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Dengue Virus and Disease Overview

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30 Questions

What is the typical incubation period for dengue?

5-7 days

What is the main reason for the resurgence of dengue in the 1980s?

All of the above

What percentage of dengue infections are symptomatic?

25%

Which clinical classification did the WHO replace in 2009?

Dengue and Dengue Hemorrhagic Fever/Dengue Shock Syndrome

What is the duration of the febrile phase in dengue?

2-7 days

Which of the following is NOT a contributing factor to the resurgence of dengue?

Improved public health infrastructure

What is the main way that dengue viruses are spread to people?

Through the bite of an infected Aedes mosquito

What percentage of the world's population lives in areas at risk of dengue?

50%

What is the estimated number of deaths from severe dengue each year?

40,000

How many different dengue virus serotypes are there?

4

Which of the following statements about the release of dengue virus is most accurate?

Some dengue virus is released as fully mature membrane protein and can reinfect other cells, while some is released with immature membrane protein and cannot infect other cells.

When were the first reported epidemics of dengue?

1779-1780

What is a common laboratory finding in dengue fever during the acute phase?

Thrombocytopenia

Which diagnostic test would be most appropriate for detecting dengue virus in the acute phase (≤7 days after symptom onset)?

Dengue virus antigen detection (NS1)

What is a common symptom during the convalescent phase of dengue fever?

Itchy, flaking rash

Which of the following specimen types would be appropriate for molecular testing (RT-PCR) for dengue virus?

Serum

What is a common hemodynamic change observed as a patient's well-being improves during dengue fever?

Bradycardia

Which of the following laboratory findings is NOT commonly associated with dengue fever?

Hypocalcemia

What is the recommended treatment for fever in dengue patients?

Acetaminophen and tepid sponge baths

Why should dengue patients avoid mosquito bites?

To reduce the risk of further transmission

What is the recommended treatment for fluid loss due to capillary leakage in dengue patients?

Intravenous fluids and monitoring hematocrit levels

What is the reason why prophylactic platelet transfusions are not recommended for dengue patients?

They can contribute to fluid overload

What is the key difference between the two dengue vaccines mentioned in the text?

DengVaxia requires 3 doses, while QDenga requires 2 doses.

What is the key caution regarding the use of the DengVaxia vaccine?

It may increase the risk of severe dengue if administered to seronegative individuals.

What is the main purpose of Nucleic Acid Amplification Testing (NAAT) for dengue?

Confirm dengue infection

Which statement about Dengue Virus Antigen Detection using NS1 is accurate?

NS1 is secreted into the blood during dengue infection

In Dengue diagnosis, what is the role of IgM antibody testing when used alongside NAAT or NS1 detection?

Confirms dengue infection

Why is Tissue testing for dengue virus not considered an immediate diagnostic tool?

It requires a biopsy or autopsy specimen

Which statement about IgM Antibody ELISA in Dengue diagnosis is correct?

It can cross-react with other unrelated viruses

Why is there no specific antiviral treatment for dengue?

Because of the rapid mutation rate of the DENV serotypes

Learn about the Dengue virus and the disease it causes. Understand how the virus spreads through infected mosquito bites and its effects on the human body. Explore the different forms in which the virus can be released and its impact on cellular infection and vascular leakage.

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