Calcium Channel Blockers Quiz
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Questions and Answers

What is a key characteristic of L type voltage gated calcium channels?

  • They are activated by hyperpolarization
  • They are permeable to sodium ions
  • They are responsible for the upstroke of the action potential in cardiac myocytes (correct)
  • They are primarily found in skeletal muscle

Which of the following is a physiology characteristic of calcium?

  • It has no role in blood clotting
  • It decreases the release of neurotransmitters at synapses
  • It inhibits muscle contraction
  • It acts as a secondary messenger in signal transduction pathways (correct)

How do DHP and Non-DHP calcium channel blockers (CCBs) differ?

  • DHP CCBs primarily target cardiac calcium channels
  • DHP CCBs have a stronger effect on smooth muscle cells
  • Non-DHP CCBs are more effective in reducing peripheral vascular resistance (correct)
  • Non-DHP CCBs are contraindicated in hypertension

In the context of calcium channel blockers (CCBs), which factor is included in the pharmacokinetic profile?

<p>Route of administration (D)</p> Signup and view all the answers

What condition should be considered when deciding to use or avoid calcium channel blockers (CCBs)?

<p>Bronchospastic lung disease (D)</p> Signup and view all the answers

What is a key characteristic of L type voltage gated calcium channels?

<p>They are activated by depolarization (A)</p> Signup and view all the answers

Which factor is NOT typically a pharmacokinetic profile detail of calcium channel blockers (CCBs)?

<p>Cardiac contractility effect (C)</p> Signup and view all the answers

What is a common adverse drug reaction (ADR) associated with calcium channel blockers (CCBs)?

<p>Hyperglycemia (D)</p> Signup and view all the answers

Which of the following conditions is important to consider when deciding to use or avoid calcium channel blockers (CCBs)?

<p>Hypotension (B)</p> Signup and view all the answers

What effect do calcium channel blockers (CCBs) have on coronary blood flow?

<p>Increase coronary blood flow (D)</p> Signup and view all the answers

What is a key characteristic of L type voltage gated calcium channels?

<p>They are primarily found in the heart (B)</p> Signup and view all the answers

Which factor is NOT typically a pharmacokinetic profile detail of calcium channel blockers (CCBs)?

<p>First-pass metabolism (D)</p> Signup and view all the answers

How do dihydropyridine (DHP) and non-dihydropyridine (Non-DHP) calcium channel blockers (CCBs) differ?

<p>Non-DHPs have a greater vasodilatory effect on coronary arteries (A)</p> Signup and view all the answers

What condition should be considered when deciding to use or avoid calcium channel blockers (CCBs)?

<p>Asthma (D)</p> Signup and view all the answers

What effect do calcium channel blockers (CCBs) have on plasma renin?

<p>Decrease plasma renin levels (A)</p> Signup and view all the answers

What is a distinguishing feature of L type voltage-gated calcium channels?

<p>They are activated by depolarization (A)</p> Signup and view all the answers

Which condition should generally be avoided when considering the use of calcium channel blockers (CCBs)?

<p>Severe bradycardia (A)</p> Signup and view all the answers

What effect do calcium channel blockers (CCBs) typically have on cardiac contractility?

<p>Decrease it (D)</p> Signup and view all the answers

In terms of pharmacokinetics, which detail is often associated with dihydropyridine (DHP) calcium channel blockers?

<p>High bioavailability (D)</p> Signup and view all the answers

What is a possible effect of calcium channel blockers (CCBs) on left ventricular hypertrophy?

<p>Reducing hypertrophy (B)</p> Signup and view all the answers

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