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Contact-Dependent Signaling Overview

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Questions and Answers

What is contact-dependent signaling?

Cells communicate without physical contact.

Only one cell is involved.

It involves signaling molecules released into the bloodstream.

Cells must be touching with receptor and signal. (correct)

What is the first step in retina formation?

Unspecified epithelial cells race to make differentiating molecules first

What happens in the second step of retina formation?

The 'winner' expresses signaling molecule Delta on its surface and neighboring cells have NOTCH.

What is the third step in retina formation?

DELTA binds the receptor NOTCH on all neighboring cells. Signup and view all the answers

What does the fourth step in retina formation trigger?

It triggers a signaling pathway in neighboring cells that prevents them from picking the same fate. Signup and view all the answers

What is lateral inhibition?

Preventing neighbors from sharing the same fate. Signup and view all the answers

Study Notes

Contact-Dependent Signaling

Requires direct cell-to-cell contact for communication through receptors and signaling molecules.
Example analogy: Determining roles in a band, such as who becomes the lead singer versus backup singers.

Steps in Retina Formation

First Step: Unspecified epithelial cells compete to produce differentiating molecules, initiating retina development.
Second Step: The "winning" cell expresses the signaling molecule Delta on its surface; surrounding cells possess NOTCH receptors.
Third Step: Delta from the winning cell binds to NOTCH on neighboring cells, facilitating direct communication; both Delta and NOTCH are membrane-bound proteins.
Fourth Step: This interaction activates signaling pathways in neighboring cells, preventing them from adopting the same developmental fate.

Lateral Inhibition

A process where a cell’s fate influences adjacent cells, inhibiting them from following the same developmental pathway.

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Description

Explore the mechanisms of contact-dependent signaling in cellular communication. This quiz covers key concepts such as the steps involved in retina formation and the role of specific signaling molecules. Perfect for students and enthusiasts of cellular biology.