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Corticosteroids Co-administration Quiz

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Questions and Answers

What is the main mechanism of action of colchicine in treating acute gout?

Direct analgesic effects on the affected joint

Inhibition of phagocytic activity by interfering with the function of mitotic spindles in neutrophils (correct)

Reduction of inflammation through inhibition of prostaglandin synthesis

Promotion of uric acid excretion by the kidneys

Which of the following is the main reason why colchicine is used less commonly today compared to the past?

It has a low therapeutic index (correct)

It is more expensive than other treatment options

It has a higher risk of gastrointestinal side effects

It is less effective than NSAIDs

Which of the following is true about the approved dosage regimen for colchicine in the treatment of acute gout?

The initial dose is 1.2 mg, followed by 0.6 mg 1 hour later (correct)

The initial dose is 0.6 mg, followed by 0.6 mg 1 hour later

The initial dose is 1.2 mg, followed by 0.6 mg every 12 hours

The initial dose is 0.6 mg, followed by 0.6 mg every 24 hours

Which of the following is the most common side effect associated with colchicine use?

Gastrointestinal side effects Signup and view all the answers

In which patient population should the dosing of colchicine be adjusted?

Patients with severe renal impairment (CrCl < 30 mL/min) Signup and view all the answers

Which of the following is the primary reason why colchicine may be preferred over NSAIDs for the treatment of acute gout?

Colchicine is reserved for patients at risk of NSAID-induced gastropathy Signup and view all the answers

Which of the following statements about the therapeutic index of colchicine is correct?

Colchicine has a low therapeutic index, making it a riskier option for the treatment of acute gout Signup and view all the answers

What is the primary reason why colchicine is not considered to be an analgesic?

Colchicine does not have any direct pain-relieving effects Signup and view all the answers

Which of the following factors is most likely to influence the decision to use colchicine over NSAIDs for the treatment of acute gout?

The patient's risk of NSAID-induced gastropathy Signup and view all the answers

What is the recommended timing for starting the prophylactic dosing of colchicine after the initial treatment of an acute gout flare?

12 hours after the initial treatment Signup and view all the answers