20 Questions
What is a key characteristic of L type voltage gated calcium channels?
They are responsible for the upstroke of the action potential in cardiac myocytes
Which of the following is a physiology characteristic of calcium?
It acts as a secondary messenger in signal transduction pathways
How do DHP and Non-DHP calcium channel blockers (CCBs) differ?
Non-DHP CCBs are more effective in reducing peripheral vascular resistance
In the context of calcium channel blockers (CCBs), which factor is included in the pharmacokinetic profile?
Route of administration
What condition should be considered when deciding to use or avoid calcium channel blockers (CCBs)?
Bronchospastic lung disease
What is a key characteristic of L type voltage gated calcium channels?
They are activated by depolarization
Which factor is NOT typically a pharmacokinetic profile detail of calcium channel blockers (CCBs)?
Cardiac contractility effect
What is a common adverse drug reaction (ADR) associated with calcium channel blockers (CCBs)?
Hyperglycemia
Which of the following conditions is important to consider when deciding to use or avoid calcium channel blockers (CCBs)?
Hypotension
What effect do calcium channel blockers (CCBs) have on coronary blood flow?
Increase coronary blood flow
What is a key characteristic of L type voltage gated calcium channels?
They are primarily found in the heart
Which factor is NOT typically a pharmacokinetic profile detail of calcium channel blockers (CCBs)?
First-pass metabolism
How do dihydropyridine (DHP) and non-dihydropyridine (Non-DHP) calcium channel blockers (CCBs) differ?
Non-DHPs have a greater vasodilatory effect on coronary arteries
What condition should be considered when deciding to use or avoid calcium channel blockers (CCBs)?
Asthma
What effect do calcium channel blockers (CCBs) have on plasma renin?
Decrease plasma renin levels
What is a distinguishing feature of L type voltage-gated calcium channels?
They are activated by depolarization
Which condition should generally be avoided when considering the use of calcium channel blockers (CCBs)?
Severe bradycardia
What effect do calcium channel blockers (CCBs) typically have on cardiac contractility?
Decrease it
In terms of pharmacokinetics, which detail is often associated with dihydropyridine (DHP) calcium channel blockers?
High bioavailability
What is a possible effect of calcium channel blockers (CCBs) on left ventricular hypertrophy?
Reducing hypertrophy
Test your knowledge on L type voltage gated calcium channels, DHP and Non-DHP calcium channel blockers, effects of calcium channel blockers on various physiological parameters, and conditions for using or avoiding CCBs. Identify MOA, ADRs, and pharmacokinetics of CCBs using the top 400 drug list.
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