Coronary Heart Disease Overview

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Questions and Answers

What is the first action to take when a patient presents with suspected acute myocardial infarction?

  • Start a beta-blocker
  • Conduct a coronary angiography
  • Provide high-flow oxygen (correct)
  • Administer oral nitrates

Which enzyme is commonly used as a biochemical marker for diagnosing myocardial infarction?

  • Alkaline phosphatase
  • Creatine kinase-MB (CK-MB) (correct)
  • Lactate dehydrogenase (LDH)
  • Aspartate aminotransferase (AST)

What are the common symptoms of myocardial infarction apart from chest pain?

  • Persistent headache and vision changes
  • High fever and chills
  • Nausea and partial paralysis
  • Breathlessness and syncope (correct)

What does the development of a Q wave in an ECG indicate during a myocardial infarction?

<p>Change in ventricular repolarization (A)</p> Signup and view all the answers

Why are serial estimations of cardiac biomarkers important in diagnosing myocardial infarction?

<p>They provide diagnostic value through concentration changes (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic symptom of myocardial infarction?

<p>Swelling in the limbs (C)</p> Signup and view all the answers

What should be considered for patients at moderate or high risk of myocardial infarction?

<p>Coronary angiography for revascularization (A)</p> Signup and view all the answers

If a beta-blocker is contraindicated in the management of myocardial infarction, what alternative medication may be considered?

<p>Calcium channel blocker (D)</p> Signup and view all the answers

What is the primary underlying cause of coronary heart disease?

<p>Atheroma and its complications (B)</p> Signup and view all the answers

Which of the following is defined as myocardial necrosis due to acute occlusion of a coronary artery?

<p>Myocardial infarction (C)</p> Signup and view all the answers

What is the clinical manifestation associated with transient myocardial ischaemia?

<p>Angina pectoris (B)</p> Signup and view all the answers

Which factor can precipitate chronic stable angina?

<p>Heavy exercise (C)</p> Signup and view all the answers

What is a significant characteristic of unstable angina?

<p>Pain that occurs at rest or with minimal exertion (B)</p> Signup and view all the answers

Which of the following is NOT a risk factor commonly associated with coronary heart disease?

<p>Excessive hydration (B)</p> Signup and view all the answers

Which of the following is NOT a component of the management of angina pectoris?

<p>Immediate surgical intervention (B)</p> Signup and view all the answers

What type of alterations are seen in the ECG changes during acute ST-elevation myocardial infarction?

<p>Elevated ST segments (B)</p> Signup and view all the answers

What is the main type of myocardial dysfunction resulting from ischemia or infarction?

<p>Systolic dysfunction (D)</p> Signup and view all the answers

What should patients with stable angina avoid for safety?

<p>Engagement in vigorous exercise after a heavy meal (D)</p> Signup and view all the answers

Which class of drugs is used as anti-anginal treatment?

<p>Nitrates (C)</p> Signup and view all the answers

What type of heart condition is characterized by rapid worsening angina or angina at rest?

<p>Unstable angina (A)</p> Signup and view all the answers

Which medication type is used in both antiplatelet and anticoagulant therapy for acute chest pain management?

<p>Aspirin (D)</p> Signup and view all the answers

What is the primary purpose of serial measurements of biochemical markers in chest pain assessment?

<p>To determine the extent of physical damage (B)</p> Signup and view all the answers

Which of the following surgical options is used for the treatment of ischemic heart disease?

<p>Percutaneous coronary intervention (PCI) (A), Coronary artery bypass graft (CABG) surgery (B)</p> Signup and view all the answers

What lifestyle change is recommended to manage stable angina effectively?

<p>Quit smoking (D)</p> Signup and view all the answers

Which medication is preferable for the initial management of stable angina?

<p>Aspirin 300 mg (preferably chewing) (D)</p> Signup and view all the answers

What is a common complication associated with myocardial infarction?

<p>Ischaemia (B)</p> Signup and view all the answers

Which of the following is NOT part of the management protocol for unstable angina?

<p>Immediate deployment of thrombolytics (A)</p> Signup and view all the answers

Which of the following is a mechanical complication of myocardial infarction?

<p>Mitral regurgitation due to papillary muscle damage (B)</p> Signup and view all the answers

What is the initial measure in the management of acute ST-elevation myocardial infarction?

<p>Reperfusion therapy (D)</p> Signup and view all the answers

Which investigation is useful in diagnosing stable angina?

<p>Stress perfusion scanning (D)</p> Signup and view all the answers

What is the role of clopidogrel in the management of coronary heart disease?

<p>It helps maintain vessel patency (A)</p> Signup and view all the answers

Which of the following is a main characteristic of unstable angina?

<p>Chest pain occurring at rest (C)</p> Signup and view all the answers

Which of the following factors is considered an independent risk factor for coronary heart disease?

<p>Family history (C)</p> Signup and view all the answers

What role does HDL cholesterol have in heart health?

<p>Prevents oxidation of LDL (C)</p> Signup and view all the answers

What condition could potentially decrease oxygen supply to the myocardium?

<p>Decreased duration of diastole (A)</p> Signup and view all the answers

How does obesity contribute to the development of coronary heart disease?

<p>Promotes inflammation (B)</p> Signup and view all the answers

Which of the following is NOT a common precipitating activity for stable angina?

<p>Resting quietly (B)</p> Signup and view all the answers

What is the primary function of triglycerides in relation to heart disease?

<p>They lower HDL cholesterol levels (C)</p> Signup and view all the answers

Which of the following conditions increases myocardial oxygen demand?

<p>Increased myocardial contractility (B)</p> Signup and view all the answers

What is a primary symptom of stable angina?

<p>Chest pain that is induced by stress (A)</p> Signup and view all the answers

Flashcards

Coronary Heart Disease (CHD)

The most common type of heart disease globally, often leading to premature death.

Angina Pectoris

Chest pain caused by temporary lack of oxygen to the heart muscle.

Stable Angina

A condition where angina occurs consistently under certain predictable conditions, like exertion.

Unstable Angina

A more serious form of angina where chest pain occurs unexpectedly and without exertion, even at rest.

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Myocardial Infarction (MI)

Death of heart muscle due to complete blockage of a coronary artery, usually caused by a blood clot.

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Heart Failure

Impairment of heart function due to damage or lack of oxygen.

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Arrhythmia

Abnormal heart rhythms that can be caused by coronary heart disease.

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Sudden Death

Sudden and unexpected death caused by heart problems, often related to MI or arrhythmia.

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LDL (Low-Density Lipoprotein)

A type of cholesterol that carries cholesterol from the liver to the body's cells.

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HDL (High-Density Lipoprotein)

A type of cholesterol that removes excess cholesterol from the bloodstream and returns it to the liver for processing.

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Triglycerides

A type of fat found in the blood. High levels can increase the risk of heart disease.

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Resting ECG

A diagnostic test that measures the electrical activity of the heart while the patient is resting.

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Exercise ECG

A diagnostic test that measures the electrical activity of the heart during exercise.

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Myocardial Perfusion Scanning

A diagnostic test that uses radioactive tracers to assess blood flow to the heart muscle.

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Stress Echocardiography

A diagnostic test that uses ultrasound to assess the heart's structure and function during exercise.

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Coronary Arteriography

A medical procedure in which a thin, flexible tube called a catheter is inserted into an artery in the leg or arm and threaded to the heart. Dye is injected into the coronary arteries, allowing doctors to see the arteries on an X-ray.

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Percutaneous Coronary Intervention (PCI)

A procedure used to open blocked or narrowed coronary arteries. A small balloon is inserted into the artery and inflated to open the blockage, allowing blood to flow more freely.

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Coronary Artery Bypass Graft (CABG)

A surgical procedure that involves grafting a healthy blood vessel from another part of the body onto a coronary artery to bypass a blockage.

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Antiplatelet Therapy

A category of drugs that help to prevent blood clots from forming. These drugs are often used to prevent heart attacks and strokes.

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Lipid-lowering Therapy

A class of drugs that help lower cholesterol levels in the blood. They are often used to prevent heart attacks and strokes.

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Analgesia (opiates)

A medication that reduces pain, often used for pain relief after a heart attack.

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Antiemetic

A medication that prevents or relieves nausea and vomiting. It can be used to manage side effects of other medications.

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Reperfusion

A process that aims to restore blood flow to the heart muscle after a heart attack. It can be done through primary PCI or thrombolysis.

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Ischemia

Another complication after a heart attack, caused by reduced blood supply to the heart muscle.

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Beta-blockers

A type of medication that helps to reduce blood pressure and the workload on the heart. It's often used to prevent complications after a heart attack.

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Nitrates

A type of medication that helps to widen blood vessels, improving blood flow to the heart. It's used to treat angina and reduce chest pain.

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What causes a myocardial infarction?

A thrombus forms at the site of a ruptured or eroded atheromatous plaque in a coronary artery, blocking blood flow and causing heart muscle death.

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What is the cardinal symptom of a myocardial infarction?

Pain that is usually more severe and lasts longer than angina, often described as tightness, heaviness, or constriction in the chest.

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Describe the typical ECG changes seen in a myocardial infarction.

ST elevation is the earliest ECG change, followed by R wave reduction, Q wave development, and T wave inversion.

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What are some biochemical markers used to detect a myocardial infarction?

Creatine kinase (CK) and its cardiospecific isoform CK-MB, as well as troponins T and I, are all elevated in the blood following a heart attack.

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What is the immediate management of a patient with suspected acute myocardial infarction?

Immediate access to medical care, defibrillation facilities, high-flow oxygen, IV access, ECG monitoring, and analgesia are essential for patients with suspected acute MI.

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Where are patients with acute myocardial infarction typically managed?

Patients are usually managed in a dedicated cardiac unit because it allows for specialized expertise, monitoring, and resuscitation facilities.

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What medication options are available for the immediate treatment of acute myocardial infarction?

Calcium channel blockers (verapamil or diltiazem) can be used if a beta-blocker is contraindicated. If pain persists, intravenous nitrates may be needed.

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What procedures may be performed for patients with acute myocardial infarction?

Coronary angiography and revascularization are considered for all patients at moderate or high risk of myocardial infarction.

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Study Notes

Coronary Heart Disease (CHD)

  • CHD is the most common form of heart disease and a leading cause of premature death in certain parts of the world.
  • It's almost always due to atheroma and its complications, particularly thrombosis in the coronary arteries.
  • CHD can manifest in various ways, including stable angina, unstable angina, myocardial infarction, heart failure, arrhythmias, and sudden death.

Stable Angina

  • Ischemia (reduced blood flow) due to fixed atheromatous stenosis (narrowing of the arteries) in one or more coronary arteries.
  • Symptoms are characterized by central chest pain, discomfort, or breathlessness, precipitated by exertion or stress, and promptly relieved by rest.
  • Activities that trigger angina include physical exertion, cold exposure, heavy meals, and intense emotions.

Unstable Angina/Non ST-elevation Myocardial Infarction (NSTEMI)

  • Ischemia is caused by dynamic obstruction of a coronary artery due to plaque rupture with superimposed thrombosis and spasm.
  • Characterized by new-onset severe angina, rapidly worsening angina, angina with minimal exertion or at rest.
  • Differentiated from NSTEMI by the absence of elevated myocardial necrosis markers in the blood.
  • Diagnosis relies on chest pain analysis, 12-lead ECG, and cardiac markers.

Myocardial Infarction (MI)

  • Myocardial necrosis (tissue death) caused by acute occlusion (blocking) of a coronary artery.
  • Occurs due to plaque rupture and thrombus formation.
  • Characterized by severe and prolonged chest pain, potentially in the same sites as angina but usually more severe. Other symptoms can include breathlessness, vomiting, and collapse or syncope.
  • Infarction progresses over several hours making prompt intervention crucial.

ST-Elevation Myocardial Infarction (STEMI)

  • Complete occlusion of the coronary artery.
  • Characterized by typical ECG changes and elevated plasma cardiac markers.

Investigations

  • Stable Angina: Resting ECG, exercise ECG, myocardial perfusion scanning, stress echocardiography, coronary arteriography
  • Unstable Angina/NSTEMI: Similar to stable angina, with additional focus on cardiac markers.
  • STEMI: ECG changes including ST elevation and presence of elevated cardiac markers.

Management

  • Stable Angina: Risk factor modification (blood pressure control, smoking cessation, weight loss, diabetes control), lifestyle modifications, aspirin, lipid-lowering therapy, anti-anginal therapy.
  • Unstable Angina/NSTEMI: Urgent medical stabilization, and angiography.
  • STEMI: Immediate access to medical/paramedical care, defibrillation facilities, bed rest, medication (aspirin, antiplatelets, anticoagulants, beta-blockers, calcium channel blockers).

Other Important Concepts

  • Lipid Profile: Necessary for assessing risk and includes testing of TSCH, HDL, LDL, TG, and VLDL levels.
  • Atherosclerosis: The buildup of plaque within the arteries, which narrows the lumen and reduces blood flow. This is a major contributor to CHD.
  • Myocardial Oxygen Demand: Factors affecting need such as heart rate, blood pressure, and myocardial contraction.
  • Myocardial Oxygen Supply: Factors affecting supply such as duration of diastole and coronary vasomotor tone (how constricted vessels are) which impact blood flow.
  • Drug therapy: (antiplatelet, lipid-lowering, anti-anginal medication including nitrates, Beta-blockers, and Calcium channel blockers) are key aspects of managing CHD.

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