Depression and Pain Management Treatments
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Questions and Answers

Match the following antidepressants with their corresponding effects:

Duloxetine = Treats chronic neuropathic pain Venlafaxine = Targets serotonin and norepinephrine reuptake Desvenlafaxine = Active metabolite of Venlafaxine Selegiline = Transdermal patch for patients unresponsive to SSRIs and TCAs

Match the following pain management drugs with their properties:

Morphine = Pure agonist targeting Mu receptors Naloxone = Used to reverse overdose; pure antagonist Buprenorphine = Partial mu agonist with limited respiratory depression Fentanyl = Mu antagonist

Match the following sleep-related substances with their mechanisms:

Ramelton = Melatonin agonist Suvorexant = Orexin receptor antagonist Caffeine = Adenosine receptor antagonist Barbiturates = Suppress REM sleep

Match the following psychedelics with their characteristics:

<p>Scopolamine = Anticholinergic used for sedation LSD = Causes visual and auditory distortion MDMA = Enhances communication and empathy Mescaline = Chemically similar to dopamine</p> Signup and view all the answers

Match the following substances with their uses in addiction treatment:

<p>Naloxone = Heroin antagonist Methadone = Heroin agonist Varenicline = Partial nicotine agonist Disulfiram = Alcohol aversive treatment</p> Signup and view all the answers

Match the following opioid substances with their characteristics:

<p>Suboxone = Buprenorphine + Naloxone combination Pentazocine = Weak Mu antagonist + Kappa agonist Tramadol = Mixed agonist Gabapentin = Decreases nociceptor excitation</p> Signup and view all the answers

Match the following substances related to cannabis with their functions:

<p>Rimonabant = Cannabinoid antagonist; suppresses appetite Carboxy THC = Identifies THC in urine tests THC = Psychoactive component of cannabis CBD = Non-psychoactive compound in cannabis</p> Signup and view all the answers

Match the following medications used in alcohol withdrawal treatment:

<p>Diazepam = Prevents withdrawal seizures Naltrexone = Prevents relapse Disulfiram = Prolongs unpleasant effects of alcohol Lamotrigine = Anticonvulsant for mood stabilization</p> Signup and view all the answers

Study Notes

Depression Treatments

  • Duloxetine treats chronic neuropathic pain. Its active metabolite is desvenlafaxine.
  • Selegiline, a transdermal patch, is effective in patients unresponsive to SSRIs and TCAs.
  • Venlafaxine targets serotonin and norepinephrine reuptake.

Pain and Opioids

  • Morphine targets Mu receptors and is a pure agonist.
  • Naloxone reverses opioid overdose; a pure antagonist.
  • Buprenorphine limits respiratory depression and abuse potential, acting as a partial Mu agonist.
  • Suboxone combines Buprenorphine and Naloxone.
  • Pentazocine is an analgesic with dysphoric effects; a weak Mu antagonist and Kappa agonist.
  • Fentanyl is a Mu antagonist.
  • Tramadol is a mixed agonist.
  • Laudanum is a mixture of alcohol and opioids.

Pain Management (Non-Opioid)

  • Aspirin and other NSAIDs decrease inflammation.
  • Gabapentin and Pregabalin decrease nociceptor excitation.
  • Opioids decrease neurotransmitter release by nociceptors.
  • Antidepressants and opioids activate anti-pain pathways.
  • Opioids influence cognitive and emotional processing.

Sleep Medications

  • Ramelteon is a melatonin agonist.
  • Suvorexant is an orexin receptor antagonist.
  • Caffeine is an adenosine receptor antagonist.
  • Barbiturates and alcohol suppress REM sleep.
  • Z-drugs (Zaleplon, Zolpidem, Eszopiclone) are short- to mid-acting sleep aids.

Psychedelics

  • Scopolamine is an anticholinergic used for sedation and twilight anesthesia.
  • Psilocybin, found in mushrooms, is chemically similar to serotonin.
  • MDMA enhances communication and empathy.
  • LSD causes visual, auditory, and space/time distortions.
  • Mescaline is chemically similar to dopamine and norepinephrine.

Cannabis Treatment

  • Rimonabant is a cannabinoid antagonist that suppresses appetite.
  • Carboxy THC is used in urine tests to detect THC.

Alcohol Treatment

  • Diazepam prevents withdrawal seizures.
  • Disulfiram prolongs the unpleasant effects of alcohol to deter relapse.
  • Naltrexone prevents relapse.
  • Lamotrigine is an anticonvulsant.

Addiction Treatment

  • Naloxone is a heroin antagonist.
  • Methadone is a heroin agonist.
  • Nicotine patches are a cigarette alternative.
  • Varenicline (Chantix) is a partial nicotine agonist.
  • Disulfiram (Antabuse) is an alcohol aversive treatment.
  • Suboxone is an aversive treatment for opioids.

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Description

Explore the various treatments for depression and pain management, focusing on both opioid and non-opioid options. Learn about the mechanisms of drugs like Duloxetine, Morphine, and NSAIDs, and their effectiveness in clinical settings. This quiz provides insight into the crucial aspects of pharmacology related to mental health and pain relief.

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