The Monoamine Hypothesis and Antidepressants Quiz
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Questions and Answers

Which neurotransmitters are believed to be functionally deficient in depression according to the monoamine hypothesis?

  • Noradrenaline and dopamine
  • Serotonin and GABA
  • Noradrenaline and serotonin (correct)
  • Dopamine and serotonin

    • How do antidepressants improve the mood of the patient?

  • By increasing dopamine levels
  • By blocking the reuptake of monoamines (correct)
  • By inhibiting the breakdown of monoamines
  • By decreasing serotonin and noradrenaline levels

    • Which class of antidepressants primarily block the reuptake of serotonin?

  • Tricyclic antidepressants (TCAs)
  • Monoamine oxidase inhibitors (MAOIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • Selective serotonin reuptake inhibitors (SSRIs) (correct)

    • Which class of antidepressants block the reuptake of both serotonin and noradrenaline?

    <p>Serotonin-norepinephrine reuptake inhibitors (SNRIs)</p> Signup and view all the answers

    How do monoamine oxidase inhibitors (MAOIs) affect serotonin and noradrenaline?

    <p>By preventing their breakdown</p> Signup and view all the answers

    Select the correct statement on selective serotonin reuptake inhibitor (SSRI)

    <p>It crosses the blood-brain barrier</p> Signup and view all the answers

    Select the correct statement on tricyclic antidepressant (TCA)

    <p>It can be metabolized by liver cytochrome CYP2D6 enzymes</p> Signup and view all the answers

    Select the correct statement about side effects of an antidepressant

    <p>TCA causes sedating effect by blocking histamine H1 receptors</p> Signup and view all the answers

    Select the correct statement on clinical use of antidepressant

    <p>A suicidal ideation or indication should be closely monitored within first to second weeks of antidepressant regime</p> Signup and view all the answers

    Select the suitable antidepressant for a patient that moderately depressed but has a history of heart attack (last year)

    <p>SSRI</p> Signup and view all the answers

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