Congenital & Acquired Bone Disorders Overview Quiz

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What is the primary age group in which Osteitis Deformans commonly begins?

Late adulthood

In which regions is Paget Disease of the Bone more commonly prevalent?

England and USA

What is the predominant bone involvement in Paget Disease of the Bone?

Axial skeleton or proximal femur

What is the main reason for pain experienced by individuals with Paget Disease of the Bone?

<p>Microfractures</p> Signup and view all the answers

What is a potential long-term complication associated with Paget Disease of the Bone?

<p>Osteosarcoma</p> Signup and view all the answers

Which bone disorder is characterized by decreased bone mass but not severe enough to significantly increase the risk of fracture?

<p>Osteopenia</p> Signup and view all the answers

In advanced osteoporosis, which bone component is markedly thinned?

<p>Trabecular bone of the medulla</p> Signup and view all the answers

What is the most common skeletal dysplasia that is a major cause of dwarfism?

<p>Achondroplasia</p> Signup and view all the answers

Which condition can cause significant loss of height and deformities like lumbar lordosis and kyphoscoliosis?

<p>Vertebral fractures</p> Signup and view all the answers

Which gene mutation is responsible for Achondroplasia, the most common skeletal dysplasia?

<p>Mutations in fibroblast growth factor receptor 3 (FGFR3)</p> Signup and view all the answers

What is the best screening method for diagnosing osteoporosis?

<p>Dual-energy x-ray absorptiometry (DEXA scan)</p> Signup and view all the answers

Which type of Osteogenesis imperfecta variant is fatal either in utero or during the perinatal period?

<p>Type 2 variant</p> Signup and view all the answers

Which condition results in increased osteoclast activity, bone resorption, osteopenia, and osteoporosis?

<p>Hyperparathyroidism</p> Signup and view all the answers

What is the average yearly loss of bone mass in postmenopausal women with osteoporosis?

<p>0.7% of cortical bone and 2% of medullary bone</p> Signup and view all the answers

What is the manifestation of vitamin D deficiency that interferes with bone deposition in growth plates?

<p>Rickets</p> Signup and view all the answers

Which disorder involves extreme skeletal fragility due to mutations in genes encoding type I collagen chains?

<p>Osteogenesis imperfecta</p> Signup and view all the answers

Which condition presents with cystic degeneration of brown tumors with increased fibrosis?

<p>Paget disease of the bone</p> Signup and view all the answers

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