Immunology BE433 Prof Christine Loscher Lecture 3: Innate Immunity Quiz

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Which of the following is true about the complement system?

It marks pathogens for destruction by phagocytes (correct)
It only activates in specific tissues of the body
It directly destroys pathogens by lysing them
It inhibits the recruitment of phagocytes to the site of infection

What is the function of some complement protein fragments?

Inhibit the activation of phagocytes
Trigger a decrease in the inflammatory response
Prevent the binding of complement proteins to pathogens
Act as chemoattractants to recruit more phagocytes (correct)

How are complement proteins activated at sites of infection?

They remain inactive and do not participate in the immune response
They are activated locally and trigger a series of inflammatory events (correct)
They are only activated in the presence of specific antibodies
They are activated systemically and have a general anti-inflammatory effect

What happens to complement proteins at the start of the pathway?

The activation of a small number of complement proteins is hugely amplified by each successive reaction (A) Signup and view all the answers

What triggers the activation of complement proteins?

Cleavage of zymogen (A) Signup and view all the answers

What is the role of complement proteins in phagocytosis?

They bind covalently to pathogens, opsonizing them for phagocytosis (B) Signup and view all the answers

How are complement proteins distributed throughout the body?

Widely distributed throughout body fluids and tissues without effect (C) Signup and view all the answers

What is the consequence of complement protein activation?

Triggering a series of inflammatory events (D) Signup and view all the answers

How are complement proteins regulated?

Very tightly regulated (B) Signup and view all the answers

What is the role of the complement system in interacting with pathogens?

Marking them for destruction by phagocytes (A) Signup and view all the answers

Which of the following is true about the terminal complement components?

They damage certain bacteria by creating pores in the bacterial membrane (B) Signup and view all the answers

What is the main function of small fragments of complement?

Stimulate increased blood flow, vascular permeability, and adherence of phagocytes to endothelial cells (C) Signup and view all the answers

Which receptor is best characterized for mediating the ingestion of complement-tagged pathogens by phagocytes?

CR1 (B) Signup and view all the answers

What is the main function of chemokines?

Induce directed chemotaxis in nearby responsive cells (C) Signup and view all the answers

What is the role of complement in the immune response?

Enables the engulfing of bacteria and the recruitment of cells to the site of infection (D) Signup and view all the answers

Which proteins are lacking on pathogen surfaces, allowing the action of C3 in the complement system?

Regulatory proteins such as DAF, CD55, factor 1, factor H (D) Signup and view all the answers

What happens when the terminal complement proteins polymerize in the complement system?

They form pores in membranes that can kill certain pathogens (B) Signup and view all the answers

Which of the following is a function of cytokines?

They induce responses through binding specific receptors on target cells (B) Signup and view all the answers

What is the main function of chemoattractant cytokines (chemokines)?

Induce directed chemotaxis in nearby responsive cells (C) Signup and view all the answers

Which of the following is true about complement activation?

It is largely confined to the surface on which it is initiated (B) Signup and view all the answers

Which of the following is a function of the terminal complement proteins?

Polymerize to form pores in membranes that can kill certain pathogens (A) Signup and view all the answers

What is the main function of chemoattractant cytokines (chemokines)?

Induce directed chemotaxis in nearby responsive cells (A) Signup and view all the answers

What is the role of complement proteins in phagocytosis?

Mediate the ingestion of complement-tagged pathogens by phagocytes (D) Signup and view all the answers

What triggers the activation of complement proteins?

Pathogen surfaces lacking regulatory proteins (B) Signup and view all the answers

What is the consequence of complement protein activation?

Formation of pores in membranes that can kill certain pathogens (D) Signup and view all the answers

What is the main function of small fragments of complement?

Stimulate increased blood flow, vascular permeability, and adherence of phagocytes to endothelial cells (C) Signup and view all the answers

How are complement proteins regulated?

Host cells have regulatory proteins such as DAF, CD55, factor 1, and factor H (C) Signup and view all the answers

What happens when the terminal complement proteins polymerize in the complement system?

Formation of the membrane attack complex (MAC) to kill certain pathogens (C) Signup and view all the answers

What is the role of the complement system in interacting with pathogens?

Enables the engulfing of bacteria and recruitment of cells to the site of infection (B) Signup and view all the answers

Which receptor is best characterized for mediating the ingestion of complement-tagged pathogens by phagocytes?

CR1 (D) Signup and view all the answers

Immunology BE433 Prof Christine Loscher Lecture 3: Innate Immunity Quiz

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Questions and Answers

Which of the following is true about the complement system?

What is the function of some complement protein fragments?

How are complement proteins activated at sites of infection?

What happens to complement proteins at the start of the pathway?

What triggers the activation of complement proteins?

What is the role of complement proteins in phagocytosis?

How are complement proteins distributed throughout the body?

What is the consequence of complement protein activation?

How are complement proteins regulated?

What is the role of the complement system in interacting with pathogens?

Which of the following is true about the terminal complement components?

What is the main function of small fragments of complement?

Which receptor is best characterized for mediating the ingestion of complement-tagged pathogens by phagocytes?

What is the main function of chemokines?

What is the role of complement in the immune response?

Which proteins are lacking on pathogen surfaces, allowing the action of C3 in the complement system?

What happens when the terminal complement proteins polymerize in the complement system?

Which of the following is a function of cytokines?

What is the main function of chemoattractant cytokines (chemokines)?

Which of the following is true about complement activation?

Which of the following is a function of the terminal complement proteins?

What is the main function of chemoattractant cytokines (chemokines)?

What is the role of complement proteins in phagocytosis?

What triggers the activation of complement proteins?

What is the consequence of complement protein activation?

What is the main function of small fragments of complement?

How are complement proteins regulated?

What happens when the terminal complement proteins polymerize in the complement system?

What is the role of the complement system in interacting with pathogens?

Which receptor is best characterized for mediating the ingestion of complement-tagged pathogens by phagocytes?

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