, tiny pustules, nodules.
- Note: no comedones.
- Triggered by hot liquids, spicy foods, alcohol/wine, aged cheese, sun, heat, stress
- Duration: days, weeks, or months
Rosacea (cont'd)
- Late stages: rhinophyma, metophyma, blepharophyma, otophyma, gnatophyma.
- Distribution: symmetric on the face; rarely on neck, chest, back, scalp.
- Recurrences are common, usually lifelong.
- Treatment:
- Reduce alcohol and caffeine.
- Metronidazole gel or cream, ivermectin cream
- Topical antibiotics
- PO antibiotics (minocycline, doxycycline, tetracycline) for papulopustular rosacea.
- PO isotretinoin for severe disease
- Surgery for rhinophyma, telangiectasia (lasers).
Folliculitis
- Inflammation or infection of superficial hair follicles.
- Perifollicular papules &/or pustules with surrounding erythema, hair-bearing skin, often pruritic.
- More common in males.
- Risk factors: prolonged antibiotic use, topical corticosteroids, hot tubs, (most common staph aureus, hot tubs → Pseudomonas aeruginosa).
Folliculitis (treatment)
- Treatment: benzoyl peroxide wash, topical mupirocin, clindamycin, erythromycin. If no improvement, PO Cephalexin.
Hidradenitis Suppurativa
- Chronic, suppurative.
- Apocrine gland skin (axillae, inguinocrural, anogenital, inframammary, rarely scalp.)
- F (axillae) > M (anogenital).
- FHx NC acne & HS.
- Unknown etiology.
- Risk factors: obesity, smoking, genetic predisposition to acne.
Hidradenitis Suppurativa (cont'd)
- Lesions: tender, open & double comedones; red nodules, abscesses, sinus tracts; "bridge" scars; hypertrophic & keloidal scars; contractures.
- Pathogenesis: follicle plugging, dilated follicle & apocrine duct > inflammation, bacterial growth > extension of suppuration/tissue destruction > ulceration, fibrosis, sinus tracts > scarring.
Hidradenitis Suppurativa (treatment)
- Usual spontaneous remission at >35 years.
- Treatment: intralesional steroids, I&D abscess, prednisone for severe pain & inflammation, surgery (excision, skin grafting), PO antibiotics (chronic low-grade disease), isotretinoin for early disease, adalimumab (Humira), Psychological support.
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Description
Test your knowledge about skin lesions and their characteristics with this comprehensive quiz. From primary to secondary lesions, explore treatment options and features relevant to various skin disorders. Perfect for medical students and professionals looking to refresh their expertise in dermatology.