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Questions and Answers
What is the primary cause of cell death by necrosis in the context of hypoxia and ischemia?
What is the primary cause of cell death by necrosis in the context of hypoxia and ischemia?
- DNA damage caused by radiation and chemotherapeutic agents
- Inflammation caused by pathogens and necrotic cells
- Deficiency of oxygen leading to the failure of energy-dependent metabolic pathways (correct)
- Accumulation of p53 protein triggering apoptosis
What is the main source of cellular ATP production during the reduction of oxygen in the mitochondria?
What is the main source of cellular ATP production during the reduction of oxygen in the mitochondria?
- Protein misfolding
- Inflammatory cell secretion
- DNA damage
- Oxidative phosphorylation (correct)
What is the role of the accumulation of p53 protein in response to DNA damage?
What is the role of the accumulation of p53 protein in response to DNA damage?
- Leads to deficiency of oxygen and failure of metabolic pathways
- Causes inflammation by secreting damaging products
- Arrests cell cycle for DNA repair; triggers apoptosis if damage is too great (correct)
- Depletes essential proteins leading to cell death
What is the consequence of endoplasmic reticulum stress due to protein misfolding?
What is the consequence of endoplasmic reticulum stress due to protein misfolding?
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What are the primary causes of inflammation leading to damage of host tissues?
What are the primary causes of inflammation leading to damage of host tissues?
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