6 Questions
What is the consequence of increased permeability of the mitochondrial membrane?
Leakage of mitochondrial proteins into the cytoplasm inducing apoptosis
How does ischemia lead to an increase in cytosolic calcium levels?
By stimulating release from intracellular stores
What is the role of cytosolic calcium in apoptosis?
Activation of damaging enzymes and caspases
How does an increase in intracellular calcium levels affect mitochondrial function?
Induces loss of mitochondrial membrane potential
Which organelle sequesters most of the cytosolic calcium under normal conditions?
Endoplasmic reticulum
What is the ultimate outcome of increased cytosolic calcium levels due to ischemia?
Promotion of apoptosis
This quiz explores the consequences of mitochondrial damage including depletion of ATP, formation of reactive oxygen species (ROS), formation of mitochondrial permeability transition pore, and leakage of mitochondrial proteins into the cytoplasm. Test your knowledge on these important cellular processes!
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