COPD and Emphysema: Pathophysiology

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Questions and Answers

In COPD, parenchyma destruction leads to a reduction in the surface area available for gas exchange. How does this affect oxygen and carbon dioxide levels in the blood?

  • Slight increase in both oxygen and carbon dioxide levels.
  • Decreased oxygen levels and increased carbon dioxide levels. (correct)
  • No change in oxygen or carbon dioxide levels.
  • Increased oxygen levels and decreased carbon dioxide levels.

Small airway collapse contributes to static hyperinflation in COPD. What is the primary mechanism by which small airway collapse leads to this hyperinflation?

  • Gas trapping due to airway obstruction. (correct)
  • Increased elastic lung recoil.
  • Decreased respiratory drive.
  • Increased surface area for gas exchange.

During an acute exacerbation of COPD or asthma, airway obstruction is a key factor in respiratory failure. Which of the following is NOT a direct contributor to airway obstruction?

  • Increased secretions.
  • Bronchospasm.
  • Increased inflammation.
  • Increased elastic lung recoil. (correct)

Increased resistance to airflow in COPD leads to several compensatory mechanisms and physiological changes. Which of the following is a typical consequence of increased resistance to airflow?

<p>Increased respiratory rate and increased expiratory time. (A)</p> Signup and view all the answers

Dynamic hyperinflation (PEEPi) occurs in COPD patients due to gas trapping. What is the primary characteristic of dynamic hyperinflation?

<p>Increased relaxation volume of the respiratory system at the end of a tidal expiration. (B)</p> Signup and view all the answers

Which of the following factors directly contributes to the development of hypoxemia and hypercapnia in COPD?

<p>Airflow limitation. (A)</p> Signup and view all the answers

Static hyperinflation is a common finding in COPD. How does total lung capacity typically change in a patient with static hyperinflation?

<p>Total lung capacity increases. (A)</p> Signup and view all the answers

Which of the following best describes the relationship between increased respiratory drive and respiratory rate (RR) in the context of COPD?

<p>Increased respiratory drive leads to an increased respiratory rate. (A)</p> Signup and view all the answers

In COPD, reduced elastic lung recoil contributes to airflow limitation. What is the primary mechanism by which decreased elastic recoil leads to this airflow limitation?

<p>Reduced support for small airways, promoting collapse. (B)</p> Signup and view all the answers

During an asthma attack, bronchospasm significantly contributes to airway obstruction. How does bronchospasm primarily reduce the 'bronchiole diameter'?

<p>Contraction of smooth muscle surrounding the bronchioles. (C)</p> Signup and view all the answers

Flashcards

Emphysema (COPD)

Lung disease involving destruction of alveoli, decreasing the surface area for gas exchange.

Static Hyperinflation

Increase in the total lung capacity and residual volume of the lungs.

Airway Obstruction

Combination of inflammation, bronchospasm, and secretions that reduce the diameter

Dynamic Hyperinflation/PEEPi

Reduced relaxation volume of the respiratory system at the end of a tidal expiration.

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Decreased Elastic Lung Recoil

Reduced capacity of the lungs to recoil, leading to air trapping.

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Small Airway Collapse

Reduced diameter of small airways in the lungs.

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Resistance to Airflow

Increased resistance to airflow in the lungs

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Hypoxemia/Hypercapnia

A decrease in pO2 and Increase in pCO2

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Study Notes

  • Emphysema (COPD) can cause parenchyma destruction, decreasing the surface area for gas exchange
  • Emphysema (COPD) can also reduce elastic lung recoil, causing small airway collapse
  • Small airway collapse can increase total lung capacity and residual volume which promotes static hyperinflation
  • COPD acute exacerbation/asthma can be caused by an increase in inflammation, bronchospasm, and/or secretions
  • Inflammation, bronchospasm, and secretions can lead to airway obstruction by decreasing bronchiole diameter
  • Airway obstruction increases resistance to airflow
  • Increased resistance to airflow causes airflow limitation
  • Airflow limitation leads to gas trapping, resulting in dynamic hyperinflation (PEEPi)
  • Airflow limitation also causes hypoxemia and hypercapnia, stimulating respiratory drive
  • Increased respiratory drive results in increased respiratory rate (RR), decreased expiratory time, and increased tidal volume

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