Depressive Disorders and Symptoms
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Questions and Answers

Which side effect is common (greater than 30% frequency) for Venlafaxine?

  • Somnolence
  • Dry mouth
  • Nausea (correct)
  • Headaches
  • What is the recommended dose range for Citalopram?

  • 20–40 mg (correct)
  • 100–300 mg
  • 10–20 mg
  • 50–200 mg
  • Which antidepressant has the highest recommended dose range?

  • Bupropion (correct)
  • Moclobemide
  • Fluoxetine
  • Duloxetine
  • Which side effect is specifically associated with Fluvoxamine?

    <p>Tremor</p> Signup and view all the answers

    What is a common side effect of Paroxetine?

    <p>Nausea</p> Signup and view all the answers

    Which of the following medications is not routinely available in the United States?

    <p>Agomelatine</p> Signup and view all the answers

    What is the common side effect frequency for Male sexual dysfunction in SSRIs?

    <p>None</p> Signup and view all the answers

    Which SNRI has a dose range that starts at 75 mg?

    <p>Venlafaxine</p> Signup and view all the answers

    What is a side effect seen with Bupropion?

    <p>Insomnia</p> Signup and view all the answers

    Which medication has a higher incidence of nausea than any other side effects?

    <p>Desvenlafaxine</p> Signup and view all the answers

    What is a key factor in determining the initial treatment for a major depressive disorder?

    <p>Duration of depressive episodes</p> Signup and view all the answers

    What percentage of outpatients with uncomplicated, nonchronic major depressive disorder typically respond to medication?

    <p>45-60%</p> Signup and view all the answers

    What is the recommended duration for maintaining antidepressant treatment?

    <p>At least 6 months or the length of the previous episode</p> Signup and view all the answers

    What should be done when discontinuing antidepressant treatment?

    <p>Taper the drug dose gradually over 1 to 2 weeks</p> Signup and view all the answers

    Which group of patients is typically considered for maintenance treatment?

    <p>Patients with recurrent or chronic depressions</p> Signup and view all the answers

    What is a potential indication for prophylactic treatment in depressive patients?

    <p>Episodes with significant suicidal ideation</p> Signup and view all the answers

    Which treatment is effective for patients suffering from seasonal winter depression?

    <p>Light Therapy</p> Signup and view all the answers

    Which type of antidepressants may provide greater efficacy in treating melancholic depressions?

    <p>Antidepressants with dual action on serotonergic and noradrenergic receptors</p> Signup and view all the answers

    What is the primary purpose of repetitive transcranial magnetic stimulation (rTMS)?

    <p>To provide focal electrical stimulation to targeted cortical regions.</p> Signup and view all the answers

    What is one of the most common side effects associated with rTMS treatment?

    <p>Scalp pain or discomfort.</p> Signup and view all the answers

    During what time of day is phototherapy typically administered?

    <p>Before dawn or after dusk.</p> Signup and view all the answers

    What demographic primarily represents patients with seasonal affective disorder (SAD)?

    <p>Women representing at least 75 percent of patients.</p> Signup and view all the answers

    Which condition is NOT a significant indication for phototherapy?

    <p>Chronic fatigue syndrome.</p> Signup and view all the answers

    What is the light intensity range typically used in phototherapy?

    <p>1,500 to 10,000 lux or more.</p> Signup and view all the answers

    Which statement is true regarding the use of light visors for phototherapy?

    <p>They allow mobility but have uncertain efficacy based on recent studies.</p> Signup and view all the answers

    What potential risk does phototherapy pose on rare occasions?

    <p>Switching patients into mania or hypomania.</p> Signup and view all the answers

    Which disorder has the highest rate of progression from dysthymia?

    <p>Major depressive disorder</p> Signup and view all the answers

    What is a common correlation of depression in older persons?

    <p>Loss of a spouse</p> Signup and view all the answers

    What percentage of patients with dysthymia never attain complete recovery?

    <p>25 percent</p> Signup and view all the answers

    Which of these factors contributes to the underdiagnosis of depression in older adults?

    <p>Common somatic complaints</p> Signup and view all the answers

    What is the prognosis for patients with major depressive disorder after their first hospitalization?

    <p>50 percent will recover in the first year</p> Signup and view all the answers

    What is the primary feature of major depressive disorder?

    <p>Occurrence of at least one major depression episode</p> Signup and view all the answers

    Which of these treatments is noted to have positive effects on the prognosis of dysthymia?

    <p>Cognitive and behavior therapies</p> Signup and view all the answers

    Which type of psychotic symptoms is aligned with the mood disorder in major depressive disorder?

    <p>Mood-congruent psychotic symptoms</p> Signup and view all the answers

    What happens to the severity of depressive episodes as a patient experiences more episodes?

    <p>The severity increases</p> Signup and view all the answers

    What are melancholic features associated with in terms of depressive disorders?

    <p>Historical concepts about mood</p> Signup and view all the answers

    What is the likelihood of recurrence for patients after two years of leaving the hospital?

    <p>30 to 50 percent</p> Signup and view all the answers

    What percentage range of older persons is reported to experience depression?

    <p>25 to almost 50 percent</p> Signup and view all the answers

    What characterizes the relapse rate among patients on prophylactic psychopharmacological treatment?

    <p>Lower incidence of relapse</p> Signup and view all the answers

    Why might clinicians undersell depressive symptoms in older patients?

    <p>Assumptions of normal aging processes</p> Signup and view all the answers

    What percentage of major depressive disorder patients experience a recurrence within five years?

    <p>50 to 75 percent</p> Signup and view all the answers

    Which condition is typically an indicator of a poor prognosis in major depressive disorder?

    <p>Presence of psychotic features</p> Signup and view all the answers

    What is a primary characteristic of melancholia?

    <p>Profound feelings of guilt over trivial events</p> Signup and view all the answers

    How many symptoms are required for a diagnosis of Major Depressive Disorder?

    <p>5</p> Signup and view all the answers

    What distinguishes melancholic features in Major Depressive Disorder?

    <p>Loss of pleasure or reactivity to pleasure</p> Signup and view all the answers

    Which of the following is not a symptom of Major Depressive Disorder?

    <p>Increased libido</p> Signup and view all the answers

    What is often noted about the timing of symptoms in melancholia?

    <p>Symptoms tend to worsen in the morning</p> Signup and view all the answers

    Which of the following is a characteristic of atypical features in depression?

    <p>Mood reactivity</p> Signup and view all the answers

    What type of depression is melancholia sometimes referred to as?

    <p>Endogenous depression</p> Signup and view all the answers

    Which of the following exclusions would not lead to a Major Depressive Disorder diagnosis?

    <p>Adjustment disorder</p> Signup and view all the answers

    In which scenario would psychotic features be present during Major Depressive Disorder?

    <p>Only during the depressive episode</p> Signup and view all the answers

    Which symptom is associated with an increased chance of suicidal ideation in melancholic depression?

    <p>Feelings of worthlessness</p> Signup and view all the answers

    What is a common psychosocial consequence of Major Depressive Disorder?

    <p>Distressed functioning in social areas</p> Signup and view all the answers

    Which duration is typically necessary for the symptoms to be considered for a Major Depressive Disorder diagnosis?

    <p>2 weeks</p> Signup and view all the answers

    Which of the following is not considered a symptom of Major Depressive Disorder in the DSM-5?

    <p>Increased sexual desire</p> Signup and view all the answers

    Which treatment may be noted for patients who demonstrate melancholic features?

    <p>Electroconvulsive Therapy</p> Signup and view all the answers

    Study Notes

    Depressive Disorders

    • A depressed mood and a loss of interest or pleasure are key symptoms of depression. These symptoms often manifest in various aspects of a person's life, affecting their daily functioning and overall well-being. Many individuals may find it challenging to engage in activities that previously brought them joy, leading to a significant decline in life satisfaction.
    • Patients may describe feeling blue, hopeless, or worthless, as distinct from normal sadness or grief. This distinction is crucial, as these feelings are more pervasive and can last for extended periods, sometimes months or even years, rather than subsiding with time as typical sadness would.
    • Depression can present as agonizing emotional pain, exhaustion, or a lack of motivation. Some patients report an inability to cry or experience pleasure. This emotional distress can be coupled with physical symptoms, further complicating the individual's ability to cope and maintain their day-to-day activities.
    • Classic presentation: stooped posture, decreased movement, downward gaze. These physical manifestations are often evident in individuals suffering from depression and can particularly influence how they are perceived by others.
    • Psychomotor retardation: observable decreased spontaneous movement. This can include slower reactions, reluctance to engage in physical activities, and a noticeable reduction in facial expressions.
    • Catatonia: a severe form of psychomotor retardation that may be difficult to differentiate from other conditions. This state may manifest as lack of response to external stimuli, rigid posture, and a significant decrease in verbal communication.
    • Ms. A, a 34-year-old literature professor, presented with a lack of direction, purpose, and inability to assert herself, with thoughts halted. Her case exemplifies how depression can affect individuals deeply, altering their identity and capabilities in both personal and professional realms.

    Neurovegetative Symptoms

    • Reduced energy, difficulty finishing tasks, and reduced motivation are common complaints. As a result, individuals often struggle to meet personal and professional obligations, leading to increased stress and relationship difficulties.
    • Difficulty sleeping, especially early morning awakening (terminal insomnia) and multiple awakenings at night, are common. These sleep disturbances can exacerbate feelings of fatigue and dissatisfaction, creating a vicious cycle that perpetuates depressive symptoms.
    • Decreased appetite and weight loss is common, but some experience increased appetite and weight gain and longer sleep than usual. This may be called reversed neurovegetative symptoms or atypical features. These differing patterns of appetite and sleep can make diagnosis challenging, as they present a wide range of symptoms that may not fit classic models of depression.
    • Neurovegetative symptoms present a variety of physical symptoms which are essential in the diagnostic process, listed in Table 7.1. Understanding these symptoms is critical for identifying the severity of the disorder and tailoring appropriate treatment options.
    • Many depressed patients have a decreased rate and volume of speech and delayed responses, and observable symptoms are helpful, but lack of symptoms does not negate a disorder. Recognizing that depression can manifest in various ways emphasizes the need for comprehensive assessment during diagnosis.
    • The most typical somatic symptoms of depression are characterized as neurovegetative symptoms. These encompass physical signs that can be assessed objectively, providing a clearer picture of the disorder's impact on the individual's health.

    Dysphoria and Anhedonia

    • Dysphoria: encompasses various subjective depressive feelings such as sadness, depression, or feeling blue. It serves as a broad term that encapsulates the emotional landscape of those suffering from depression.
    • Anhedonia: describes the inability to experience pleasure from normally enjoyable activities. This symptom is particularly significant, as it underscores the profound impact of depression on an individual's ability to engage in life and derive satisfaction from everyday moments.

    Suicide Risk

    • Two-thirds of depressed patients contemplate suicide, and 10-15% commit suicide. These alarming statistics highlight the critical importance of early intervention and support for individuals experiencing severe depressive episodes.
    • Recently hospitalized patients with suicide attempts have a higher risk of future suicide. This necessitates ongoing monitoring and comprehensive mental health care for those who have previously faced acute suicidal ideation, as they are among the most vulnerable populations.

    Cognitive Impairment

    • The majority (50-75%) of depressed patients experience cognitive impairment, which includes problems with concentration and thinking. This cognitive dysfunction can significantly hinder an individual's ability to perform daily tasks and participate fully in their lives.
    • Subtle memory difficulties may also occur as part of the cognitive impairment. These memory issues can interfere with both short-term and long-term memory, making it difficult for individuals to recall important information or events.

    Depression in Special Populations

    • Children/adolescents: may present with school phobia, excessive clinging, poor academic performance, substance abuse, antisocial behavior, sexual promiscuity, truancy, and running away. These presentations highlight the complex nature of depression in younger populations, which may not always align with traditional markers of the disorder.
    • Older adults: prevalence is higher than in the general population and commonly co-occurs with other illnesses, often with somatic (physical) rather than emotional complaints. This can lead to underdiagnosis and undertreatment, as their depressive symptoms may be mistaken for side effects of comorbid conditions.

    Major Depressive Disorder (MDD) and Diagnosing Criteria

    • One or more major depressive episodes. Notably, these episodes can vary in intensity and duration, impacting overall functioning and quality of life.
    • Criteria in Table 7-2, comparing DSM-5 and ICD-10 systems. Understanding the specific criteria required for diagnosis is essential for proper treatment planning and facilitating appropriate care pathways for affected individuals.

    Depression With Psychotic Features

    • Mood-congruent delusions/hallucinations that are consistent with depressed mood. These symptoms reflect the pervasive nature of depressive states that can distort reality, making it crucial to address them in a therapeutic context.
    • Mood-incongruent delusions/hallucinations not consistent with depressed mood. Such features indicate a more complex psychiatric condition that necessitates careful management and intervention strategies.

    Depression With Melancholic Features

    • Includes characteristics like severe anhedonia, early morning awakening, weight loss, and profound feelings of guilt. These features are indicative of a more severe form of depression, often requiring more intensive treatment approaches to address the depth of suffering experienced.

    Dysthymic Disorder (persistent depressive disorder)

    • Depressive symptoms less severe than major depressive disorder. Despite being less intense, these symptoms can persist for years, affecting an individual’s overall functioning and happiness.
    • Chronically depressed mood most of the day for at least two years. Dysthymia can be insidious, as individuals may become accustomed to their low mood, complicating diagnosis and treatment. This condition is also listed in both DSM-5 and ICD-10, ensuring that healthcare professionals use standardized criteria for diagnosis and treatment planning.

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    Depressive Disorders PDF

    Description

    Explore the key symptoms and presentations of depressive disorders, including emotional pain, psychomotor retardation, and neurovegetative symptoms. This quiz delves into the experiences of patients, such as feelings of hopelessness and lack of motivation, as well as the impact on daily functioning.

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