Emphysema Pathogenesis Quiz
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Questions and Answers

What is the primary pathogenic mechanism underlying the development of emphysema?

  • Decreased activity of proteolytic enzymes like elastase
  • Destruction of alveolar walls due to elastase activity (correct)
  • Increased mucus production in the airways
  • Increased production of alpha-1 antitrypsin

    • Which of the following is a common complication of emphysema in COPD?

  • Lung abscess
  • Interstitial emphysema (correct)
  • Interstitial fibrosis
  • Pulmonary edema

    • What is the primary cause of alpha-1 antitrypsin deficiency, which can lead to panacinar emphysema?

  • Variants in the pi (proteinase inhibitor) gene on chromosome 14 (correct)
  • Chronic exposure to cigarette smoke
  • Increased production of proteolytic enzymes
  • Autoimmune destruction of alveolar walls

    • Which of the following is a characteristic feature of bronchiectasis?

    <p>Production of copious purulent sputum</p> Signup and view all the answers

    Which of the following is a common comorbidity associated with emphysema in COPD?

    <p>Chronic bronchitis</p> Signup and view all the answers

    What is the primary histologic characteristic of chronic bronchitis in COPD?

    <p>Increased mucus-secreting goblet cells</p> Signup and view all the answers

    What is the histologic characteristic associated with centriacinar emphysema?

    <p>Dilatation of respiratory bronchioles</p> Signup and view all the answers

    Which type of emphysema is strongly associated with cigarette smoking?

    <p>Centriacinar emphysema</p> Signup and view all the answers

    What is the clinical presentation specifically associated with chronic bronchitis in COPD?

    <p>Chronic cough with excessive mucus production</p> Signup and view all the answers

    Which type of emphysema is associated with loss of elasticity and sometimes deficiency of alpha 1 antitrypsin?

    <p>Panacinar emphysema</p> Signup and view all the answers

    What microscopically distinguishes chronic obstructive pulmonary disease (COPD) III - Emphysema from other types of emphysema?

    <p>Alveolar spurs and compressed alveolar capillaries</p> Signup and view all the answers

    Which type of emphysema tends to localize subjacent to the pleura and inter-lobar septa?

    <p>Para-septal emphysema</p> Signup and view all the answers

    Which of the following is a typical histologic characteristic of chronic bronchitis in COPD?

    <p>Marked hyperplasia of mucus-secreting submucosal glands</p> Signup and view all the answers

    Which of the following is a complication of chronic bronchitis in COPD?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is NOT a clinical presentation of chronic bronchitis in COPD?

    <p>Reduced total vital capacity</p> Signup and view all the answers

    Which of the following is a characteristic of emphysema in COPD?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a clinico-pathological characteristic of emphysema in COPD?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a radiographic finding in emphysema in COPD?

    <p>All of the above</p> Signup and view all the answers

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