Lecture 32 – Oxidative Phosphorylation

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Questions and Answers

Where does oxidative phosphorylation occur?

  • Cytoplasm
  • Nucleus
  • Mitochondria (correct)
  • Endoplasmic Reticulum

What is the primary function of oxidative phosphorylation?

  • Transfer of electrons to oxygen
  • Synthesis of fatty acids
  • ATP production from glucose (correct)
  • Conversion of pyruvate to acetyl-CoA

Which cofactors are primarily involved in oxidative phosphorylation?

  • NADH and NADPH
  • FADH2 and NADH (correct)
  • ATP and ADP
  • Coenzyme A and ATP

What is the role of the glycerol phosphate shuttle?

<p>To convert cytoplasmic NADH to FADH2 (B)</p> Signup and view all the answers

What is the net result of the malate shuttle?

<p>Transfer of electrons from NADH to ubiquinone (B)</p> Signup and view all the answers

Which antiporter is responsible for importing ADP and Pi into the mitochondrial matrix?

<p>ATP-ADP antiporter (A)</p> Signup and view all the answers

What is the main function of the respiratory complexes?

<p>To pump protons into the intermembrane space (B)</p> Signup and view all the answers

What happens at Complex I of the electron transport chain?

<p>Electrons are transferred to ubiquinone (B)</p> Signup and view all the answers

What is the role of cytochrome c in the electron transport chain?

<p>It transfers electrons from Complex III to Complex IV. (B)</p> Signup and view all the answers

How many protons are pumped across the membrane by Complex III?

<p>4 (B)</p> Signup and view all the answers

Which complex directly links the TCA cycle to the electron transport chain?

<p>Complex II (B)</p> Signup and view all the answers

What is the final electron acceptor in the electron transport chain?

<p>Oxygen (D)</p> Signup and view all the answers

What is produced as a byproduct of electron transfer to oxygen?

<p>Water (B)</p> Signup and view all the answers

What mechanism describes the generation of ATP in oxidative phosphorylation?

<p>Oxidative phosphorylation (B)</p> Signup and view all the answers

How many protons are required to synthesize one molecule of ATP?

<p>3 (C)</p> Signup and view all the answers

What concept did Peter Mitchell propose in 1961?

<p>The chemiosmotic theory (B)</p> Signup and view all the answers

What is the purpose of the proton-motive force?

<p>To create a concentration gradient for ATP synthesis (B)</p> Signup and view all the answers

What is the role of Complex V (ATP synthase) in oxidative phosphorylation?

<p>It synthesizes ATP from ADP and Pi. (B)</p> Signup and view all the answers

Which of the following statements about Complex II is true?

<p>It is directly linked to the TCA cycle. (B)</p> Signup and view all the answers

What is the function of thermogenin in brown fat cells?

<p>Heat generation (B)</p> Signup and view all the answers

What condition leads to the formation of reactive oxygen species?

<p>Inefficient electron transfer (B)</p> Signup and view all the answers

What occurs during the Q cycle in Complex III?

<p>Two electrons are transferred to one electron carrier. (A)</p> Signup and view all the answers

How does ADP influence oxidative phosphorylation?

<p>It promotes electron transfer. (B)</p> Signup and view all the answers

In the electron transport chain, which complex is responsible for the reduction of oxygen?

<p>Complex IV (D)</p> Signup and view all the answers

Which of the following correctly describes the function of F1 in ATP synthase?

<p>It is the catalytic site for ATP synthesis. (C)</p> Signup and view all the answers

What would happen if Complex IV is inhibited?

<p>NADH would accumulate. (A)</p> Signup and view all the answers

What is a characteristic of super-complexes in the electron transport chain?

<p>They increase the efficiency of electron transfer. (A)</p> Signup and view all the answers

What is the primary source of electrons for Complex I?

<p>NADH (B)</p> Signup and view all the answers

In the context of oxidative phosphorylation, which molecule is considered a natural uncoupler?

<p>Thermogenin (C)</p> Signup and view all the answers

What is the main product of the entire process of oxidative phosphorylation?

<p>ATP (C)</p> Signup and view all the answers

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