Congestive Heart Failure (CHF) Learning
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Questions and Answers

Which of the following is a source of free intracellular calcium in CHF due to increased sympathetic activity?

  • Decrease in cardiac preload
  • Release of calcium from the sarcoplasmic reticulum and mitochondria (correct)
  • Reduction in systemic arteriolar resistance
  • Dilation of venous blood vessels
  • Which adverse effect is most commonly associated with ACE inhibitor therapy in CHF?

  • Persistent dry cough (correct)
  • Renal insufficiency
  • Postural hypotension
  • Hyperkalemia
  • Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

  • Metolazone
  • Hydrochlorothiazide
  • Furosemide (correct)
  • Bumetanide
  • Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

    <p>(hydralazine)</p> Signup and view all the answers

    Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

    <p>Angiotensin II blockers</p> Signup and view all the answers

    Which drug's mechanism of action involves regulation of cytosolic calcium concentration and increased contractility of cardiac muscle?

    <p>Cardiac glycosides (Digitalis)</p> Signup and view all the answers

    What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

    <p>Hyperkalemia</p> Signup and view all the answers

    Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

    <p>Verapamil</p> Signup and view all the answers

    Which inotropic agent leads to an increase in intracellular cAMP, resulting in the activation of protein kinase, phosphorylation of calcium channel, and increased calcium entrance?

    <p>Phosphodiesterase inhibitors</p> Signup and view all the answers

    What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

    <p>Hypokalemia</p> Signup and view all the answers

    What is the most commonly used β-Adrenergic agonist other than digitalis for improving cardiac performance in CHF?

    <p>Dobutamine</p> Signup and view all the answers

    What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

    <p>Digoxin therapy along with ACE inhibitors and diuretics</p> Signup and view all the answers

    What are the major causes of congestive heart failure (CHF)?

    <p>Chronic hypertension, valvular disease, and coronary artery disease</p> Signup and view all the answers

    Which class of heart failure is characterized by symptoms occurring at rest?

    <p>Class IV (severe)</p> Signup and view all the answers

    What is the main symptom of Class III (moderate) heart failure?

    <p>Chest congestion</p> Signup and view all the answers

    Which agent results in an increase in the force of contraction by increasing calcium levels?

    <p>Agents that increase calcium concentration</p> Signup and view all the answers

    What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

    <p>β-Adrenergic agonist</p> Signup and view all the answers

    What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

    <p>Hyperkalemia</p> Signup and view all the answers

    Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

    <p>Loop diuretics</p> Signup and view all the answers

    Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

    <p>ACE inhibitor</p> Signup and view all the answers

    What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

    <p>Hypokalemia</p> Signup and view all the answers

    Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

    <p>Potassium-sparing diuretics</p> Signup and view all the answers

    Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

    <p>Nitroglycerin</p> Signup and view all the answers

    What are the major causes of congestive heart failure (CHF)?

    <p>Chronic hypertension, valvular disease, and coronary artery disease</p> Signup and view all the answers

    Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

    <p>ACE inhibitors</p> Signup and view all the answers

    What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

    <p>Hypokalemia</p> Signup and view all the answers

    Which drug is a direct smooth muscle relaxant used in the treatment of CHF?

    <p>Nitroglycerin</p> Signup and view all the answers

    What is the main symptom of Class III (moderate) heart failure?

    <p>Chest congestion and edema</p> Signup and view all the answers

    Which diuretic is indicated for relieving pulmonary congestion and peripheral edema in CHF?

    <p>Bumetanide</p> Signup and view all the answers

    Which agent results in an increase in the force of contraction by increasing calcium levels?

    <p>Positive inotropic agents</p> Signup and view all the answers

    What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

    <p>Aldosterone antagonists</p> Signup and view all the answers

    Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

    <p>Cimetidine</p> Signup and view all the answers

    Which class of heart failure is characterized by symptoms occurring at rest?

    <p>Class 3</p> Signup and view all the answers

    Which of the following is a potential adverse effect of Angiotensin converting enzyme (ACE) inhibitors therapy in CHF?

    <p>Postural hypotension</p> Signup and view all the answers

    Which diuretic is commonly used to relieve pulmonary congestion and peripheral edema in CHF?

    <p>Hydrochlorothiazide</p> Signup and view all the answers

    What is the primary mechanism of action of β-Adrenergic agonists in improving cardiac performance in CHF?

    <p>Positive inotropic effects and vasodilation</p> Signup and view all the answers

    Which electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

    <p>Hypokalemia</p> Signup and view all the answers

    Which medication's pharmacological effects include dilation of venous blood vessels and reduction of systemic arteriolar resistance?

    <p>Angiotensin II antagonists</p> Signup and view all the answers

    What is the main adverse effect associated with Angiotensin II antagonist therapy in CHF?

    <p>Hyperkalemia</p> Signup and view all the answers

    Which drug can increase digoxin levels by 50 to 75% and may require a reduction in the dose of digoxin?

    <p>Verapamil</p> Signup and view all the answers

    What is indicated for patients with severe left ventricular systolic dysfunction after initiation of diuretic and vasodilation therapy?

    <p>Digoxin therapy</p> Signup and view all the answers

    Which class of heart failure is characterized by symptoms occurring at rest?

    <p>Class IV (severe)</p> Signup and view all the answers

    What electrolytic disturbance can predispose to digitalis toxicity and can be prevented by use of a potassium sparing diuretic or supplementation with potassium chloride?

    <p>Hypokalemia</p> Signup and view all the answers

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