18 Questions
What is the function of proteoglycans in the Extra-Cellular Matrix (ECM)?
Confer lubrication and hydration
Which component of the ECM is a major constituent of the basement membrane?
Laminin
What is critical to the development of strength in a healing wound site?
Collagen synthesis
What is the main role of an intact ECM in tissue regeneration?
Facilitate tissue regeneration
What family of enzymes is responsible for the degradation of collagens and other ECM components?
Matrix metalloproteinases (MMPs)
When does repair by connective tissue occur?
After tissue injury becomes severe or chronic
What is characteristic of granulation tissue during healing?
Granular gross appearance
Which type of collagenases cleave fibrillar collagen like type 1, 2, and 3?
Interstitial collagenases
What process should be controlled for the proper remodeling of connective tissue?
Remodeling of Connective Tissue
Which molecule is stored in the basement membrane for quick involvement in healing after local injury?
FGF (fibroblast growth factor)
Healing by second intention involves:
Accumulation of ECM
What type of wound healing involves cell or tissue loss that is more extensive?
Healing by second intention
What process is characterized by the proliferation of fibroblasts and new delicate capillaries?
Angiogenesis
Which factor is responsible for the migration and proliferation of fibroblasts?
PDGF
What is the result of the deposition of extracellular matrix (ECM) by fibroblasts?
Scar formation
Which process allows tumors to grow beyond their original blood supply?
Angiogenesis
What factors are responsible for the migration of endothelial cells during tissue repair?
VEGF, TGF-β, and PDGF
Which factor suppresses the proliferation and migration of endothelial cells during repair processes?
TGF-β
Test your knowledge on collagen synthesis, ECM degradation, and the repair process of connective tissue. Learn about the importance of collagen in wound healing, excess collagen deposition in keloid scars, and the role of matrix metalloproteinases in ECM degradation.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
