Podcast
Questions and Answers
What is the main mechanism of action of colchicine in treating acute gout?
What is the main mechanism of action of colchicine in treating acute gout?
- Direct analgesic effects on the affected joint
- Inhibition of phagocytic activity by interfering with the function of mitotic spindles in neutrophils (correct)
- Reduction of inflammation through inhibition of prostaglandin synthesis
- Promotion of uric acid excretion by the kidneys
Which of the following is the main reason why colchicine is used less commonly today compared to the past?
Which of the following is the main reason why colchicine is used less commonly today compared to the past?
- It has a low therapeutic index (correct)
- It is more expensive than other treatment options
- It has a higher risk of gastrointestinal side effects
- It is less effective than NSAIDs
Which of the following is true about the approved dosage regimen for colchicine in the treatment of acute gout?
Which of the following is true about the approved dosage regimen for colchicine in the treatment of acute gout?
- The initial dose is 1.2 mg, followed by 0.6 mg 1 hour later (correct)
- The initial dose is 0.6 mg, followed by 0.6 mg 1 hour later
- The initial dose is 1.2 mg, followed by 0.6 mg every 12 hours
- The initial dose is 0.6 mg, followed by 0.6 mg every 24 hours
Which of the following is the most common side effect associated with colchicine use?
Which of the following is the most common side effect associated with colchicine use?
In which patient population should the dosing of colchicine be adjusted?
In which patient population should the dosing of colchicine be adjusted?
Which of the following is the primary reason why colchicine may be preferred over NSAIDs for the treatment of acute gout?
Which of the following is the primary reason why colchicine may be preferred over NSAIDs for the treatment of acute gout?
Which of the following statements about the therapeutic index of colchicine is correct?
Which of the following statements about the therapeutic index of colchicine is correct?
What is the primary reason why colchicine is not considered to be an analgesic?
What is the primary reason why colchicine is not considered to be an analgesic?
Which of the following factors is most likely to influence the decision to use colchicine over NSAIDs for the treatment of acute gout?
Which of the following factors is most likely to influence the decision to use colchicine over NSAIDs for the treatment of acute gout?
What is the recommended timing for starting the prophylactic dosing of colchicine after the initial treatment of an acute gout flare?
What is the recommended timing for starting the prophylactic dosing of colchicine after the initial treatment of an acute gout flare?
