Common Cutaneous Diseases

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Questions and Answers

A patient presents with a chronic nail infection characterized by thickening, discoloration, and brittleness. Which etiological agent and treatment strategy would be most appropriate?

  • Epidermophyton floccosum, treated effectively with topical clotrimazole alone.
  • Microsporum audouinii, best managed with short-term itraconazole applications.
  • Trichophyton rubrum, requiring a prolonged course of oral terbinafine. (correct)
  • Trichophyton mentagrophytes, typically resolving spontaneously with improved hygiene.

A dermatologist examines a patient with circular, scaly lesions on the trunk exhibiting central clearing and an inflamed periphery. Which diagnostic and management steps are most appropriate for this condition?

  • Obtain a skin scraping for microscopic examination and initiate oral griseofulvin therapy. (correct)
  • Recommend keeping the area dry and exposed to sunlight to inhibit fungal growth.
  • Advise on the use of topical corticosteroids to reduce inflammation and itching.
  • Prescribe a broad-spectrum antibiotic to address potential bacterial involvement.

Healthcare workers should be particularly diligent about implementing which of the following infection control measures to prevent the transmission of cutaneous mycoses?

  • Routine vaccination against common dermatophytes for high-risk populations.
  • Isolating patients with fungal infections in negative pressure rooms.
  • Ensuring thorough disinfection of shared equipment and surfaces. (correct)
  • Administering prophylactic antibiotics to all patients with skin conditions.

How does the unique metabolic capability of dermatophytes contribute to their pathogenic mechanism in cutaneous infections?

<p>Dermatophytes secrete enzymes that degrade keratin, facilitating invasion and colonization of skin, hair, and nails. (A)</p> Signup and view all the answers

A patient is diagnosed with Tinea capitis due to Microsporum infection. What clinical findings would be most indicative of this specific etiology?

<p>Green fluorescence of infected hair shafts under Wood's lamp examination. (B)</p> Signup and view all the answers

Which of the following factors would be MOST significant in predisposing an individual to the development of Tinea cruris?

<p>Wearing tight-fitting, non-breathable clothing, leading to increased moisture and friction in the groin area. (C)</p> Signup and view all the answers

Following diagnosis of Tinea pedis, a patient is prescribed topical antifungal medication. What additional advice should the healthcare provider offer to enhance treatment efficacy and prevent recurrence?

<p>Keep feet dry and well-ventilated, using antifungal powder in shoes and socks. (A)</p> Signup and view all the answers

What key difference distinguishes dermatophytes from other types of fungi that cause systemic mycoses?

<p>Dermatophytes are limited to superficial infections of skin, hair, and nails due to their reliance on keratin for nutrition, unlike systemic fungi that can invade deeper tissues. (D)</p> Signup and view all the answers

What is the MOST critical factor in determining the appropriate duration of treatment for onychomycosis?

<p>The extent of nail involvement and the rate of nail growth, as treatment must continue until all infected portions of the nail have been replaced by healthy tissue. (B)</p> Signup and view all the answers

A patient with Tinea capitis is treated with oral griseofulvin but shows no improvement after several weeks. How should the treatment strategy be adapted?

<p>Switch to a different oral antifungal agent, such as terbinafine or itraconazole. (C)</p> Signup and view all the answers

Flashcards

Dermatophytes

Fungi that infect keratinized tissues (skin, hair, nails).

Tinea Pedis

Fungal infection, often between toes, caused by Trichophyton species.

Tinea Corporis

Ring-shaped fungal lesions caused by Epidermophyton, Trichophyton, or Microsporum.

Tinea Capitis

Scalp infection by Trichophyton or Microsporum, causing scaling and hair loss.

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Tinea Cruris

Groin infection caused by Epidermophyton floccosum or Trichophyton rubrum.

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Tinea Unguium (Onychomycosis)

Nail infection, often by Trichophyton rubrum, causing thickened, discolored nails.

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Treatment for Dermatophytosis

Removal of infected tissue and topical/oral antifungals.

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Dermatophytes Characteristic

Ability to use keratin as a nutrient source.

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Study Notes

  • Common cutaneous diseases arise from related fungi known as dermatophytes.
  • Dermatophytes infect keratinized tissues, including skin, hair, and nails, causing superficial infections.
  • The three genera of dermatophytes are Trichophyton, Epidermophyton, and Microsporum, each consisting of many species.

Tinea Pedis (Athlete's Foot)

  • Commonly isolated fungi include Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
  • Initially, infection occurs between the toes, potentially spreading to the nails and causing them to become yellow and brittle.
  • Skin fissures can lead to secondary bacterial infections, resulting in lymph node inflammation.
  • Moisture from foot sweating promotes fungal growth.

Tinea Corporis (Ringworm)

  • Epidermophyton, Trichophyton, and Microsporum are the most frequently isolated fungi.
  • Lesions manifest as rings that expand with scaly centers.
  • The ring's periphery, which contains active fungal growth, is typically inflamed and vesiculated.
  • Lesions commonly appear on non-hairy areas of the trunk, including the iliac side, though any body site can be affected.

Tinea Capitis (Scalp Ringworm)

  • Several Trichophyton and Microsporum species are isolated from scalp ringworm lesions.
  • In the United States, the predominant infecting species is Trichophyton tonsurans.
  • Disease manifestations range from small scaling patches to extensive hair loss involving the entire scalp.
  • Microsporum hyphae can infect hair shafts, which can be detected by green fluorescence under Wood's lamp (long-wave ultraviolet light).

Tinea Cruris (Jock Itch)

  • Epidermophyton floccosum and Trichophyton rubrum are the causative organisms.
  • Disease manifestations resemble tinea pedis, but lesions occur in moist groin areas.
  • Lesions can spread from the upper thigh to the genitals.

Tinea Unguium (Onychomycosis)

  • Trichophyton rubrum causes tinea unguium.
  • The nails thicken, become discolored, and brittle.
  • Treatment must continue for three to four months until all infected portions of the nail have grown out and are trimmed off.

Treatment

  • Initial treatment involves removing infected skin, followed by topical application of antifungal drugs like itraconazole and clotrimazole.
  • Refractory or resistant infections typically respond well to oral treatments like terbinafine and griseofulvin.
  • Terbinafine is the preferred drug for onychomycosis.

Transmission & Characteristics

  • Cutaneous mycoses are transmitted from human to human or animal to human via infected skin scales on inanimate objects.
  • Dermatophytes can utilize keratin as a source of nutrition.
  • This ability allows them to invade keratinized tissues and structures such as skin, hair, and nails.
  • They do not invade underlying non-keratinized tissue.
  • Dermatophytes cause itching, scaly skin patches that can become inflamed and vesicular/weeping.
  • Specific diseases are usually identified according to the affected tissue, such as the scalp, pubic area, or feet.

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