Collagen Synthesis and Connective Tissue Repair Quiz
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Questions and Answers

What is the function of proteoglycans in the Extra-Cellular Matrix (ECM)?

  • Confer lubrication and hydration (correct)
  • Serve as reservoirs for growth factors
  • Regulate cell proliferation
  • Provide mechanical support to tissues
  • Which component of the ECM is a major constituent of the basement membrane?

  • Laminin (correct)
  • Elastin
  • Collagens
  • Fibronectin
  • What is critical to the development of strength in a healing wound site?

  • Macrophage response
  • Collagen synthesis (correct)
  • ECM degradation
  • Fibroblast activity
  • What is the main role of an intact ECM in tissue regeneration?

    <p>Facilitate tissue regeneration</p> Signup and view all the answers

    What family of enzymes is responsible for the degradation of collagens and other ECM components?

    <p>Matrix metalloproteinases (MMPs)</p> Signup and view all the answers

    When does repair by connective tissue occur?

    <p>After tissue injury becomes severe or chronic</p> Signup and view all the answers

    What is characteristic of granulation tissue during healing?

    <p>Granular gross appearance</p> Signup and view all the answers

    Which type of collagenases cleave fibrillar collagen like type 1, 2, and 3?

    <p>Interstitial collagenases</p> Signup and view all the answers

    What process should be controlled for the proper remodeling of connective tissue?

    <p>Remodeling of Connective Tissue</p> Signup and view all the answers

    Which molecule is stored in the basement membrane for quick involvement in healing after local injury?

    <p>FGF (fibroblast growth factor)</p> Signup and view all the answers

    Healing by second intention involves:

    <p>Accumulation of ECM</p> Signup and view all the answers

    What type of wound healing involves cell or tissue loss that is more extensive?

    <p>Healing by second intention</p> Signup and view all the answers

    What process is characterized by the proliferation of fibroblasts and new delicate capillaries?

    <p>Angiogenesis</p> Signup and view all the answers

    Which factor is responsible for the migration and proliferation of fibroblasts?

    <p>PDGF</p> Signup and view all the answers

    What is the result of the deposition of extracellular matrix (ECM) by fibroblasts?

    <p>Scar formation</p> Signup and view all the answers

    Which process allows tumors to grow beyond their original blood supply?

    <p>Angiogenesis</p> Signup and view all the answers

    What factors are responsible for the migration of endothelial cells during tissue repair?

    <p>VEGF, TGF-β, and PDGF</p> Signup and view all the answers

    Which factor suppresses the proliferation and migration of endothelial cells during repair processes?

    <p>TGF-β</p> Signup and view all the answers

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