10 Questions
What is the main mechanism of action of colchicine in treating acute gout?
Inhibition of phagocytic activity by interfering with the function of mitotic spindles in neutrophils
Which of the following is the main reason why colchicine is used less commonly today compared to the past?
It has a low therapeutic index
Which of the following is true about the approved dosage regimen for colchicine in the treatment of acute gout?
The initial dose is 1.2 mg, followed by 0.6 mg 1 hour later
Which of the following is the most common side effect associated with colchicine use?
Gastrointestinal side effects
In which patient population should the dosing of colchicine be adjusted?
Patients with severe renal impairment (CrCl < 30 mL/min)
Which of the following is the primary reason why colchicine may be preferred over NSAIDs for the treatment of acute gout?
Colchicine is reserved for patients at risk of NSAID-induced gastropathy
Which of the following statements about the therapeutic index of colchicine is correct?
Colchicine has a low therapeutic index, making it a riskier option for the treatment of acute gout
What is the primary reason why colchicine is not considered to be an analgesic?
Colchicine does not have any direct pain-relieving effects
Which of the following factors is most likely to influence the decision to use colchicine over NSAIDs for the treatment of acute gout?
The patient's risk of NSAID-induced gastropathy
What is the recommended timing for starting the prophylactic dosing of colchicine after the initial treatment of an acute gout flare?
12 hours after the initial treatment
Test your knowledge on dose reductions required when corticosteroids are co-administered with p-glycoprotein or strong CYP3A4 inhibitors. Understand the considerations for using systemic corticosteroids in patients with contraindications to NSAIDs or colchicine, and in cases of polyarticular attacks.
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