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Cyclic Antidepressants Toxicity and Management

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Cyclic Antidepressants Toxicity and Management

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Questions and Answers

When should vasopressors be used in the treatment of barbiturate overdose?

Only if patients do not respond to IV fluids (correct)
Immediately upon presentation to the emergency department
In all patients with hemodynamic instability
In patients with a history of hypertension

What is the primary goal of treatment in cases of barbiturate overdose?

Administration of flumazenil to reverse CNS depression
Decontamination with gastric lavage
Maintenance of adequate airway, respiratory support, and prevention of aspiration (correct)
Hemodynamic instability with volume contraction

What is the benefit of multiple-dose activated charcoal (MDAC) in the treatment of barbiturate overdose?

It induces vomiting
It provides respiratory support
It increases the absorption of phenobarbital
It increases the elimination of phenobarbital (correct)

What is the role of activated charcoal in the treatment of barbiturate overdose?

To enhance elimination of the toxic substance (A) Signup and view all the answers

Why is gastric lavage considered in patients who overdose with drugs that slow GI motility or may develop concretions?

To prevent concretions from forming in the GI tract (C) Signup and view all the answers

What is the contraindication of using flumazenil in cases of unknown overdose?

All of the above (D) Signup and view all the answers

What is the effect of alkalinization of the urine on the elimination of phenobarbital?

It increases the urinary elimination of phenobarbital (C) Signup and view all the answers

What is the primary mechanism of action of flumazenil?

It is a competitive benzodiazepine receptor antagonist (C) Signup and view all the answers

What is the effect of flumazenil on the respiratory depression induced by intravenous benzodiazepines?

It has no effect on the respiratory depression (A) Signup and view all the answers

What is the indication for using flumazenil in the treatment of barbiturate overdose?

There is no specific indication for using flumazenil (B) Signup and view all the answers