18 Questions
What is the primary pathogenic mechanism underlying the development of emphysema?
Destruction of alveolar walls due to elastase activity
Which of the following is a common complication of emphysema in COPD?
Interstitial emphysema
What is the primary cause of alpha-1 antitrypsin deficiency, which can lead to panacinar emphysema?
Variants in the pi (proteinase inhibitor) gene on chromosome 14
Which of the following is a characteristic feature of bronchiectasis?
Production of copious purulent sputum
Which of the following is a common comorbidity associated with emphysema in COPD?
Chronic bronchitis
What is the primary histologic characteristic of chronic bronchitis in COPD?
Increased mucus-secreting goblet cells
What is the histologic characteristic associated with centriacinar emphysema?
Dilatation of respiratory bronchioles
Which type of emphysema is strongly associated with cigarette smoking?
Centriacinar emphysema
What is the clinical presentation specifically associated with chronic bronchitis in COPD?
Chronic cough with excessive mucus production
Which type of emphysema is associated with loss of elasticity and sometimes deficiency of alpha 1 antitrypsin?
Panacinar emphysema
What microscopically distinguishes chronic obstructive pulmonary disease (COPD) III - Emphysema from other types of emphysema?
Alveolar spurs and compressed alveolar capillaries
Which type of emphysema tends to localize subjacent to the pleura and inter-lobar septa?
Para-septal emphysema
Which of the following is a typical histologic characteristic of chronic bronchitis in COPD?
Marked hyperplasia of mucus-secreting submucosal glands
Which of the following is a complication of chronic bronchitis in COPD?
All of the above
Which of the following is NOT a clinical presentation of chronic bronchitis in COPD?
Reduced total vital capacity
Which of the following is a characteristic of emphysema in COPD?
All of the above
Which of the following is a clinico-pathological characteristic of emphysema in COPD?
All of the above
Which of the following is a radiographic finding in emphysema in COPD?
All of the above
Test your knowledge on the pathogenesis of emphysema, which is often a complication of Chronic Obstructive Pulmonary Disease (COPD). Learn about the role of proteolytic enzymes like elastase, alpha-1 antitrypsin, cigarette smoking, and hereditary factors in the development of emphysema.
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