Congenital Adrenal Hyperplasia and Adrenal Insufficiency Symptoms

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Questions and Answers

What is the primary diagnostic marker for congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency?

  • DHEA
  • 17-hydroxyprogesterone (correct)
  • 11-deoxycortisol
  • Cortisol

Which enzyme deficiency is associated with elevated 11-deoxycortisol levels?

  • 11β-hydroxylase deficiency (correct)
  • 17α-hydroxylase deficiency
  • 21-hydroxylase deficiency
  • 3β-hydroxysteroid dehydrogenase deficiency

Which of the following is NOT a characteristic of catecholamines?

  • Produced from phenylalanine
  • Synthesized in the adrenal medulla
  • Increase blood glucose levels
  • Act as neurotransmitters (correct)

Which of the following is the most important substance produced by the adrenal medulla?

<p>Epinephrine (A)</p> Signup and view all the answers

What is the primary function of epinephrine (adrenaline)?

<p>Mobilizing energy stores by converting glycogen to glucose (C)</p> Signup and view all the answers

Which type of adrenal insufficiency is characterized by low cortisol, low aldosterone, and high androgenic hormones?

<p>Congenital adrenal hyperplasia (B)</p> Signup and view all the answers

Which of the following is a clinical manifestation of androgen excess in infant girls?

<p>Ambiguous genitalia (A)</p> Signup and view all the answers

Which of the following is a diagnostic marker for congenital adrenal hyperplasia (CAH)?

<p>Elevated plasma DHEAS and DHEA levels (D)</p> Signup and view all the answers

Which of the following is a potential cause of adrenal insufficiency?

<p>Addison's disease (A)</p> Signup and view all the answers

In men, excess androgens converted to estrogens can lead to which of the following effects?

<p>Infertility with feminizing effects (A)</p> Signup and view all the answers

Which of the following statements is true regarding DHEA and DHEAS?

<p>DHEAS has a tighter binding to albumin compared to DHEA (D)</p> Signup and view all the answers

Which of the following is a symptom of glucocorticoid deficiency in adrenal insufficiency?

<p>Hypoglycemia (B)</p> Signup and view all the answers

What is the most common cause of adrenal insufficiency mentioned in the text?

<p>Infection (tuberculosis) (B)</p> Signup and view all the answers

In congenital adrenal hyperplasia (CAH), the levels of DHEA/DHEAS are often elevated by how much?

<p>5-fold to 10-fold (D)</p> Signup and view all the answers

Which of the following best describes congenital adrenal hyperplasia (CAH)?

<p>A group of autosomal recessive disorders disrupting cortisol production due to enzyme deficiency (C)</p> Signup and view all the answers

Which type of adrenal insufficiency occurs when the hypothalamus fails to produce sufficient amounts of CRH?

<p>Tertiary adrenal insufficiency (A)</p> Signup and view all the answers

Which of the following symptoms is associated with mineralocorticoid deficiency in adrenal insufficiency?

<p>Hypercalcemia (B)</p> Signup and view all the answers

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