Podcast
Questions and Answers
Which transcription factor is specifically activated by IL-4?
Which transcription factor is specifically activated by IL-4?
Which combination of cytokines is responsible for the activation of TH1 cells?
Which combination of cytokines is responsible for the activation of TH1 cells?
What is the function of the transcription factor STAT3 in T helper cell differentiation?
What is the function of the transcription factor STAT3 in T helper cell differentiation?
Which T helper cell subset is induced by the cytokines TGF-β and IL-10?
Which T helper cell subset is induced by the cytokines TGF-β and IL-10?
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If STAT5 is activated, which T helper cell subset will likely differentiate?
If STAT5 is activated, which T helper cell subset will likely differentiate?
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Which cytokine is incorrectly paired with its associated T helper cell subset?
Which cytokine is incorrectly paired with its associated T helper cell subset?
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What role do cytokines play in T helper cell differentiation?
What role do cytokines play in T helper cell differentiation?
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Which transcription factor is responsible for mediating the effects of IL-6?
Which transcription factor is responsible for mediating the effects of IL-6?
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Which of the following combinations would most likely lead to a TH2 response?
Which of the following combinations would most likely lead to a TH2 response?
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The differentiation of which T helper cells is most affected by a lack of IL-21?
The differentiation of which T helper cells is most affected by a lack of IL-21?
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Study Notes
Fate-specifying Cytokines
- Cytokines influence the differentiation of T cells into specific types.
- IFN-γ and IL-12 lead to the development of TH1 cells.
- IL-4, IL-5, and IL-13 promote TH2 cell formation.
- IL-17 and IL-22 drive TH17 cell development.
- IL-21 fosters TFH cell differentiation.
- TGF-β and IL-10 result in iTreg cell development.
- STAT proteins are transcription factors crucial in these pathways.
- Specific transcription factors like T-bet, GATA-3, RORyt, Bcl-6, and FoxP3 are also essential in these processes.
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Description
This quiz explores the role of cytokines in the differentiation of T cells into various subtypes such as TH1, TH2, TH17, and iTreg cells. It covers key cytokines like IFN-γ, IL-4, and their associated transcription factors. Test your knowledge on the complex signaling pathways that shape immune responses!
