Creatinine Formation and Measurement Quiz
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Questions and Answers

What are the four parameters required for calculating estimated glomerular filtration rate (eGFR) using the modification of diet in renal disease (MDRD) formula?

  • Serum creatinine, height, weight, age
  • Urine creatinine, serum creatinine, height, weight
  • Urine creatinine, gender, weight, age
  • Serum creatinine, age, gender, race (correct)

    • Which substance may be measured as an alternative to creatinine for evaluating glomerular filtration rate (GFR)?

  • Plasma urea
  • Cystatin C (correct)
  • Uric acid
  • Potassium

    • Which enzyme allows creatinine to be measured by coupling to a peroxidase reaction?

  • Creatinine deaminase
  • Sarcosine oxidase (correct)
  • Creatine kinase (CK)
  • Glucose-6-phosphate dehydrogenase

    • What is the primary reagent used in the Jaffe method for measuring creatinine?

    <p>Saturated picric acid and sodium hydroxide (NaOH)</p> Signup and view all the answers

    How can interference from other reducing substances be partially eliminated in the Jaffe reaction?

    <p>Measuring the timed rate of product formation</p> Signup and view all the answers

    In which case would estimated GFR derived from plasma creatinine likely give a more accurate measurement compared with plasma cystatin C?

    <p>After renal transplantation</p> Signup and view all the answers

    What is the correct source of creatinine in the body?

    <p>Oxidation of creatine</p> Signup and view all the answers

    Why is creatinine considered a substance of choice to measure endogenous renal clearance?

    <p>The rate of formation per day is independent of body size</p> Signup and view all the answers

    Which statement regarding creatinine is true?

    <p>High serum levels result from reduced glomerular filtration</p> Signup and view all the answers

    What is the correct expression for calculating creatinine clearance?

    <p>Creatinine clearance = U/P × V × 1.73/A</p> Signup and view all the answers

    Which condition is most likely to cause a falsely high creatinine clearance result?

    <p>The patient uses the midstream voiding procedure when collecting his or her urine</p> Signup and view all the answers

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