32, Adrenocortical Hormone Excess

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Questions and Answers

Which of the following is a characteristic of Cushing syndrome?

  • Hypotension
  • Decreased bone density (correct)
  • Increased muscle mass
  • Peripheral edema

What is a common cause of Cushing syndrome?

  • Long-term treatment with glucocorticoids (correct)
  • Endogenous oversecretion of glucocorticoids
  • Low renin substrate levels
  • Impaired absorption of calcium

What is a test for Cushing syndrome?

  • Blood test for renin levels
  • Evaluation of muscle strength (correct)
  • Measurement of peripheral edema
  • Assessment of bone density

Which hormone is primarily responsible for causing spontaneous Cushing syndrome?

<p>Adrenocorticotropic hormone (ACTH) (B)</p> Signup and view all the answers

What is the main cause of nonendocrine ectopic ACTH production in spontaneous Cushing syndrome?

<p>All of the above (D)</p> Signup and view all the answers

What percentage of spontaneous Cushing syndrome cases are caused by an ACTH-independent process?

<p>10% to 20% (C)</p> Signup and view all the answers

What is the recommended dose of hydrocortisone for patients undergoing unilateral adrenal resection?

<p>100 mg every 24 hours (B)</p> Signup and view all the answers

Which of the following is a characteristic of Cushing syndrome?

<p>Decreased formation of bone matrix (A)</p> Signup and view all the answers

What is a common cause of Cushing syndrome?

<p>Long-term treatment with glucocorticoids (D)</p> Signup and view all the answers

What is a test for Cushing syndrome?

<p>Asking the patient to get up from a chair without using the hands (A)</p> Signup and view all the answers

What is the most common cause of spontaneous Cushing syndrome?

<p>Pituitary microadenoma (D)</p> Signup and view all the answers

What is the recommended treatment for marked hypokalemic alkalosis caused by ectopic ACTH production?

<p>Spironolactone (A)</p> Signup and view all the answers

What is the perioperative morbidity rate associated with bilateral adrenalectomy in patients with Cushing syndrome?

<p>Up to 20% (B)</p> Signup and view all the answers

What is the goal of glucocorticoid replacement therapy in patients given adrenal suppressants?

<p>Complete adrenal suppression (C)</p> Signup and view all the answers

Which of the following is a characteristic of Cushing syndrome?

<p>Centripetal distribution of fat (B)</p> Signup and view all the answers

What is a common symptom of glucocorticoid excess (Cushing syndrome)?

<p>Easy bruising (A)</p> Signup and view all the answers

What is the most common cause of Cushing syndrome?

<p>Administration of glucocorticoids (D)</p> Signup and view all the answers

Which hormone is responsible for causing 65% to 75% of all spontaneous cases of Cushing syndrome?

<p>ACTH (C)</p> Signup and view all the answers

What is the common cause of marked hypokalemic alkalosis in patients with Cushing syndrome?

<p>Aldosterone antagonist spironolactone (D)</p> Signup and view all the answers

What is the recommended dose of hydrocortisone for patients undergoing bilateral adrenal resection?

<p>100 mg every 24 hours intravenously (A)</p> Signup and view all the answers

What is the incidence of pneumothorax in an open adrenal resection approach?

<p>20% (C)</p> Signup and view all the answers

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