Lecture 32 – Oxidative Phosphorylation
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Questions and Answers

Where does oxidative phosphorylation occur?

  • Cytoplasm
  • Nucleus
  • Mitochondria (correct)
  • Endoplasmic Reticulum
  • What is the primary function of oxidative phosphorylation?

  • Transfer of electrons to oxygen
  • Synthesis of fatty acids
  • ATP production from glucose (correct)
  • Conversion of pyruvate to acetyl-CoA
  • Which cofactors are primarily involved in oxidative phosphorylation?

  • NADH and NADPH
  • FADH2 and NADH (correct)
  • ATP and ADP
  • Coenzyme A and ATP
  • What is the role of the glycerol phosphate shuttle?

    <p>To convert cytoplasmic NADH to FADH2</p> Signup and view all the answers

    What is the net result of the malate shuttle?

    <p>Transfer of electrons from NADH to ubiquinone</p> Signup and view all the answers

    Which antiporter is responsible for importing ADP and Pi into the mitochondrial matrix?

    <p>ATP-ADP antiporter</p> Signup and view all the answers

    What is the main function of the respiratory complexes?

    <p>To pump protons into the intermembrane space</p> Signup and view all the answers

    What happens at Complex I of the electron transport chain?

    <p>Electrons are transferred to ubiquinone</p> Signup and view all the answers

    What is the role of cytochrome c in the electron transport chain?

    <p>It transfers electrons from Complex III to Complex IV.</p> Signup and view all the answers

    How many protons are pumped across the membrane by Complex III?

    <p>4</p> Signup and view all the answers

    Which complex directly links the TCA cycle to the electron transport chain?

    <p>Complex II</p> Signup and view all the answers

    What is the final electron acceptor in the electron transport chain?

    <p>Oxygen</p> Signup and view all the answers

    What is produced as a byproduct of electron transfer to oxygen?

    <p>Water</p> Signup and view all the answers

    What mechanism describes the generation of ATP in oxidative phosphorylation?

    <p>Oxidative phosphorylation</p> Signup and view all the answers

    How many protons are required to synthesize one molecule of ATP?

    <p>3</p> Signup and view all the answers

    What concept did Peter Mitchell propose in 1961?

    <p>The chemiosmotic theory</p> Signup and view all the answers

    What is the purpose of the proton-motive force?

    <p>To create a concentration gradient for ATP synthesis</p> Signup and view all the answers

    What is the role of Complex V (ATP synthase) in oxidative phosphorylation?

    <p>It synthesizes ATP from ADP and Pi.</p> Signup and view all the answers

    Which of the following statements about Complex II is true?

    <p>It is directly linked to the TCA cycle.</p> Signup and view all the answers

    What is the function of thermogenin in brown fat cells?

    <p>Heat generation</p> Signup and view all the answers

    What condition leads to the formation of reactive oxygen species?

    <p>Inefficient electron transfer</p> Signup and view all the answers

    What occurs during the Q cycle in Complex III?

    <p>Two electrons are transferred to one electron carrier.</p> Signup and view all the answers

    How does ADP influence oxidative phosphorylation?

    <p>It promotes electron transfer.</p> Signup and view all the answers

    In the electron transport chain, which complex is responsible for the reduction of oxygen?

    <p>Complex IV</p> Signup and view all the answers

    Which of the following correctly describes the function of F1 in ATP synthase?

    <p>It is the catalytic site for ATP synthesis.</p> Signup and view all the answers

    What would happen if Complex IV is inhibited?

    <p>NADH would accumulate.</p> Signup and view all the answers

    What is a characteristic of super-complexes in the electron transport chain?

    <p>They increase the efficiency of electron transfer.</p> Signup and view all the answers

    What is the primary source of electrons for Complex I?

    <p>NADH</p> Signup and view all the answers

    In the context of oxidative phosphorylation, which molecule is considered a natural uncoupler?

    <p>Thermogenin</p> Signup and view all the answers

    What is the main product of the entire process of oxidative phosphorylation?

    <p>ATP</p> Signup and view all the answers

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