Antidepressants and Depression Treatment

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Questions and Answers

Which type of 5HT receptors is responsible for the therapeutic effects of SSRIs?

  • 5HT1A (correct)
  • 5HT3 and 5HT4
  • 5HT6 and 5HT7
  • 5HT2A and 5HT2C

What is the primary factor in selecting an antidepressant drug?

  • Indication for the medication (correct)
  • Availability of the medication
  • Cost of the medication
  • Potential drug interactions

What is the most common adverse effect of SSRIs?

  • Nausea (correct)
  • Loss of libido
  • Anorgasmia
  • Weight gain

Which of the following conditions is NOT typically treated with antipsychotic drugs?

<p>Nonpsychotic anxiety disorder (B)</p> Signup and view all the answers

What is the primary mechanism of action of SSRIs?

<p>Agonist action on 5HT1A receptors (B)</p> Signup and view all the answers

What is the primary route of excretion for SSRIs?

<p>Renal (B)</p> Signup and view all the answers

What is the primary goal of using antidepressant drugs in the treatment of depression?

<p>To alleviate the symptoms of depression (A)</p> Signup and view all the answers

Which type of antidepressant is chemically diverse and specifically inhibits serotonin reuptake?

<p>Selective serotonin reuptake inhibitors (SSRIs) (A)</p> Signup and view all the answers

What is a common adverse effect of tricyclic antidepressants (TCAs) due to the block of muscarinic receptors?

<p>Dry mouth (C)</p> Signup and view all the answers

What is the mechanism by which tricyclic antidepressants (TCAs) increase the concentration of monoamines in the synaptic cleft?

<p>By inhibiting the reuptake of serotonin and norepinephrine (B)</p> Signup and view all the answers

How do tricyclic antidepressants (TCAs) compare to selective serotonin reuptake inhibitors (SSRIs) in terms of safety in overdose?

<p>SSRIs are safer in overdose than TCAs (B)</p> Signup and view all the answers

What is the primary route of excretion for tricyclic antidepressants (TCAs)?

<p>Renal (D)</p> Signup and view all the answers

What is the estimated percentage of the population affected by schizophrenia?

<p>1% (A)</p> Signup and view all the answers

What is the primary goal of pharmacological treatment of psychoses?

<p>To eliminate the symptoms of the disease (D)</p> Signup and view all the answers

What is the term for the disruption to normal emotions and behaviors in schizophrenia?

<p>Negative symptoms (B)</p> Signup and view all the answers

What is the neurochemical basis of positive symptoms in schizophrenia?

<p>Overactivity of mesolimbic dopamine receptors (B)</p> Signup and view all the answers

What is the term for the classification of antipsychotic drugs that are first-generation?

<p>Typical (D)</p> Signup and view all the answers

What is the approximate age range when schizophrenia most commonly has its onset?

<p>Late adolescence to early adulthood (A)</p> Signup and view all the answers

Which type of antipsychotic drugs are known to ameliorate both positive and negative symptoms of schizophrenia?

<p>Atypical antipsychotic drugs (A)</p> Signup and view all the answers

What is the primary mechanism of action of antipsychotic drugs in reducing symptoms of schizophrenia?

<p>Blocking of D2 dopamine receptors (D)</p> Signup and view all the answers

Which of the following side effects is commonly associated with conventional antipsychotic drugs?

<p>Extrapyramidal side effects (D)</p> Signup and view all the answers

What is the primary difference between typical and atypical antipsychotic drugs?

<p>Side effect profile (D)</p> Signup and view all the answers

Which of the following is a long-term side effect of conventional antipsychotic drugs?

<p>Tardive dyskinesias (A)</p> Signup and view all the answers

What is the reason for the endocrine side effects of antipsychotic drugs?

<p>Increased prolactin release (A)</p> Signup and view all the answers

What is the primary consideration for choosing an antipsychotic drug?

<p>Differences in adverse effects and efficacy (B)</p> Signup and view all the answers

Which of the following antipsychotic drugs is known to cause bone marrow suppression?

<p>Clozapine (C)</p> Signup and view all the answers

What is the approximate percentage of patients who do not respond to antipsychotic drugs?

<p>20% (B)</p> Signup and view all the answers

How do slow-release preparations of antipsychotic drugs work?

<p>They act for a longer duration, typically 2-4 weeks (A)</p> Signup and view all the answers

What is the primary route of administration for antipsychotic drugs?

<p>Oral administration (B)</p> Signup and view all the answers

What is the main organ responsible for the metabolism of antipsychotic drugs?

<p>Liver (C)</p> Signup and view all the answers

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