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Questions and Answers
What is the consequence of increased permeability of the mitochondrial membrane?
What is the consequence of increased permeability of the mitochondrial membrane?
- Decrease in cytosolic calcium levels
- Formation of reactive oxygen species
- Enhanced production of ATP
- Leakage of mitochondrial proteins into the cytoplasm inducing apoptosis (correct)
How does ischemia lead to an increase in cytosolic calcium levels?
How does ischemia lead to an increase in cytosolic calcium levels?
- By reducing phospholipase activity
- By promoting influx of calcium into the mitochondria
- By stimulating release from intracellular stores (correct)
- By decreasing intracellular enzyme activity
What is the role of cytosolic calcium in apoptosis?
What is the role of cytosolic calcium in apoptosis?
- Inhibition of caspase activity
- Prevention of mitochondrial damage
- Promotion of cell proliferation
- Activation of damaging enzymes and caspases (correct)
How does an increase in intracellular calcium levels affect mitochondrial function?
How does an increase in intracellular calcium levels affect mitochondrial function?
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Which organelle sequesters most of the cytosolic calcium under normal conditions?
Which organelle sequesters most of the cytosolic calcium under normal conditions?
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What is the ultimate outcome of increased cytosolic calcium levels due to ischemia?
What is the ultimate outcome of increased cytosolic calcium levels due to ischemia?
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