Congestive Heart Failure (CHF) Learning
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Questions and Answers

Which of the following is a source of free intracellular calcium in CHF due to increased sympathetic activity?

  • Decrease in cardiac preload
  • Release of calcium from the sarcoplasmic reticulum and mitochondria (correct)
  • Reduction in systemic arteriolar resistance
  • Dilation of venous blood vessels

Which adverse effect is most commonly associated with ACE inhibitor therapy in CHF?

  • Persistent dry cough (correct)
  • Renal insufficiency
  • Postural hypotension
  • Hyperkalemia

Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

  • Metolazone
  • Hydrochlorothiazide
  • Furosemide (correct)
  • Bumetanide

Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

<p>(hydralazine) (D)</p> Signup and view all the answers

Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

<p>Angiotensin II blockers (B)</p> Signup and view all the answers

Which drug's mechanism of action involves regulation of cytosolic calcium concentration and increased contractility of cardiac muscle?

<p>Cardiac glycosides (Digitalis) (C)</p> Signup and view all the answers

What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

<p>Hyperkalemia (D)</p> Signup and view all the answers

Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

<p>Verapamil (D)</p> Signup and view all the answers

Which inotropic agent leads to an increase in intracellular cAMP, resulting in the activation of protein kinase, phosphorylation of calcium channel, and increased calcium entrance?

<p>Phosphodiesterase inhibitors (C)</p> Signup and view all the answers

What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

<p>Hypokalemia (D)</p> Signup and view all the answers

What is the most commonly used β-Adrenergic agonist other than digitalis for improving cardiac performance in CHF?

<p>Dobutamine (C)</p> Signup and view all the answers

What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

<p>Digoxin therapy along with ACE inhibitors and diuretics (A)</p> Signup and view all the answers

What are the major causes of congestive heart failure (CHF)?

<p>Chronic hypertension, valvular disease, and coronary artery disease (C)</p> Signup and view all the answers

Which class of heart failure is characterized by symptoms occurring at rest?

<p>Class IV (severe) (D)</p> Signup and view all the answers

What is the main symptom of Class III (moderate) heart failure?

<p>Chest congestion (C)</p> Signup and view all the answers

Which agent results in an increase in the force of contraction by increasing calcium levels?

<p>Agents that increase calcium concentration (B)</p> Signup and view all the answers

What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

<p>β-Adrenergic agonist (B)</p> Signup and view all the answers

What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

<p>Hyperkalemia (A)</p> Signup and view all the answers

Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

<p>Loop diuretics (D)</p> Signup and view all the answers

Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

<p>ACE inhibitor (C)</p> Signup and view all the answers

What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

<p>Hypokalemia (A)</p> Signup and view all the answers

Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

<p>Potassium-sparing diuretics (B)</p> Signup and view all the answers

Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

<p>Nitroglycerin (C)</p> Signup and view all the answers

What are the major causes of congestive heart failure (CHF)?

<p>Chronic hypertension, valvular disease, and coronary artery disease (C)</p> Signup and view all the answers

Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

<p>ACE inhibitors (D)</p> Signup and view all the answers

What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

<p>Hypokalemia (D)</p> Signup and view all the answers

Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

<p>Nitroglycerin (C)</p> Signup and view all the answers

What is the main symptom of Class III (moderate) heart failure?

<p>Chest congestion and edema (D)</p> Signup and view all the answers

Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

<p>Bumetanide (D)</p> Signup and view all the answers

Which agent results in an increase in the force of contraction by increasing calcium levels?

<p>Positive inotropic agents (C)</p> Signup and view all the answers

What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

<p>Aldosterone antagonists (A)</p> Signup and view all the answers

Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

<p>Cimetidine (C)</p> Signup and view all the answers

Which class of heart failure is characterized by symptoms occurring at rest?

<p>Class 3 (A)</p> Signup and view all the answers

Which of the following is a potential adverse effect of Angiotensin converting enzyme (ACE) inhibitors therapy in CHF?

<p>Postural hypotension (D)</p> Signup and view all the answers

Which diuretic is commonly used to relieve pulmonary congestion and peripheral edema in CHF?

<p>Hydrochlorothiazide (D)</p> Signup and view all the answers

What is the primary mechanism of action of β-Adrenergic agonists in improving cardiac performance in CHF?

<p>Positive inotropic effects and vasodilation (B)</p> Signup and view all the answers

Which electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

<p>Hypokalemia (A)</p> Signup and view all the answers

Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

<p>Angiotensin II antagonists (D)</p> Signup and view all the answers

What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

<p>Hyperkalemia (A)</p> Signup and view all the answers

Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

<p>Verapamil (D)</p> Signup and view all the answers

What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

<p>Digoxin therapy (A)</p> Signup and view all the answers

Which class of heart failure is characterized by symptoms occurring at rest?

<p>Class IV (severe) (B)</p> Signup and view all the answers

What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

<p>Hypokalemia (C)</p> Signup and view all the answers

Flashcards

What is the source of free intracellular calcium in CHF due to increased sympathetic activity?

The release of calcium from the sarcoplasmic reticulum and mitochondria is a primary source of free intracellular calcium in CHF due to increased sympathetic activity.

What is the most common adverse effect of ACE inhibitor therapy in CHF?

Persistent dry cough is the most common adverse effect associated with ACE inhibitor therapy in CHF.

Which diuretic helps relieve pulmonary congestion and peripheral edema in CHF?

Furosemide is a loop diuretic indicated for relieving pulmonary congestion and peripheral edema in CHF.

What is the direct smooth muscle relaxant used in CHF?

Hydralazine is a direct smooth muscle relaxant used in the treatment of CHF.

Signup and view all the flashcards

What are the pharmacological effects of Angiotensin II blockers?

Angiotensin II blockers dilate venous blood vessels and reduce systemic arteriolar resistance.

Signup and view all the flashcards

How do cardiac glycosides work in CHF?

Cardiac glycosides, like Digoxin, regulate cytosolic calcium concentration and increase cardiac muscle contractility.

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What is the main adverse effect of Angiotensin II antagonist therapy?

Hyperkalemia is the main adverse effect associated with Angiotensin II antagonist therapy in CHF.

Signup and view all the flashcards

Which drug can increase digoxin levels?

Verapamil can increase digoxin levels by 50 to 75%, potentially requiring a digoxin dose reduction.

Signup and view all the flashcards

How do Phosphodiesterase inhibitors work?

Phosphodiesterase inhibitors increase intracellular cAMP, activating protein kinase and increasing calcium entry.

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What electrolyte disturbance can lead to digitalis toxicity?

Hypokalemia can predispose to digitalis toxicity and be prevented by potassium-sparing diuretics or potassium chloride supplementation.

Signup and view all the flashcards

What β-Adrenergic agonist is commonly used for CHF?

Dobutamine is the most commonly used β-Adrenergic agonist for improving cardiac performance in CHF, besides digitalis.

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What therapy is indicated for severe left ventricular systolic dysfunction?

After diuretic and vasodilation therapy, Digoxin therapy along with ACE inhibitors and diuretics is indicated for severe left ventricular systolic dysfunction.

Signup and view all the flashcards

What are the major causes of CHF?

Chronic hypertension, valvular disease, and coronary artery disease are major causes of congestive heart failure (CHF).

Signup and view all the flashcards

What characterizes Class IV heart failure?

Class IV heart failure is characterized by symptoms occurring at rest.

Signup and view all the flashcards

What is the main symptom of Class III heart failure?

The main symptom of Class III (moderate) heart failure is chest congestion.

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How do agents that increase calcium concentration affect heart contraction?

Agents that increase calcium concentration, such as positive inotropes, result in an increase in the force of contraction by increasing calcium levels.

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What is indicated for patients with severe left ventricular systolic dysfunction?

β-Adrenergic agonists are indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy.

Signup and view all the flashcards

What is the main adverse effect of Angiotensin II antagonist therapy?

Hyperkalemia is the main adverse effect associated with Angiotensin II antagonist therapy in CHF.

Signup and view all the flashcards

Which diuretics are effective for pulmonary congestion and peripheral edema in CHF?

Loop diuretics, such as furosemide, are indicated for relieving pulmonary congestion and peripheral edema in CHF.

Signup and view all the flashcards

What are the pharmacological effects of ACE inhibitors?

ACE inhibitors dilate venous blood vessels and reduce systemic arteriolar resistance.

Signup and view all the flashcards

What electrolyte disturbance can lead to digitalis toxicity?

Hypokalemia, low potassium levels, can predispose to digitalis toxicity and be prevented by potassium-sparing diuretics or potassium chloride supplements.

Signup and view all the flashcards

Which drugs can increase digoxin levels?

Potassium-sparing diuretics can increase digoxin levels by 50 to 75%, potentially requiring a digoxin dose reduction.

Signup and view all the flashcards

What is the direct smooth muscle relaxant used in CHF?

Nitroglycerin is a direct smooth muscle relaxant used in the treatment of CHF.

Signup and view all the flashcards

What are the major causes of CHF?

Chronic hypertension, valvular disease, and coronary artery disease are major causes of congestive heart failure (CHF).

Signup and view all the flashcards

What are the pharmacological effects of ACE inhibitors?

ACE inhibitors dilate venous blood vessels and reduce systemic arteriolar resistance.

Signup and view all the flashcards

What electrolyte disturbance can lead to digitalis toxicity?

Hypokalemia, low potassium levels, can predispose to digitalis toxicity and be prevented by potassium-sparing diuretics or potassium chloride supplements.

Signup and view all the flashcards

What is the direct smooth muscle relaxant used in CHF?

Nitroglycerin is a direct smooth muscle relaxant used in the treatment of CHF.

Signup and view all the flashcards

What is the main symptom of Class III (moderate) heart failure?

The main symptom of Class III (moderate) heart failure is chest congestion and edema.

Signup and view all the flashcards

Which diuretic is used for pulmonary congestion and peripheral edema in CHF?

Bumetanide is a loop diuretic indicated for relieving pulmonary congestion and peripheral edema in CHF.

Signup and view all the flashcards

How do positive inotropic agents affect heart contraction?

Positive inotropic agents increase the force of contraction by increasing calcium levels within the heart.

Signup and view all the flashcards

What is indicated for severe left ventricular systolic dysfunction?

Aldosterone antagonists are indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy.

Signup and view all the flashcards

Which drug can increase digoxin levels?

Cimetidine can increase digoxin levels by 50 to 75%, potentially requiring a digoxin dose reduction.

Signup and view all the flashcards

What characterizes Class 3 heart failure?

Class 3 heart failure is characterized by symptoms occurring at rest.

Signup and view all the flashcards

What is a potential adverse effect of ACE inhibitors therapy in CHF?

Postural hypotension is a potential adverse effect of Angiotensin converting enzyme (ACE) inhibitors therapy in CHF.

Signup and view all the flashcards

Which diuretic is commonly used for pulmonary congestion and peripheral edema in CHF?

Hydrochlorothiazide is a thiazide diuretic commonly used to relieve pulmonary congestion and peripheral edema in CHF.

Signup and view all the flashcards

What is the primary mechanism of action of β-Adrenergic agonists in CHF?

The primary mechanism of action of β-Adrenergic agonists in improving cardiac performance in CHF is their positive inotropic effects and vasodilation.

Signup and view all the flashcards

What electrolyte disturbance can lead to digitalis toxicity?

Hypokalemia, low potassium levels, can predispose to digitalis toxicity and be prevented by potassium-sparing diuretics or potassium chloride supplements.

Signup and view all the flashcards

What are the pharmacological effects of Angiotensin II antagonists?

Angiotensin II antagonists dilate venous blood vessels and reduce systemic arteriolar resistance.

Signup and view all the flashcards

What is the main adverse effect of Angiotensin II antagonist therapy in CHF?

Hyperkalemia is the main adverse effect associated with Angiotensin II antagonist therapy in CHF.

Signup and view all the flashcards

Which drug can increase digoxin levels?

Verapamil can increase digoxin levels by 50 to 75%, potentially requiring a digoxin dose reduction.

Signup and view all the flashcards

What therapy is indicated for severe left ventricular systolic dysfunction?

Digoxin therapy is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy.

Signup and view all the flashcards

What characterizes Class IV (severe) heart failure?

Class IV (severe) heart failure is characterized by symptoms occurring at rest.

Signup and view all the flashcards

What electrolyte disturbance can lead to digitalis toxicity?

Hypokalemia, low potassium levels, can predispose to digitalis toxicity and be prevented by potassium-sparing diuretics or potassium chloride supplements.

Signup and view all the flashcards

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