Corynebacterium Diphtheriae: Characteristics & Prevention
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A public health initiative aims to eradicate diphtheria in a region with historically low vaccination rates. Which intervention strategy would be MOST effective in achieving herd immunity and preventing future outbreaks?

  • Isolating infected individuals and treating them with erythromycin to prevent the spread of the disease through respiratory droplets.
  • Administering penicillin to individuals who test positive for _Corynebacterium diphtheriae_ to reduce the bacterial load and transmission rates.
  • Focusing on improving sanitation and hygiene practices to minimize the transmission of _Corynebacterium diphtheriae_ in the community.
  • Implementing a widespread vaccination campaign using diphtheria toxoid, combined with public education on the importance of booster shots. (correct)

A patient presents with symptoms suggestive of diphtheria, but laboratory confirmation is pending. Which treatment approach should be initiated promptly to mitigate the potential for severe complications?

  • Administer a broad-spectrum antibiotic such as amoxicillin to cover potential secondary bacterial infections in the respiratory tract.
  • Prescribe a short course of corticosteroids to reduce inflammation and alleviate symptoms such as sore throat and difficulty swallowing.
  • Initiate treatment with penicillin or erythromycin and administer diphtheria antitoxin to neutralize the effects of the toxin. (correct)
  • Recommend supportive care measures such as rest, hydration, and over-the-counter pain relievers until a definitive diagnosis is established.

In a scenario where a community experiences an outbreak of diphtheria despite a history of adequate immunization coverage, what factors should be investigated to identify the cause of the outbreak?

  • Assess the genetic diversity of _Corynebacterium diphtheriae_ strains circulating in the community to determine if a new, more virulent strain has emerged.
  • Evaluate the effectiveness of the cold chain management system to ensure that vaccines were stored and transported at appropriate temperatures.
  • Investigate potential lapses in vaccine administration practices, such as improper injection techniques or the use of expired vaccines.
  • All of the above. (correct)

Which characteristic of Corynebacterium diphtheriae is most crucial in differentiating it from other Corynebacterium species in a clinical laboratory setting?

<p>Its production of diphtheria toxin, which causes the severe systemic effects associated with diphtheria. (C)</p> Signup and view all the answers

A research laboratory is investigating novel strategies to combat diphtheria. Which approach would likely offer the most effective long-term solution for preventing diphtheria infections?

<p>Engineering a modified diphtheria toxoid vaccine that elicits a broader and more durable immune response in vaccinated individuals. (C)</p> Signup and view all the answers

Flashcards

Corynebacterium

Rod-shaped, non-spore-forming bacteria, aerobic or facultative anaerobic, includes C. diphtheriae.

C. diphtheriae

The most important species of Corynebacterium, causes diphtheria.

Diphtheria

Infection of the upper respiratory tract causing fever, sore throat, and malaise.

Diphtheria Toxoid

Formaldehyde-inactivated diphtheria toxin, maintains antigenicity, used for immunization.

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Penicillin and Erythromycin

Antibiotics used to treat diphtheria infections.

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Study Notes

  • Corynebacteria are rod-shaped bacteria.
  • They are aerobic or facultative anaerobic.
  • Corynebacteria are non-spore-forming and non-motile.
  • These bacteria are straight or slightly curved.
  • The most important species is C. diphtheriae.
  • C. diphtheriae causes diphtheria.
  • Diphtheria is commonly an infection of the upper respiratory tract.
  • Symptoms include fever, sore throat, and malaise.

Prevention and Control

  • Adequate immunization with diphtheria toxoid is key.
  • Diphtheria toxoid is formaldehyde-inactivated diphtheria toxin.
  • The toxoid remains antigenically intact.
  • Penicillin and erythromycin can be used for treatment.

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Description

Corynebacteria are rod-shaped, non-spore-forming bacteria, with C. diphtheriae being the most notable. It causes diphtheria, an upper respiratory tract infection characterized by fever and sore throat. Prevention relies on immunization with diphtheria toxoid, and treatment involves antibiotics like penicillin and erythromycin.

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