Cyclic Antidepressants Toxicity and Management
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Questions and Answers

When should vasopressors be used in the treatment of barbiturate overdose?

  • Only if patients do not respond to IV fluids (correct)
  • Immediately upon presentation to the emergency department
  • In all patients with hemodynamic instability
  • In patients with a history of hypertension
  • What is the primary goal of treatment in cases of barbiturate overdose?

  • Administration of flumazenil to reverse CNS depression
  • Decontamination with gastric lavage
  • Maintenance of adequate airway, respiratory support, and prevention of aspiration (correct)
  • Hemodynamic instability with volume contraction
  • What is the benefit of multiple-dose activated charcoal (MDAC) in the treatment of barbiturate overdose?

  • It induces vomiting
  • It provides respiratory support
  • It increases the absorption of phenobarbital
  • It increases the elimination of phenobarbital (correct)
  • What is the role of activated charcoal in the treatment of barbiturate overdose?

    <p>To enhance elimination of the toxic substance</p> Signup and view all the answers

    Why is gastric lavage considered in patients who overdose with drugs that slow GI motility or may develop concretions?

    <p>To prevent concretions from forming in the GI tract</p> Signup and view all the answers

    What is the contraindication of using flumazenil in cases of unknown overdose?

    <p>All of the above</p> Signup and view all the answers

    What is the effect of alkalinization of the urine on the elimination of phenobarbital?

    <p>It increases the urinary elimination of phenobarbital</p> Signup and view all the answers

    What is the primary mechanism of action of flumazenil?

    <p>It is a competitive benzodiazepine receptor antagonist</p> Signup and view all the answers

    What is the effect of flumazenil on the respiratory depression induced by intravenous benzodiazepines?

    <p>It has no effect on the respiratory depression</p> Signup and view all the answers

    What is the indication for using flumazenil in the treatment of barbiturate overdose?

    <p>There is no specific indication for using flumazenil</p> Signup and view all the answers

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